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B7 Costimulation and Intracellular Indoleamine-2,3-Dioxygenase Expression in Peripheral Blood of Healthy Pregnant and Pre-Eclamptic Women

Authors


Correspondence

Gergely Toldi, First Department of Pediatrics, Semmelweis University,

Budapest, Bókay u. 53-54., H-1083, Hungary.

E-mail: toldigergely@yahoo.com

Abstract

Problem

We determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B-7H2, and that of T cells and T helper cells expressing CD28, CTLA-4, PD-1, and ICOS in peripheral blood samples from normal pregnant (NP) and pre-eclamptic (PE) women. We also examined the intracellular expression of indoleamine-2,3-dioxygenase (IDO).

Method of study

We measured the expression of the above markers using flow-cytometry in peripheral blood samples from 20 NP and 20 PE women in the third trimester.

Results

The frequency of B7-1 and B7-2 expressing activated monocytes and that of IDO expressing T-lymphocytes was lower in PE than in NP.

Conclusion

Lower expression of B7-1 and B7-2 proteins on peripheral monocytes in PE might indicate a secondary regulatory mechanism in response to the ongoing systemic maternal inflammation. IDO plays an important role in the pregnancy-specific immune tolerance, and might be a contributing factor in the pathogenesis of PE.

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