Original Article

Analysis of Family- and Population-Based Samples Using Multiple Linkage Disequilibrium Mapping

  1. Yen-Feng Chiu1,*,
  2. Chun-Yi Lee1,
  3. Hui-Yi Kao1,
  4. Wen-Harn Pan2,
  5. Fang-Chi Hsu3

Article first published online: 18 JAN 2013

DOI: 10.1111/ahg.12008

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 77, Issue 3, pages 251–267, May 2013

Additional Information

How to Cite

Chiu, Y.-F., Lee, C.-Y., Kao, H.-Y., Pan, W.-H. and Hsu, F.-C. (2013), Analysis of Family- and Population-Based Samples Using Multiple Linkage Disequilibrium Mapping. Annals of Human Genetics, 77: 251–267. doi: 10.1111/ahg.12008

Author Information

  1. 1

    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan, ROC

  2. 2

    Division of Health Services and Preventive Medicine, Institute of Population Health Sciences, National Health Research Institutes, Taiwan, ROC

  3. 3

    Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC

*Corresponding author: Yen-Feng Chiu, 35 Keyan Rd., Zhunan, Miaoli 350, Taiwan, ROC. Tel: +886-37-246-266 ext. 36107; Fax: +886-37-586-467; E-mail: yfchiu@nhri.org.tw

Publication History

  1. Issue published online: 12 APR 2013
  2. Article first published online: 18 JAN 2013
  3. Manuscript Accepted: 5 NOV 2012
  4. Manuscript Received: 7 FEB 2012

Funded by

  • National Science Council, Taiwan. Grant Number: NSC98-2118-M-400-002
  • National Health Research Institutes, Taiwan. Grant Number: PH-099-pp-04

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Additional supporting information may be found in the online version of this article:

FilenameFormatSizeDescription
ahg12008-sup-0001-TableS1.doc835KTable S1 LD structure between pair-wise markers and between a marker and the disease locus τ: the numbers in the upper triangle are D’, the numbers in the lower triangle are r2.
ahg12008-sup-0002-TableS2.doc37KTable S2 SNP information for ACE gene in the data example.
ahg12008-sup-0003-TableS3.doc86KTable S3 Robustness of population stratification Z-test with various nTr and ncc.

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