Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta-Analysis

Authors

  • Liping Dong,

    1. Department of Nephrology Puai Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China
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    • Liping Dong and Haoran Wang equally contributed to this work.

  • Haoran Wang,

    1. Departments of Internal Medicine Tongji Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China
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    • Liping Dong and Haoran Wang equally contributed to this work.

  • Dao Wen Wang,

    1. Departments of Internal Medicine Tongji Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China
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  • Hu Ding

    Corresponding author
    1. Departments of Internal Medicine Tongji Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China
    • Department of Nephrology Puai Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China
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Corresponding author: Hu Ding, PhD, MD, Department of Internal Medicine Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095# Jiefang Ave. 430030 Wuhan, People's Republic of China. Tel: 86-27-8366-3280; Fax: 86-27-8366-3280; E-mail: huding@tjh.tjmu.edu.cn

Summary

Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25–1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.

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