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Preimplantation Human Blastocyst-Endometrial Interactions: The Role of Inflammatory Mediators

Authors

  • Michelle Van Sinderen,

    1. Prince Henry's Institute of Medical Research, Melbourne, Vic., Australia
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    • These authors contributed equally to this work.
  • Ellen Menkhorst,

    1. Prince Henry's Institute of Medical Research, Melbourne, Vic., Australia
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    • These authors contributed equally to this work.
  • Amy Winship,

    1. Prince Henry's Institute of Medical Research, Melbourne, Vic., Australia
    2. Department of Anatomy and Developmental Biology, Monash University, Melbourne, Vic., Australia
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  • Carly Cuman,

    1. Prince Henry's Institute of Medical Research, Melbourne, Vic., Australia
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  • Evdokia Dimitriadis

    Corresponding author
    1. Department of Anatomy and Developmental Biology, Monash University, Melbourne, Vic., Australia
    • Prince Henry's Institute of Medical Research, Melbourne, Vic., Australia
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Correspondence

Evdokia Dimitriadis, Prince Henrys Institute of Medical Research, PO Box 5152, Melbourne, Vic. 3180, Australia.

E-mail: evdokia.dimitriadis@princehenrys.org

Abstract

Immune factors such as cytokines, chemokines, and growth factors are known to play important roles in the preimplantation interactions and communication between the blastocyst and receptive endometrium. This crucial dialog occurs during the stages when the blastocyst is in the uterine cavity immediately preceding implantation and the establishment of pregnancy. Human preimplantation processes are difficult to study due to restrictions on tissue availability. This review focuses on the expression and role of immune factors in human blastocyst-endometrial dialog during the very early stages of implantation. It highlights the importance of immune regulators and the need to develop new models to study human implantation.

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