Pregnancy and Antiphospholipid Syndrome


  • Michael D. Lockshin

    Corresponding author
    • Department of Medicine and Obstetrics-Gynecology, Weill-Cornell Medical College, Hospital for Special Surgery New York, New York, NY, USA
    Search for more papers by this author

Correspondence Michael D. Lockshin, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA E-mail:


APS causes adverse pregnancy outcome, especially in younger patients with SLE or prior thromboses. LAC is the best predictor of adverse outcome. Prior conclusions on the efficacy of heparin for prevention of poor outcome may be suspect. New therapies are under evaluation in animal models but how to introduce them into the clinic is unclear.