Expression of Apoptosis in Placenta of Experimental Antiphospholipid Syndrome Mouse
Article first published online: 8 FEB 2013
© 2013 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 69, Issue 5, pages 486–494, May 2013
How to Cite
Expression of apoptosis in placenta of experimental antiphospholipid syndrome mouse. Am J Reprod Immunol 2013; 69: 486–494., , , , , , .
- Issue published online: 12 APR 2013
- Article first published online: 8 FEB 2013
- Manuscript Accepted: 3 JAN 2013
- Manuscript Received: 15 SEP 2012
- Anticardiolipin antibodies;
- fetal loss;
- lupus anticoagulant;
- placental apoptosis;
To study the histopathology and expression of apoptosis in placenta of pregnancy-complicated antiphospholipid syndrome (APS)-positive mouse models.
Method of study
ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples.
Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen.
Our study showed the pathogenic role of aCL and LA in pregnancy complications.