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Original Article

Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci

  1. Patrick Holton1,
  2. Mina Ryten1,
  3. Michael Nalls2,
  4. Daniah Trabzuni1,3,
  5. Michael E. Weale4,
  6. Dena Hernandez1,2,
  7. Helen Crehan1,
  8. J. Raphael Gibbs1,2,
  9. Richard Mayeux5,
  10. Jonathan L. Haines6,
  11. Lindsay A. Farrer7,
  12. Margaret A. Pericak-Vance8,
  13. Gerard D. Schellenberg9,
  14. The Alzheimer's Disease Genetics Consortium†,
  15. Manuel Ramirez-Restrepo10,11,
  16. Anzhelika Engel10,11,
  17. Amanda J. Myers10,11,
  18. Jason J. Corneveaux12,
  19. Matthew J. Huentelman12,
  20. Allissa Dillman2,13,
  21. Mark R. Cookson2,
  22. Eric M. Reiman12,14,15,
  23. Andrew Singleton2,
  24. John Hardy1,16,*,
  25. Rita Guerreiro1

Article first published online: 30 JAN 2013

DOI: 10.1111/ahg.12000

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 77, Issue 2, pages 85–105, March 2013

Additional Information

How to Cite

Holton, P., Ryten, M., Nalls, M., Trabzuni, D., Weale, M. E., Hernandez, D., Crehan, H., Gibbs, J. R., Mayeux, R., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Schellenberg, G. D., The Alzheimer's Disease Genetics Consortium, Ramirez-Restrepo, M., Engel, A., Myers, A. J., Corneveaux, J. J., Huentelman, M. J., Dillman, A., Cookson, M. R., Reiman, E. M., Singleton, A., Hardy, J. and Guerreiro, R. (2013), Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci. Annals of Human Genetics, 77: 85–105. doi: 10.1111/ahg.12000

Author Information

  1. 1

    Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

  2. 2

    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD

  3. 3

    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

  4. 4

    Department of Medical & Molecular Genetics, King's College London, Guy's Hospital, London, UK

  5. 5

    Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY

  6. 6

    Department of Molecular Physiology and Biophysics and Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN

  7. 7

    Departments of Medicine (Biomedical Genetics), Biostatistics, Ophthalmology, Epidemiology, and Neurology, Boston University Schools of Medicine and Public Health, Boston, MA

  8. 8

    The John P. Hussman Institute for Human Genomics and Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL

  9. 9

    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

  10. 10

    Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL

  11. 11

    Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute, Tampa, FL

  12. 12

    Neurogenomics Division, Translational Genomics Research Institute and Arizona Alzheimer's Consortium, Phoenix, AZ

  13. 13

    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

  14. 14

    Banner Alzheimer's Institute and Department of Psychiatry, University of Arizona, Phoenix, AZ

  15. 15

    Department of Psychiatry, University of Arizona, Tucson, AZ

  16. 16

    Reta Lila Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

  1. †

    Coauthors from the Alzheimer's Disease Genetics Consortium are listed at the end of the manuscript.

*Corresponding author: JOHN HARDY, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. Tel: +44 207 829 8722; Fax: +44 207 833 1016; E-mail: j.hardy@ion.ucl.ac.uk

  1. †

    Coauthors from the Alzheimer's Disease Genetics Consortium are listed at the end of the manuscript.

Publication History

  1. Issue published online: 19 FEB 2013
  2. Article first published online: 30 JAN 2013
  3. Manuscript Accepted: 5 MAR 2012
  4. Manuscript Received: 19 JAN 2012

Funded by

  • National Institute of Health, National Institute on Aging. Grant Number: Z01-AG000950-10
  • The National Institute on Aging. Grant Numbers: R01 AG034504, R01 AG031581, P30 AG19610, Z01 AG000950-06, P30AG10161, R01AG15819
  • The National Institute of Neurological Disorders and Stroke. Grant Number: R01NS059873
  • NACC. Grant Number: #U01 AG016976
  • NIH. Grant Number: P50-AG08671
  • ADGC. Grant Numbers: U01 AG032984, RC2 AG036528
  • NACC. Grant Number: U01 AG016976
  • NCRAD. Grant Number: U24 AG021886
  • NIA LOAD. Grant Numbers: U24 AG026395, U24 AG026390
  • Banner Sun Health Research Institute. Grant Number: P30 AG019610
  • Boston University. Grant Numbers: P30 AG013846, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG017173, R01 AG025259, R01AG33193
  • Columbia University. Grant Numbers: P50 AG008702, R37 AG015473
  • Duke University. Grant Numbers: P30 AG028377, AG05128
  • Emory University. Grant Number: AG025688
  • Group Health Research Institute. Grant Numbers: UO1 AG06781, UO1 HG004610
  • Indiana University. Grant Number: P30 AG10133
  • Johns Hopkins University. Grant Numbers: P50 AG005146, R01 AG020688
  • Massachusetts General Hospital. Grant Number: P50 AG005134
  • Mayo Clinic. Grant Number: P50 AG016574
  • Mount Sinai School of Medicine. Grant Numbers: P50 AG005138, P01 AG002219
  • New York University. Grant Numbers: P30 AG08051, MO1RR00096, UL1 RR029893
  • Northwestern University. Grant Number: P30 AG013854
  • Oregon Health & Science University. Grant Numbers: P30 AG008017, R01 AG026916
  • Rush University. Grant Numbers: P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, R01 AG30146
  • TGen. Grant Number: R01 NS059873
  • University of Alabama at Birmingham. Grant Numbers: P50 AG016582, UL1RR02777
  • University of Arizona. Grant Number: R01 AG031581
  • University of California, Davis. Grant Number: P30 AG010129
  • University of California, Irvine. Grant Numbers: P50 AG016573, P50, P50 AG016575, P50 AG016576, P50 AG016577
  • University of California, Los Angeles. Grant Number: P50 AG016570
  • University of California, San Diego. Grant Number: P50 AG005131
  • University of California, San Francisco. Grant Numbers: P50 AG023501, P01 AG019724
  • University of Kentucky. Grant Numbers: P30 AG028383, AG05144
  • University of Michigan. Grant Number: P50 AG008671
  • University of Pennsylvania. Grant Number: P30 AG010124
  • University of Pittsburgh. Grant Numbers: P50 AG005133, AG030653
  • University of Southern California. Grant Number: P50 AG005142
  • University of Texas Southwestern. Grant Number: P30 AG012300
  • University of Miami. Grant Numbers: R01 AG027944, AG010491, AG027944, AG021547, AG019757
  • University of Washington. Grant Number: P50 AG005136
  • Vanderbilt University. Grant Number: R01 AG019085
  • Washington University. Grant Numbers: P50 AG005681, P01 AG03991
  • NINDS. Grant Number: NS39764
  • NIMH. Grant Number: MH60451
  • LAF. Grant Numbers: IIRG-08–89720, MP-V, IIRG-05–14147
  • NIA. Grant Numbers: U01 AG024904, RC2 AG036535, K01 AG030514

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