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Short Communication
A Search to Identify Genetic Risk Factors for Endometriosis
Article first published online: 20 NOV 2012
DOI: 10.1111/aji.12034
© 2012 John Wiley & Sons A/S
Additional Information
How to Cite
, , , , , , . A search to identify genetic risk factors for endometriosis. Am J Reprod Immunol 2013; 69: 92–95
Publication History
- Issue published online: 7 DEC 2012
- Article first published online: 20 NOV 2012
- Manuscript Accepted: 8 OCT 2012
- Manuscript Received: 31 AUG 2012
- Abstract
- Article
- References
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Keywords:
- Endometriosis;
- gene polymorphisms;
- p53codon72;
- SOD Ala16Val;
- TNF-308 G/A;
- VEGF-1154G/A
Problem
To search for molecular markers of endometriosis the following polymorphisms: p53 codon 72 Pro (apoptosis), TNF alpha-308 (inflammation), VEGF-1164AA (angiogenesis), and SOD2 (oxidative stress) were investigated.
Method of study
Forty-two women—24 with surgically proven endometriosis and 18 with no endometriosis found at the time of laparoscopy–had buccal swabs taken for DNA analyses of 4 gene polymorphisms including p53codon72, TNF-308 G/A, VEGF-1154G/A, SOD Ala16Val DNA. The frequencies of genotypes and alleles of these polymorphisms were compared between women with and without endometriosis.
Results
No specific gene mutation differences for the four genes tested nor differences in the frequencies of heterozygous and homozygous mutations were found between patients with endometriosis and controls. In addition, no differences in allelic frequencies of the four genetic polymorphisms were observed between patients with endometriosis and control.
Conclusion
Endometriosis is not associated with gene mutations for p53codon72, TNF-308 G/A, VEGF-1154G/A, SOD Ala16Val.