Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients
Article first published online: 24 APR 2013
© 2013 John Wiley & Sons Ltd/University College London
Annals of Human Genetics
Volume 77, Issue 4, pages 344–350, July 2013
How to Cite
Zhang, J., Zhang, Y., Zhang, L., Yang, J., Ying, D., Zeng, S., Lee, T. L., Lau, C. S., Chan, T. M., Leung, A. M. H., Mok, C. C., Wong, S. N., Lee, K. W., Ho, M. H. K., Lee, P. P. W., Hon-Yin Chung, B., Chong, C. Y., Wong, R. W. S., Mok, M. Y., Wong, W. H. S., Lau, Y. L. and Yang, W. (2013), Epistatic Interaction between Genetic Variants in Susceptibility Gene ETS1 Correlates with IL-17 Levels in SLE Patients. Annals of Human Genetics, 77: 344–350. doi: 10.1111/ahg.12018
- Issue published online: 4 JUN 2013
- Article first published online: 24 APR 2013
- Manuscript Accepted: 14 DEC 2012
- Manuscript Received: 3 NOV 2012
- Shun Tak District Min Yuen Tong of Hong Kong
- Research Grant Council of the Hong Kong Government. Grant Numbers: GRF HKU781709M, HKU 784611M, HKU 770411M
- Edward Sai Kim Hotung Pediatric Education and Research
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Table S1 Results of epistatic interaction between rs10893872 and rs1128334 in Shanghai, Thailand and Anhui samples, using logistic regression implemented in PLINK.
Table S2 Meta-analysis of association studies in different cohorts of ETS1 variants.
Table S3 Multifactor dimensionality reduction (MDR) analysis for pairwise interactions in SLE patients and controls in Shanghai, Thailand and Anhui cohorts.
Figure S1 The optimal two-locus model as determined by MDR analysis on ETS1 variants in Shanghai, Thailand and Anhui cohorts.
Figure S2 Serum IL-17 concentration in SLE patients stratified by carrier status of rs1128334 genotype (a) or rs10893872 genotype (b).