Associations Between Genetic Polymorphisms of Beta-2 Adrenergic Receptor and Preterm Delivery in Korean Women
Article first published online: 17 SEP 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 69, Issue 1, pages 85–91, January 2013
How to Cite
Associations between genetic polymorphisms of beta-2 adrenergic receptor and preterm delivery in Korean women. Am J Reprod Immunol 2013; 69: 85–91, , , , , .
- Issue published online: 7 DEC 2012
- Article first published online: 17 SEP 2012
- Manuscript Accepted: 13 AUG 2012
- Manuscript Received: 10 APR 2012
- National Research Foundation of Korea
- Ministry of Education Science and Technology. Grant Number: 2011-0004200
- Inha University. Grant Number: INHA-40898
- inflammatory cytokines;
- preterm delivery;
- uterine contraction
We investigated genetic polymorphisms to understand the etiology of preterm delivery, which involves inflammatory cytokines and uterine contraction. Maternal polymorphisms of ADRB2, iNOS, and eNOS were examined, and associations between these and the risk of preterm delivery were sought.
Method of Study
This study was performed on 166 Korean women who underwent preterm delivery and 289 normal controls. Logistic regression analyses were carried out to identify single genes and haplotypes that affect the risk of preterm delivery.
The G/G haplotype of ADRB2-rs1042713 and -rs1042714 was found to be associated with the risk of preterm delivery (OR = 1.90, 95% CI = 1.08–3.33, P-value = 0.0252). The genotype frequency of G allele in ADRB2-rs1042714 was associated with increased the risk of preterm delivery. However, after the adjustment of multiple comparison corrections, the association with preterm delivery was not remained significantly.
These findings possibly aid our understanding of the pathogenesis of preterm delivery and suggest that a haplotype with variants in maternal genes involved in adrenergic activation may lead to the dysregulation of uterine contractility and increase the risk of preterm delivery.