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Keywords:

  • Antiphospholipid;
  • lupus;
  • lupus anticoagulant;
  • pregnancy

Abstract

APS causes adverse pregnancy outcome, especially in younger patients with SLE or prior thromboses. LAC is the best predictor of adverse outcome. Prior conclusions on the efficacy of heparin for prevention of poor outcome may be suspect. New therapies are under evaluation in animal models but how to introduce them into the clinic is unclear.