Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in the ABO Blood Group Locus
Article first published online: 13 AUG 2013
© 2013 John Wiley & Sons Ltd/University College London
Annals of Human Genetics
Volume 77, Issue 6, pages 465–471, November 2013
How to Cite
Terao, C., Bayoumi, N., McKenzie, C. A., Zelenika, D., Muro, S., Mishima, M., The Nagahama Cohort Research Group, Connell, J. M. C., Vickers, M. A., Lathrop, G. M., Farrall, M., Matsuda, F. and Keavney, B. D. (2013), Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in the ABO Blood Group Locus. Annals of Human Genetics, 77: 465–471. doi: 10.1111/ahg.12034
- Issue published online: 6 OCT 2013
- Article first published online: 13 AUG 2013
- Manuscript Accepted: 16 MAY 2013
- Manuscript Received: 26 FEB 2013
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Takeda Science Foundation
- Wellcome Trust. Grant Number: 090532/Z/09/Z
- British Heart Foundation
- Genome Québec, le Ministère de l'Enseignement supérieur, de la Recherche, de la Science et de la Technologie (MESRST) Québec and McGill University
- Agence Nationale de la Recherche (ANR), France
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Table S1 Demographics of the Japanese discovery cohort.
Table S2 Demographics of the British replication cohort.
Table S3 Single-SNP analyses of GWAS SNPs at ACE and ABO loci in the Japanese cohort.
Figure S1 Manhattan plot of GWAS for plasma ACE in Japanese cohort, showing significant evidence of association at the ACE locus on Chromosome 17 and the ABO locus on Chromosome 9.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.