Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature
Article first published online: 18 FEB 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Special Issue: Using Reproductive Immunology to Improve Clinical Practices
Volume 69, Issue 6, pages 545–557, June 2013
How to Cite
Cytokine levels in gestational diabetes mellitus: a systematic review of the literature. Am J Reprod Immunol 2013; 69: 545–557., , , , , .
- Issue published online: 10 MAY 2013
- Article first published online: 18 FEB 2013
- Manuscript Accepted: 9 JAN 2013
- Manuscript Received: 13 DEC 2012
- Fundação de Amparo à Pesquisa do Estado de São Paulo. Grant Number: 10/52547-5
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Blood specimen collection;
- gestational diabetes mellitus;
Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters.
Method of Study
Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed.
Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD = 0.45, 95% CI −0.34–1.23).
New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.