• 1
    Reis e Sousa C: Dendritic cells as sensors of infection. Immunity 2001; 14:495498.
  • 2
    Diebold S: Determination of T-cell fate by dendritic cells. Immunol Cell Biol 2008; 86:389397.
  • 3
    Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:23482357.
  • 4
    Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235238.
  • 5
    McGeachy M, Cua D: Th17 cell differentiation: the long and winding road. Immunity 2008; 28:445453.
  • 6
    Vanaudenaerde BM, Dupont LJ, Wuyts WA, Verbeken EK, Meyts I, Bullens DM, Dilissen E, Luyts L, Van Raemdonck DE, Verleden GM: The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J 2006; 27:779787.
  • 7
    Curtis M, Way S: Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009; 126:177185.
  • 8
    Sakaguchi S: Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6:345352.
  • 9
    Shevach EM: From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006; 25:195201.
  • 10
    Mor G, Cardenas I: The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010; 63:425433.
  • 11
    Matthiesen L, Berg G, Ernerudh J, Hakansson L: Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy. Am J Reprod Immunol 1996; 35:7079.
  • 12
    Bermas B, Hill J: Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion. J Clin Investig 1997; 100:13301334.
  • 13
    Porcu P, Gaddy J, Broxmeyer H: Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras. Proc Natl Acad Sci USA 1998; 95:45384543.
  • 14
    Mylonakis E, Paliou M, Hohmann E, Calderwood S, Wing E: Listeriosis during pregnancy: a case series and review of 222 cases. Medicine 2002; 81:260269.
  • 15
    Gellin B, Broome C, Bibb W, Weaver R, Gaventa S, Mascola L: The epidemiology of listeriosis in the United States–1986. Listeriosis Study Group. Am J Epidemiol 1991; 133:392401.
  • 16
    Wegmann TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353356.
  • 17
    Raghupathy R: Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18:478482.
  • 18
    Shiraishi H, Hayakawa S, Satoh K: Murine experimental abortion by IL-2 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis. J Clin Lab Immunol 1996; 48:93108.
  • 19
    Lin Y, Ren L, Wang W, Di J, Zeng S, Saito S: Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice. J Reprod Immunol 2009; 82:1223.
  • 20
    Bates M, Quenby S, Takakuwa K, Johnson P, Vince G: Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod 2002; 17:24392444.
  • 21
    Saini V, Arora S, Yadav A, Bhattacharjee J: Cytokines in recurrent pregnancy loss. Clin Chim Acta; Int J Clin Chem 2011; 412:702708.
  • 22
    van Mourik M, Macklon N, Heijnen C: Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol 2009; 85:419.
  • 23
    Ledee-Bataille N, Dubanchet S: Coulomb-L'hermine A, Durand-Gasselin I, Frydman R, Chaouat G: A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization. Fertil Steril 2004; 81:5965.
  • 24
    Wang W-J, Hao C-F, Yi L, Yin G-J, Bao S-H, Qiu L-H, Lin Q-D: Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J Reprod Immunol 2010; 84:164170.
  • 25
    Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S: Accumulation of IL-17-positive cells in decidua of inevitable abortion cases. Am J Reprod Immunol 2010; 64:411.
  • 26
    Saito S, Nakashima A, Shima T, Ito M: Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63:601610.
  • 27
    Zenclussen A, Gerlof K, Zenclussen M, Sollwedel A, Bertoja A, Ritter T, Kotsch K, Leber J, Volk H-D: Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 2005; 166:811822.
  • 28
    Somerset D, Zheng Y, Kilby M, Sansom DM, Drayson MT: Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004; 112: 3843.
  • 29
    Zhao J-X, Zeng Y-Y, Liu Y: Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J Reprod Immunol 2007; 75:7181.
  • 30
    Aluvihare V, Kallikourdis M, Betz A: Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004; 5:266271.
  • 31
    Tilburgs T, Roelen D, van der Mast B, de Groot-Swings G, Kleijburg C, Scherjon S, Claas F: Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 2008; 180:57375745.
  • 32
    Jasper M, Tremellen K, Robertson SA: Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12:301308.
  • 33
    Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S: Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10:347353.
  • 34
    Yang H, Qiu L, Chen G, Ye Z, Lu C, Lin Q: Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients. Fertil Steril 2008; 89:656661.
  • 35
    Hsu P, Santner-Nanan B, Dahlstrom J, Fadia M, Chandra A, Peek M, Nanan R: Altered Decidual DC-SIGN(+) Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. Am J Pathol 2012; 181:21492160.
  • 36
    Arruvito L, Sanz M, Banham A, Fainboim L: Expansion of CD4+CD25+ and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J Immunol 2007; 178:25722578.
  • 37
    Samstein R, Josefowicz S, Arvey A, Treuting P, Rudensky A: Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 2012; 150:2938.
  • 38
    Peck A, Mellins E: Plasticity of T-cell phenotype and function: the T helper type 17 example. Immunology 2010; 129:147153.
  • 39
    Mao G, Wang J, Kang Y, Tai P, Wen J, Zou Q, Li G, Ouyang H, Xia G, Wang B: Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice. Endocrinology 2010; 151:54775488.
  • 40
    Wan H, Versnel MA, Leijten LME, van Helden-Meeuwsen CG, Fekkes D, Leenen PJM, Khan NA, Benner R, Kiekens RCM: Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype. J Leukoc Biol 2008; 83:894901.
  • 41
    Darmochwal-Kolarz D, Kludka-Sternik M, Tabarkiewicz J, Kolarz B, Rolinski J, Leszczynska-Gorzelak B, Oleszczuk J: The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia. J Reprod Immunol 2012; 93:7581.
  • 42
    Blois SM, Ilarregui JM, Tometten M, Garcia M, Orsal AS, Cordo-Russo R, Toscano MA, Bianco GA, Kobelt P, Handjiski B, Tirado I, Markert UR, Klapp BF, Poirier F, Szekeres-Bartho J, Rabinovich GA, Arck PC: A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 2007; 13:14501457.
  • 43
    Ermisch C, Markert U: PIBF – Progesterone-Induced Blocking Factor. Z Geburtshilfe Neonatol 2011; 215:9397.
  • 44
    Sacks G, Sargent I, Redman C: An innate view of human pregnancy. Immunol Today 1999; 20:114118.
  • 45
    Liang J, Sun L, Wang Q, Hou Y: Progesterone regulates mouse dendritic cells differentiation and maturation. Int Immunopharmacol 2006; 6:830838.
  • 46
    Siiteri P, Febres F, Clemens L, Chang R, Gondos B, Stites D: Progesterone and maintenance of pregnancy: is progesterone nature's immunosuppressant? Ann NY Acad Sci 1977; 286:384397.
  • 47
    Branch D: Physiologic adaptations of pregnancy. Am J Reprod Immunol 1992; 28:120122.
  • 48
    Zhou G, HammarstrÃm S: Pregnancy-specific glycoprotein (PSG) in baboon (Papio hamadryas): family size, domain structure, and prediction of a functional region in primate PSGs. Biol Reprod 2001; 64:9099.
  • 49
    Camolotto S, Racca A, Rena V, Nores R, Patrito L, Genti-Raimondi S, Panzetta-Dutari G: Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells. Placenta 2010; 31:312319.
  • 50
    Lin T, Halbert S, Spellacy W: Measurement of pregnancy-associated plasma proteins during human gestation. J Clin Investig 1974; 54:576582.
  • 51
    Arnold L, Doherty T, Flor A, Simon J, Chou J, Chan W, Mansfield B: Pregnancy-specific glycoprotein gene expression in recurrent aborters: a potential correlation to interleukin-10 expression. Am J Reprod Immunol 1999; 41:174182.
  • 52
    Silver RM, Heyborne KD, Leslie KK: Pregnancy specific beta 1 glycoprotein (SP-1) in maternal serum and amniotic fluid; pre-eclampsia, small for gestational age fetus and fetal distress. Placenta 1993; 14:583589.
  • 53
    Tamsen L, Johansson S, Axelsson O: Pregnancy-specific beta 1-glycoprotein (SP1) in serum from women with pregnancies complicated by intrauterine growth retardation. J Perinat Med 1983; 11:1925.
  • 54
    Pihl K, Larsen T, Laursen I, Krebs L, Christiansen M: First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. Prenat Diagn 2009; 29:12561261.
  • 55
    McLellan A, Zimmermann W, Moore T: Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates. BMC Evol Biol 2005; 5:39.
  • 56
    Teglund S, Olsen A, Khan W: Frängsmyr L, Hammarstrom S: The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. Genomics 1994; 23:669684.
  • 57
    Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, HammarstrÃm S, Holmes K, Karlsson A, Kuroki M, Lin S, Lucka L, Najjar S, Neumaier M, Obrink B, Shively J, Skubitz K, Stanners C, Thomas P, Thompson J, Virji M, von Kleist S, Wagener C, Watt S, Zimmermann W: Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 1999; 252:243249.
  • 58
    Grudzinskas J, Lenton E, Gordon Y, Kelso I, Jeffrey D, Sobowale O, Chard T: Circulating levels of pregnancy-specific beta1-glycoprotein in early pregnancy. Br J Obstet Gynaecol 1977; 84:740742.
  • 59
    Bocco J, Panzetta G, Flury A, Patrito L: Expression of pregnancy specific beta 1-glycoprotein gene in human placenta and hydatiform mole. Biochem Int 1989; 18:9991008.
  • 60
    Bohn H, Weinmann E: Antifertility effect of an active immunization of monkeys with human pregnancy-specific beta 1-glycoprotein (SP1) (author's transl). Archiv für Gynäkologie 1976; 221:305312.
  • 61
    Horne CH, Towler CM, Pugh-Humphreys RG, Thomson AW, Bohn H: Pregnancy specific beta1-glycoprotein–a product of the syncytiotrophoblast. Experientia 1976; 32:1197.
  • 62
    Harris S, Anthony F, Jones D, Masson G: Pregnancy-specific-beta 1-glycoprotein: effect on lymphocyte proliferation in vitro. J Reprod Immunol 1984; 6:267270.
  • 63
    Cerni C, Tatra G, Bohn H: Immunosuppression by human placenta lactogen (HPL) and the pregnancy-specific beta 1-glycoprotein (SP-1). Inhibition of mitogen-induced lymphocyte transformation. Archiv für Gynäkologie 1977; 223:17.
  • 64
    Marchal I, Jarvis D, Cacan R, Verbert A: Glycoproteins from insect cells: sialylated or not? Biol Chem 2001; 382:151159.
  • 65
    Fialova L, Kohoutova B, Pelaskova Z, Malbohan I, Mikulakova L: [Serum levels of trophoblast-specific beta-1-globulin (SP1) and alpha-1-fetoprotein (AFP) in pregnant women with rheumatoid arthritis]. Ceskoslovenská Gynekologie 1991; 56:166170.
  • 66
    Bebo B, Dveksler G: Evidence that pregnancy specific glycoproteins regulate T-Cell function and inflammatory autoimmune disease during pregnancy. Curr Drug Targets Inflamm Allergy 2005; 4:231237.
  • 67
    Rutherfurd K, Chou J, Mansfield B: A motif in PSG11s mediates binding to a receptor on the surface of the promonocyte cell line THP-1. Mol Endocrinol 1995; 9:12971305.
  • 68
    Waterhouse R, Ha C, Dveksler GS: Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. J Exp Med 2002; 195:277282.
  • 69
    Ha CT, Waterhouse R, Warren J, Zimmermann W, Dveksler GS: N-glycosylation is required for binding of murine pregnancy-specific glycoproteins 17 and 19 to the receptor CD9. Am J Reprod Immunol 2008; 59:251258.
  • 70
    Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS: Pregnancy-specific Glycoprotein 1 Induces Endothelial Tubulogenesis through Interaction with Cell Surface Proteoglycans. J Biol Chem 2011; 286:75777586.
  • 71
    Sulkowski G, Warren J, Ha C, Dveksler G: Characterization of receptors for murine pregnancy specific glycoproteins 17 and 23. Placenta 2011; 32:603610.
  • 72
    Wu JA, Johnson BL, Chen Y, Ha CT, Dveksler GS: Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod 2008; 79:10541061.
  • 73
    Blois S, Tirado-Gonzalez I, Wu J, Barrientos G, Johnson B, Warren J, Freitag N, Klapp B, Irmak S, Ergun S, Dveskler G: Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice. Biol Reprod 2012; 86:191.
  • 74
    Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS: Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol Reprod 2010; 83:2735.
  • 75
    Motran CC, Diaz FL, Gruppi A, Slavin D, Chatton B, Bocco JL: Human pregnancy-specific glycoprotein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell-dependent T cell proliferation. J Leukoc Biol 2002; 72:512521.
  • 76
    Watanabe S, Chou JY: Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein. J Biol Chem 1988; 263:20492054.
  • 77
    Motran CC, Diaz FL, Montes CL, Bocco JL, Gruppi A: In vivo expression of recombinant pregnancy-specific glycoprotein 1a induces alternative activation of monocytes and enhances Th2-type immune response. Eur J Immunol 2003; 33:30073016.
  • 78
    Yip HC, Karulin AY, Tary-Lehmann M, Hesse MD, Radeke H, Heeger PS, Trezza RP, Heinzel FP, Forsthuber T, Lehmann PV: Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response. J Immunol 1999; 162:39423949.
  • 79
    Kovarik J, Gaillard M, Martinez X, Bozzotti P, Lambert PH, Wild TF, Siegrist CA: Induction of adult-like antibody, Th1, and CTL responses to measles hemagglutinin by early life murine immunization with an attenuated vaccinia-derived NYVAC(K1L) viral vector. Virology 2001; 285:1220.
  • 80
    Geginat G, Lalic M, Kretschmar M, Goebel W, Hof H, Palm D, Bubert A: Th1 Cells Specific for a Secreted Protein of Listeria monocytogenes Are Protective In Vivo. J Immunol 1998; 160:60466055.
  • 81
    Martínez FF, Knubel CP, Sánchez MC, Cervi L, Motrán CC: Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization. Eur J Immunol 2012; 42:15731584.
  • 82
    Ertelt JM, Rowe JH, Johanns TM, Lai JC, McLachlan JB, Way SS: Selective Priming and Expansion of Antigen-Specific Foxp3-CD4+ T Cells during Listeria monocytogenes Infection. J Immunol 2009; 182:30323038.
  • 83
    Collins M, Tay C, Erlebacher A: Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. J Clin Invest 2009; 119:20622073.
  • 84
    Pongcharoen S, Niumsup P, Sanguansermsri D, Supalap K, Butkhamchot P: The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells. Am J Reprod Immunol 2006; 55:291300.
  • 85
    Numasaki M, Fukushi J, Ono M, Narula SK, Zavodny PJ, Kudo T, Robbins PD, Tahara H, Lotze MT: Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003; 101:26202627.
  • 86
    Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H: IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 2009; 206:14571464.
  • 87
    Huber S, Gagliani N, Esplugues E, O'Connor W, Huber Francis J, Chaudhry A, Kamanaka M, Kobayashi Y, Booth Carmen J, Rudensky Alexander Y, Roncarolo Maria G, Battaglia M, Flavell Richard A: Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3 and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner. Immunity 2011;34:554565.
  • 88
    Chaudhry A, Samstein Robert M, Treuting P, Liang Y, Pils Marina C, Heinrich J-M, Jack Robert S, Wunderlich FT, Brüning Jens C, Müller W, Rudensky Alexander Y: Interleukin-10 signaling in regulatory T cells is required for suppression of TH17 cell-mediated inflammation. Immunity 2011; 34:566578.
  • 89
    Ha CT, Waterhouse R, Wessells J, Wu JA, Dveksler GS: Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. J Leukoc Biol 2005; 77:948957.
  • 90
    Snyder SK, Wessner DH, Wessells JL, Waterhouse RM, Wahl LM, Zimmermann W, Dveksler GS: Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes. Am J Reprod Immunol 2001; 45:205216.
  • 91
    Wessells J, Wessner D, Parsells R, White K, Finkenzeller D, Zimmermann W, Dveksler G: Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages. Eur J Immunol 2000; 30:18301840.
  • 92
    Goerdt S, Orfanos CE: Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 1999; 10:137142.
  • 93
    Munder M, Eichmann K, Modolell M: Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol 1998; 160:53475354.
  • 94
    Tiemessen M, Jagger A, Evans H, van Herwijnen M, John S, Taams L: CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 2007; 104:1944619451.
  • 95
    Stein M, Keshav S, Harris N, Gordon S: Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992; 176:287292.
  • 96
    Mosser D, Edwards J: Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8:958969.
  • 97
    Mues B, Langer D, Zwadlo G, Sorg C: Phenotypic characterization of macrophages in human term placenta. Immunology 1989; 67:303307.
  • 98
    Cua DJ, Stohlman SA: In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets. J Immunol 1997; 159:58345840.
  • 99
    Loke P, MacDonald AS, Robb A, Maizels RM, Allen JE: Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact. Eur J Immunol 2000; 30:26692678.
  • 100
    Brunialti M, Santos M, Rigato O, Machado F, Silva E, Salomao R: Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis. PLoS ONE 2012; 7:e37393.
  • 101
    van de Veerdonk F, Marijnissen R, Kullberg B, Koenen H, Cheng S-C, Joosten I, van den Berg W, Williams D, van der Meer J, Joosten L, Netea M: The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 2009; 5:329340.
  • 102
    Loke P, MacDonald AS, Allen JE: Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naive CD4(+) T cells. Eur J Immunol 2000; 30:11271135.
  • 103
    Taylor MD, Harris A, Babayan SA, Bain O, Culshaw A, Allen JE, Maizels RM: CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. J Immunol 2007; 179:46264634.
  • 104
    Steinman RM, Hawiger D, Nussenzweig MC: Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21:685711.
  • 105
    Krey G, Frank P, Shaikly V, Barrientos G, Cordo-Russo R, Ringel F, Moschansky P, Chernukhin I, Metodiev M, Fernandez N, Klapp B, Arck P, Blois S: In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice. J Mol Med 2008; 86:9991011.
  • 106
    Nevers T, Kalkunte S, Sharma S: Uterine Regulatory T cells, IL-10 and hypertension. Am J Reprod Immunol 2011; 66(Suppl 1):8892.
  • 107
    Barrientos G, Tirado-Gonzalez I, Klapp BF, Karimi K, Arck PC, Garcia MG, Blois SM: The impact of dendritic cells on angiogenic responses at the fetal-maternal interface. J Reprod Immunol 2009; 83:8594.
  • 108
    Blois SM, Alba Soto CD, Tometten M, Klapp BF, Margni RA, Arck PC: Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy. Biol Reprod 2004;70:10181023.
  • 109
    Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ: The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007; 8:239245.
  • 110
    Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT: Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441:231234.
  • 111
    MacDonald AS, Maizels RM: Alarming dendritic cells for Th2 induction. J Exp Med 2008; 205:1317.
  • 112
    Constant SL, Brogdon JL, Piggott DA, Herrick CA, Visintin I, Ruddle NH, Bottomly K: Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J Clin Invest 2002; 110:14411448.
  • 113
    Iwasaki A, Kelsall BL: Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med 1999; 190:229239.
  • 114
    Conejo-Garcia JR, Benencia F, Courreges MC, Kang E, Mohamed-Hadley A, Buckanovich RJ, Holtz DO, Jenkins A, Na H, Zhang L, Wagner DS, Katsaros D, Caroll R, Coukos G: Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med 2004; 10:950958.
  • 115
    Koga K, Mor G: Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders. Am J Reprod Immunol 2010; 63:587600.
  • 116
    Petroff MG, Chen L, Phillips TA, Azzola D, Sedlmayr P, Hunt JS: B7 Family Molecules Are Favorably Positioned at the Human Maternal-Fetal Interface. Biol Reprod 2003; 68:14961504.
  • 117
    Guleria I, Khosroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH: A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med 2005; 202:231237.
  • 118
    Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH: PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206:30153029.
  • 119
    Schreiner B, Bailey S, Shin T, Chen L, Miller S: PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. Eur J Immunol 2008; 38:27062717.
  • 120
    Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, Benoit S, Ireland G, Luxenberg D, Askew GR, Milarski KL, Groves C, Brown T, Carito BA, Percival K, Carreno BM, Collins M, Marusic S: PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol 2007; 182:124134.
  • 121
    Cork B, Tuckerman E, Li T, Laird S: Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro. Mol Hum Reprod 2002; 8:841848.
  • 122
    Rincon M, Anguita J, Nakamura T, Fikrig E, Flavell RA: Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med 1997; 185:461469.
  • 123
    Frick JS, Zahir N, Müller M, Kahl F, Bechtold O, Lutz MB, Kirschning CJ, Reimann J, Jilge B, Bohn E, Autenrieth IB: Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6. Eur J Immunol 2006; 36:15371547.