Viral invasion of the Amniotic Cavity (VIAC) in the Midtrimester of Pregnancy


  • Michelle Silasi

    Corresponding author
    • Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
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Michelle Silasi, MD, Reproductive Immunology Unit, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street FMB 329D, New Haven, CT 06520, USA.



A role for microbial invasion leading to inflammation in the amniotic cavity and subsequent pre-term delivery has been well established. For years, the role of viral infections in pregnancy has been minimized and thought of as harmless, with a few exceptions. Recent evidence now encourages us to expand our thinking and realize that viral infections during pregnancy may influence pregnancy more that we thought.