Expression of Apoptosis in Placenta of Experimental Antiphospholipid Syndrome Mouse

Authors

  • Shanmugam Velayuthaprabhu,

    1. Department of Bio-Medical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, Tamil nadu, India
    2. Department of Obstetrics and Gynecology, Tokai University School of Medicine, Hachioji, Japan
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  • Hidehiko Matsubayashi,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Tokai University School of Medicine, Hachioji, Japan
    2. Katsuragawa Ladies Clinic, Shiga, Japan
    • Department of Bio-Medical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, Tamil nadu, India
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  • Toshitaka Sugi,

    1. Department of Obstetrics and Gynecology, Tokai University School of Medicine, Hachioji, Japan
    2. Sugi Women's Clinic, Yokohama, Japan
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  • Masato Nakamura,

    1. Department of Obstetrics and Gynecology, Tokai University School of Medicine, Hachioji, Japan
    2. Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan
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  • Yasuyuki Ohnishi,

    1. Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan
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  • Tomoyuki Ogura,

    1. Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan
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  • Govindaraju Archunan

    1. Department of Aniaml Science, Bharathidasan University, Tiruchirappalli, Tamil nadu, India
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Correspondence

Hidehiko Matsubayashi, Director, Hidehiko Matsubayashi MD, PhD, Katsuragawa Ladies Clinic, ART Center Lago, 21–8 Gotenhama, Ohtsu, Shiga 520-0834, Japan.

E-mail: matsubayashihide@me.com

Abstract

Problem

To study the histopathology and expression of apoptosis in placenta of pregnancy-complicated antiphospholipid syndrome (APS)-positive mouse models.

Method of study

ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples.

Results

Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen.

Conclusion

Our study showed the pathogenic role of aCL and LA in pregnancy complications.

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