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Additional supporting information may be found in the online version of this article:

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Table S1 Genome-wide Association Results for AMD in the discovery, replication, and combined analyses.

Table S2 Genome-wide Association Results for AMD of Grade 5 AMD cases and Grade 1 controls in the discovery (720 Grade 5 cases/513 Grade 1 controls), replication (70 Grade 5 cases/73 Grade 1 controls), and combined (790 Grade 5 cases/586 Grade 1 controls) analyses.

Table S3 Genome-wide Results for tests of Gene-Environment Interaction with Ever/Never Smoking in the discovery dataset of 894 cases and 525 controls with data on smoking history.

Table S4 Genome-wide Results among only genotyped SNPs for tests of Gene-Environment Interaction with Ever/Never Smoking in the 2-df joint test and stratified datasets.

Table S5 Genome-wide Association Results among Genotyped and Imputed SNPs for AMD in the discovery, replication, and combined analyses.

Table S6 Genome-wide Results among genotyped and imputed SNPs for tests of Gene-Environment Interaction with Ever/Never Smoking in the 2-df joint test and stratified datasets.

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