Liping Dong and Haoran Wang equally contributed to this work.
Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta-Analysis
Article first published online: 24 JAN 2013
© 2013 Blackwell Publishing Ltd/University College London
Annals of Human Genetics
Volume 77, Issue 3, pages 183–190, May 2013
How to Cite
Dong, L., Wang, H., Wang, D. W. and Ding, H. (2013), Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta-Analysis. Annals of Human Genetics, 77: 183–190. doi: 10.1111/ahg.12010
- Issue published online: 12 APR 2013
- Article first published online: 24 JAN 2013
- Manuscript Accepted: 9 NOV 2012
- Manuscript Received: 9 AUG 2012
- National Nature Science Foundation of China. Grant Numbers: 81100066, 2012CB518004, 2012AA02A510
- East Asian;
- coronary heart disease;
Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25–1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.