SEARCH

SEARCH BY CITATION

References

  • 1
    Terness P, Kallikourdis M, Betz AG, Rabinovich GA, Saito S, Clark DA: Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells. Am J Reprod Immunol 2007; 58:238254.
  • 2
    Chaouat G, Petitbarat M, Dubanchet S, Rahmati M, Ledée N: Tolerance to the foetal allograft? Am J Reprod Immunol 2010; 63:624636.
  • 3
    Blois SM, Joachim R, Kandil J, Margni R, Tometten M, Klapp BF, Arck PC: Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile. J Immunol 2004; 172:58935899.
  • 4
    Chaouat G: The Th1/Th2 paradigm: still important in pregnancy? Semin Immunopathol 2007; 29:95113.
  • 5
    Aluvihare VR, Kallikourdis M, Betz AG: Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004; 5:266271.
  • 6
    Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Bertoja AZ, Ritter T, Kotsch K, Leber J, Volk HD: Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+ CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 2005; 166:811822.
  • 7
    Kallikourdis M, Andersen KG, Welch KA, Betz AG: Alloantigen-enhanced accumulation of CCR5+ ‘effector’ regulatory T cells in the gravid uterus. Proc Natl Acad Sci U S A. 2007; 104:594599.
  • 8
    Fainboim L, Arruvito L: Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling. J Reprod Immunol 2011; 88:9398.
  • 9
    Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL: Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 2003; 198:12011212.
  • 10
    Guleria I, Khosroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH: A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med 2005; 202:231237.
  • 11
    Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A: Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. J Immunol 2003; 171:23052313.
  • 12
    Phillips TA, Ni J, Pan G, Ruben SM, Wei YF, Pace JL, Hunt JS: TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege. J Immunol 1999; 162:60536059.
  • 13
    Tariverdian N, Theoharides TC, Siedentopf F, Gutiérrez G, Jeschke U, Rabinovich GA, Blois SM, Arck PC: Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach. Semin Immunopathol 2007; 29:193210.
  • 14
    Arck PC, Gilhar A, Bienenstock J, Paus R: The alchemy of immune privilege explored from a neuroimmunological perspective. Curr Opin Pharmacol 2008; 8:480489.
  • 15
    Fraccaroli L, Alfieri J, Larocca L, Calafat M, Roca V, Lombardi E, Ramhorst R, Leirós CP: VIP modulates the pro-inflammatory maternal response, inducing tolerance to trophoblast cells. Br J Pharmacol 2009; 156:116126.
  • 16
    Arck P, Hansen PJ, Mulac Jericevic B, Piccinni MP, Szekeres-Bartho J: Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am J Reprod Immunol 2007; 58:268279.
  • 17
    Arruvito L, Giulianelli S, Flores AC, Paladino N, Barboza M, Lanari C, Fainboim L: NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis. J Immunol 2008; 180:57465753.
  • 18
    Zenclussen AC, Schumacher A, Zenclussen ML, Wafula P, Volk HD: Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus. Expert Rev Mol Med 2007; 9:114.
  • 19
    Nakamura K, Sheps S, Arck PC: Stress and reproductive failure: past notions, present insights and future directions. J Assist Reprod Genet 2008; 25:4762.
  • 20
    Oreshkova T, Dimitrov R, Mourdjeva M: A cross-talk of decidual stromal cells, trophoblast, and immune cells: a prerequisite for the success of pregnancy. Am J Reprod Immunol 2012; 68:366373.
  • 21
    Rabinovich GA, Croci DO: Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity 2012; 36:322335.
  • 22
    Meseguer M, Pellicer A, Simón C: MUC1 and endometrial receptivity. Mol Hum Reprod 1998; 4:10891098.
  • 23
    Toscano MA, Ilarregui JM, Bianco GA, Campagna L, Croci DO, Salatino M, Rabinovich GA: Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity? Cytokine Growth Factor Rev 2007; 18:5771.
  • 24
    Rabinovich GA, Toscano MA, Jackson SS, Vasta GR: Functions of cell surface galectin-glycoprotein lattices. Curr Opin Struct Biol 2007; 17:513520.
  • 25
    Dam TK, Brewer CF: Lectins as pattern recognition molecules: the effects of epitope density in innate immunity. Glycobiology 2010; 20:270279.
  • 26
    Dennis JW, Nabi IR, Demetriou M: Metabolism, cell surface organization, and disease. Cell 2009; 139:12291241.
  • 27
    Rabinovich GA, Toscano MA: Turning ‘sweet’ on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009; 9:338352.
  • 28
    Liu FT, Rabinovich GA: Galectins: regulators of acute and chronic inflammation. Ann N Y Acad Sci 2010; 1183:158182.
  • 29
    Yang RY, Rabinovich GA, Liu FT: Galectins: structure, function and therapeutic potential. Expert Rev Mol Med 2008; 10:e17.
  • 30
    Hirabayashi J, Hashidate T, Arata Y, Nishi N, Nakamura T, Hirashima M, Urashima T, Oka T, Futai M, Muller WE, Yagi F, Kasai K: Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta 2002; 1572:232254.
  • 31
    Stowell SR, Arthur CM, Mehta P, Slanina KA, Blixt O, Leffler H, Smith DF, Cummings RD: Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem 2008; 283:1010910123.
  • 32
    Di Lella S, Sundblad V, Cerliani JP, Guardia CM, Estrin DA, Vasta GR, Rabinovich GA: When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 2011; 50:78427857.
  • 33
    Rabinovich GA, Daly G, Dreja H, Tailor H, Riera CM, Hirabayashi J, Chernajovsky Y: Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999; 190:385398.
  • 34
    Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM, Hirabayashi J, Rizzo LV, Rabinovich GA: Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J Immunol 2006; 176:63236332.
  • 35
    Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA: Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 2007; 8:825834.
  • 36
    Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE: Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 2009; 182:26412653.
  • 37
    Starossom SC, Mascanfroni ID, Imitola J, Cao L, Raddassi K, Hernandez SF, Bassil R, Croci DO, Cerliani JP, Delacour D, Wang Y, Elyaman W, Khoury SJ, Rabinovich GA: Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity 2012; 37:249263.
  • 38
    Seropian IM, Cerliani JP, Toldo S, Van Tassell BW, Ilarregui JM, González GE, Matoso M, Salloum FN, Melchior R, Gelpi RJ, Stupirski JC, Benatar A, Gómez KA, Morales C, Abbate A, Rabinovich GA: Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction. Am J Pathol 2013; 182:2940.
  • 39
    Rubinstein N, Alvarez M, Zwirner NW, Toscano MA, Ilarregui JM, Bravo A, Mordoh J, Fainboim L, Podhajcer OL, Rabinovich GA: Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege. Cancer Cell 2004; 5:241251.
  • 40
    Juszczynski P, Ouyang J, Monti S, Rodig SJ, Takeyama K, Abramson J, Chen W, Kutok JL, Rabinovich GA, Shipp MA: The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2007; 104:1313413139.
  • 41
    Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT: Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Res 2011; 71:44234431.
  • 42
    Soldati R, Berger E, Zenclussen AC, Jorch G, Lode HN, Salatino M, Rabinovich GA, Fest S: Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments. Int J Cancer 2012; 131:11311141.
  • 43
    Dalotto-Moreno T, Croci DO, Cerliani JP, Martinez-Allo VC, Dergan-Dylon S, Mendez Huergo SP, Stupirski JC, Mazal D, Osinaga E, Toscano MA, Sundblad V, Rabinovich GA, Salatino M: Targeting galectin-1 overcomes breast cancer associated immunosuppression and prevents metastatic disease. Cancer Res 2013; 73:11071117.
  • 44
    Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA: Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10:981991.
  • 45
    Liu SD, Lee S, La Cava A, Motran CC, Hahn BH, Miceli MC: Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB × NZW) F1 mice fromlupus-like disease. Lupus 2011; 20:473484.
  • 46
    Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O: Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 1999; 97:100106.
  • 47
    Norling LV, Sampaio AL, Cooper D, Perretti M: Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J 2008; 22:682690.
  • 48
    He J, Baum LG: Galectin interactions with extracellular matrix and effects on cellular function. Methods Enzymol 2006; 417:247256.
  • 49
    van der Leij J, van den Berg A, Harms G, Eschbach H, Vos H, Zwiers P, van Weeghel R, Groen H, Poppema S, Visser L: Strongly enhanced IL-10 production using stable galectin-1 homodimers. Mol Immunol 2007; 44:506513.
  • 50
    Stowell SR, Qian Y, Karmakar S, Koyama NS, Dias-Baruffi M, Leffler H, McEver RP, Cummings RD: Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol 2008; 180:30913102.
  • 51
    Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ: Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 2012; 188:31273137.
  • 52
    Rabinovich GA, Ilarregui JM: Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments. Immunol Rev 2009; 230:144159.
  • 53
    Than NG, Romero R, Kim CJ, McGowen MR, Papp Z, Wildman DE: Galectins: guardians of eutherian pregnancy at the maternal-fetal interface. Trends Endocrinol Metab 2012; 23:2331.
  • 54
    Phillips B, Knisley K, Weitlauf KD, Dorsett J, Lee V, Weitlauf H: Differential expression of two beta-galactoside-binding lectins in the reproductive tracts of pregnant mice. Biol Reprod 1996; 55:548558.
  • 55
    Dettin L, Rubinstein N, Aoki A, Rabinovich GA, Maldonado CA: Regulated expression and ultrastructural localization of galectin-1, a proapoptotic beta-galactoside-binding lectin, during spermatogenesis in rat testis. Biol Reprod 2003; 68:5159.
  • 56
    Maquoi E, van den Brûle FA, Castronovo V, Foidart JM: Changes in the distribution pattern of galectin-1 and galectin-3 in human placenta correlates with the differentiation pathways of trophoblasts. Placenta 1997; 18:433439.
  • 57
    Iglesias MM, Rabinovich GA, Ivanovic V, Sotomayor C, Wolfenstein-Todel C: Galectin-1 from ovine placenta–amino-acid sequence, physicochemical properties and implications in T-cell death. Eur J Biochem 1998; 252:400407.
  • 58
    Bozić M, Petronijević M, Milenković S, Atanacković J, Lazić J, Vićovac LJ: Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease. Placenta 2004; 25:797802.
  • 59
    von Wolff M, Wang X, Gabius HJ, Strowitzki T: Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation. Mol Hum Reprod 2005; 11:189194.
  • 60
    Dong M, Ding G, Zhou J, Wang H, Zhao Y, Huang H: The effect of trophoblasts on T lymphocytes: possible regulatory effector molecules–a proteomic analysis. Cell Physiol Biochem 2008; 21:463472.
  • 61
    Tirado-González I, Freitag N, Barrientos G, Shaikly V, Nagaeva O, Strand M, Kjellberg L, Klapp BF, Mincheva-Nilsson L, Cohen M, Blois SM: Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy. Mol Hum Reprod 2013; 19:4353.
  • 62
    Garín MI, Chu CC, Golshayan D, Cernuda-Morollón E, Wait R, Lechler RI: Galectin-1: a key effector of regulation mediated by CD4+ CD25+ T cells. Blood 2007; 109:20582065.
  • 63
    Fuertes MB, Molinero LL, Toscano MA, Ilarregui JM, Rubinstein N, Fainboim L, Zwirner NW, Rabinovich GA: Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase. Mol Cell Biochem 2004; 267:177185.
  • 64
    Rabinovich GA, Castagna L, Landa C, Riera CM, Sotomayor C: Regulated expression of a 16-kd galectin-like protein in activated rat macrophages. J Leukoc Biol 1996; 59:363370.
  • 65
    Karimi K, Arck PC: Natural Killer cells: keepers of pregnancy in the turnstile of the environment. Brain Behav Immun 2010; 24:339347.
  • 66
    Bevan BH, Kilpatrick DC, Liston WA, Hirabayashi J, Kasai K: Immunohistochemical localization of a beta-D-galactoside-binding lectin at the human maternofetal interface. Histochem J 1994; 26:582586.
  • 67
    Ramhorst RE, Giribaldi L, Fraccaroli L, Toscano MA, Stupirski JC, Romero MD, Durand ES, Rubinstein N, Blaschitz A, Sedlmayr P, Genti-Raimondi S, Fainboim L, Rabinovich GA: Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss. Glycobiology 2012; 22:13741386.
  • 68
    Poirier F, Timmons PM, Chan CT, Guénet JL, Rigby PW: Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre- and post-implantation development. Development 1992; 115:143155.
  • 69
    Poirier F, Robertson EJ: Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development 1993; 119:12291236.
  • 70
    Blois SM, Ilarregui JM, Tometten M, Garcia M, Orsal AS, Cordo-Russo R, Toscano MA, Bianco GA, Kobelt P, Handjiski B, Tirado I, Markert UR, Klapp BF, Poirier F, Szekeres-Bartho J, Rabinovich GA, Arck PC: A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 2007; 13:14501457.
  • 71
    Kopcow HD, Rosetti F, Leung Y, Allan DS, Kutok JL, Strominger JL: T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1. Proc Natl Acad Sci USA 2008; 105:1847218477.
  • 72
    Woidacki K, Popovic M, Metz M, Schumacher A, Linzke N, Teles A, Poirier F, Fest S, Jensen F, Rabinovich GA, Maurer M, Zenclussen AC: Mast cells rescue implantation defects caused by c-kit deficiency. Cell Death Dis 2013; 4:e462.
  • 73
    Than NG, Romero R, Erez O, Weckle A, Tarca AL, Hotra J, Abbas A, Han YM, Kim SS, Kusanovic JP, Gotsch F, Hou Z, Santolaya-Forgas J, Benirschke K, Papp Z, Grossman LI, Goodman M, Wildman DE: Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. Proc Natl Acad Sci USA 2008; 105:1581915824.
  • 74
    Hirota Y, Burnum KE, Acar N, Rabinovich GA, Daikoku T, Dey SK: Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52. Endocrinology 2012; 153:24862493.
  • 75
    Jeschke U, Reimer T, Bergemann C, Wiest I, Schulze S, Friese K, Walzel H: Binding of galectin-1 (gal-1) on trophoblast cells and inhibition of hormone production of trophoblast tumor cells in vitro by gal-1. Histochem Cell Biol 2004; 121:501508.
  • 76
    Kolundžić N, Bojić-Trbojević Ž, Kovačević T, Stefanoska I, Kadoya T, Vićovac L: Galectin-1 is part of human trophoblast invasion machinery–a functional study in vitro. PLoS ONE 2011; 6:e28514.
  • 77
    Fischer I, Weber M, Kuhn C, Fitzgerald JS, Schulze S, Friese K, Walzel H, Markert UR, Jeschke U: Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo. Mol Hum Reprod 2011; 17:747757.
  • 78
    Thijssen VL, Barkan B, Shoji H, Aries IM, Mathieu V, Deltour L, Hackeng TM, Kiss R, Kloog Y, Poirier F, Griffioen AW: Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res 2010; 70:62166224.
  • 79
    Mathieu V, de Lassalle EM, Toelen J, Mohr T, Bellahcène A, Van Goietsenoven G, Verschuere T, Bouzin C, Debyser Z, De Vleeschouwer S, Van Gool S, Poirier F, Castronovo V, Kiss R, Feron O: Galectin-1 in melanoma biology and related neo-angiogenesis processes. J Invest Dermatol 2012; 132:22452254.
  • 80
    Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA: Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med 2012; 209:19852000.
  • 81
    Laderach DJ, Gentilini LD, Giribaldi L, Delgado VC, Nugnes L, Croci DO, Al Nakouzi N, Sacca P, Casas G, Mazza O, Shipp MA, Vazquez E, Chauchereau A, Kutok JL, Rodig SJ, Elola MT, Compagno D, Rabinovich GA: A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease. Cancer Res 2013; 73:8696.
  • 82
    Zhao XY, Zhao KW, Jiang Y, Zhao M, Chen GQ: Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem 2011; 286:3680836819.
  • 83
    Cooper D, Norling LV, Perretti M: Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol 2008; 83:14591466.
  • 84
    Vasta GR, Ahmed H, Nita-Lazar M, Banerjee A, Pasek M, Shridhar S, Guha P, Fernández-Robledo JA: Galectins as self/non-self recognition receptors in innate and adaptive immunity: an unresolved paradox. Front Immunol 2012; 3:199.
  • 85
    Pacienza N, Pozner RG, Bianco GA, D'Atri LP, Croci DO, Negrotto S, Malaver E, Gómez RM, Rabinovich GA, Schattner M: The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. FASEB J 2008; 22:11131123.
  • 86
    Lobsanov YD, Gitt MA, Leffler H, Barondes SH, Rini JM: X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. J Biol Chem 1993; 268:2703427038.
  • 87
    Paclik D, Berndt U, Guzy C, Dankof A, Danese S, Holzloehner P, Rosewicz S, Wiedenmann B, Wittig BM, Dignass AU, Sturm A: Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice. J Mol Med (Berl) 2008; 86:13951406.
  • 88
    Paclik D, Lohse K, Wiedenmann B, Dignass AU, Sturm A: Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism. Inflamm Bowel Dis 2008; 14:13661372.
  • 89
    Ochieng J, Green B, Evans S, James O, Warfield P: Modulation of the biological functions of galectin-3 by matrix metalloproteinases. Biochim Biophys Acta 1998; 1379:97106.
  • 90
    Pasquini LA, Millet V, Hoyos HC, Giannoni JP, Croci DO, Marder M, Liu FT, Rabinovich GA, Pasquini JM: Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function. Cell Death Differ 2011; 18:17461756.
  • 91
    Sundblad V, Croci DO, Rabinovich GA: Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues. Histol Histopathol 2011; 26:247265.
  • 92
    Markowska AI, Liu FT, Panjwani N: Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med 2010; 207:19811993.
  • 93
    Liu FT, Rabinovich GA: Galectins as modulators of tumour progression. Nat Rev Cancer 2005; 5:2941.
  • 94
    Cao Z, Said N, Amin S, Wu HK, Bruce A, Garate M, Hsu DK, Kuwabara I, Liu FT, Panjwani N: Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem 2002; 277:4229942305.
  • 95
    Yang H, Lei C, Zhang W: Expression of galectin-3 in mouse endometrium and its effect during embryo implantation. Reprod Biomed Online 2012; 24:116122.
  • 96
    Lee VH, Lee AB, Phillips EB, Roberts JK, Weitlauf HM: Spatio-temporal pattern for expression of galectin-3 in the murine utero-placental complex: evidence for differential regulation. Biol Reprod 1998; 58:12771282.
  • 97
    Froehlich R, Hambruch N, Haeger JD, Dilly M, Kaltner H, Gabius HJ, Pfarrer C: Galectin fingerprinting detects differences in expression profiles between bovine endometrium and placentomes as well as early and late gestational stages. Placenta 2012; 33:195201.
  • 98
    Crider-Pirkle S, Billingsley P, Faust C, Hardy DM, Lee V, Weitlauf H: Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. J Biol Chem 2002; 277:1590415912.
  • 99
    Iglesias MM, Rabinovich GA, Ambrosio AL, Castagna LF, Sotomayor CE, Wolfenstein-Todel C: Purification of galectin-3 from ovine placenta: developmentally regulated expression and immunological relevance. Glycobiology 1998; 8:5965.
  • 100
    Troncoso MF, Elola MT, Croci DO, Rabinovich GA: Integrating structure and function of ‘tandem-repeat’ galectins. Front Biosci (Schol Ed) 2012; 4:864887.
  • 101
    Delacour D, Gouyer V, Zanetta JP, Drobecq H, Leteurtre E, Grard G, Moreau-Hannedouche O, Maes E, Pons A, André S, Le Bivic A, Gabius HJ, Manninen A, Simons K, Huet G: Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J Cell Biol 2005; 169:491501.
  • 102
    Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst C, Blumberg RS, Mizoguchi A: Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity 2004; 20:681693.
  • 103
    Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A: Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells. J Exp Med 2012; 209:23832394.
  • 104
    Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi N, Yamashiro C, Hata T, Takegami T, Mogami H, Yamaguchi K, Nakamura T, Otani H, Hatta T, Shoji H: Expression pattern of Galectin 4 in rat placentation. Placenta 2012; 33:885887.
  • 105
    Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR: Structural basis for the recognition of carbohydrates by human galectin-7. Biochemistry 1998; 37:1393013940.
  • 106
    Kuwabara I, Kuwabara Y, Yang RY, Schuler M, Green DR, Zuraw BL, Hsu DK, Liu FT: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem 2002; 277:34873497.
  • 107
    Bidon-Wagner N, Le Pennec JP: Human galectin-8 isoforms and cancer. Glycoconj J 2004; 19:557563.
  • 108
    Zick Y, Eisenstein M, Goren RA, Hadari YR, Levy Y, Ronen D: Role of galectin-8 as a modulator of cell adhesion and cell growth. Glycoconj J 2004; 19:517526.
  • 109
    Nishi N, Shoji H, Seki M, Itoh A, Miyanaka H, Yuube K, Hirashima M, Nakamura T: Galectin-8 modulates neutrophil function via interaction with integrin alphaM. Glycobiology 2003; 13:755763.
  • 110
    Stowell SR, Arthur CM, Dias-Baruffi M, Rodrigues LC, Gourdine JP, Heimburg-Molinaro J, Ju T, Molinaro RJ, Rivera-Marrero C, Xia B, Smith DF, Cummings RD: Innate immune lectins kill bacteria expressing blood group antigen. Nat Med 2010; 16:295301.
  • 111
    Cattaneo V, Tribulatti MV, Campetella O: Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation. Biochem J 2011; 434:153160.
  • 112
    Romaniuk MA, Tribulatti MV, Cattaneo V, Lapponi MJ, Molinas FC, Campetella O, Schattner M: Human platelets express and are activated by galectin-8. Biochem J 2010; 432:535547.
  • 113
    Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernández MM, Malchiodi EL, Frahm I, Croci DO, Compagno D, Rabinovich GA, Wolfenstein-Todel C, Elola MT: Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8. FASEB J 2011; 25:242254.
  • 114
    Kolundžić N, Bojić-Trbojević Z, Radojčić Lj, Petronijević M, Vićovac LJ: Galectin-8 is expressed by villous and extravillous trophoblast of the human placenta. Placenta 2011; 32:909911.
  • 115
    Chabot S, Kashio Y, Seki M, Shirato Y, Nakamura K, Nishi N, Nakamura T, Matsumoto R, Hirashima M: Regulation of galectin-9 expression and release in Jurkat T cell line cells. Glycobiology 2002; 12:111118.
  • 116
    Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005; 6:12451252.
  • 117
    Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA: Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 2007; 318:11411143.
  • 118
    Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hirashima M: Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner. Clin Immunol 2012; 143:5158.
  • 119
    Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD: Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 2005; 123:13071321.
  • 120
    Popovici RM, Krause MS, Germeyer A, Strowitzki T, von Wolff M: Galectin-9: a new endometrial epithelial marker for the mid- and late-secretory and decidual phases in humans. J Clin Endocrinol Metab 2005; 90:61706176.
  • 121
    Heusschen R, Freitag N, Tirado-González I, Barrientos G, Moschansky P, Muñoz-Fernández R, Leno-Durán E, Klapp BF, Thijssen VL, Blois SM: Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological pregnancy. Biol Reprod 2013; 88:22.
  • 122
    Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ, Acharya KR: Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution. Biochemistry 1999; 38:1383713843.
  • 123
    Kubach J, Lutter P, Bopp T, Stoll S, Becker C, Huter E, Richter C, Weingarten P, Warger T, Knop J, Müllner S, Wijdenes J, Schild H, Schmitt E, Jonuleit H: Human CD4+ CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 2007; 110:15501558.
  • 124
    Guardia CM, Gauto DF, Di Lella S, Rabinovich GA, Martí MA, Estrin DA: An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network. J Chem Inf Model 2011; 51:19181930.
  • 125
    Yang RY, Hsu DK, Yu L, Chen HY, Liu FT: Galectin-12 is required for adipogenic signaling and adipocyte differentiation. J Biol Chem 2004; 279:2976129766.
  • 126
    Yang RY, Yu L, Graham JL, Hsu DK, Lloyd KC, Havel PJ, Liu FT: Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci USA 2011; 108:1869618701.
  • 127
    Than NG, Pick E, Bellyei S, Szigeti A, Burger O, Berente Z, Janaky T, Boronkai A, Kliman H, Meiri H, Bohn H, Than GN, Sumegi B: Functional analyses of placental protein 13/galectin-13. Eur J Biochem 2004; 271:10651078.
  • 128
    Balogh A, Pozsgay J, Matkó J, Dong Z, Kim CJ, Várkonyi T, Sammar M, Rigó J Jr, Meiri H, Romero R, Papp Z, Than NG: Placental protein 13 (PP13/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome. Am J Obstet Gynecol 2011; 205:156.e1–156.e14.
  • 129
    Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R: Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Reprod Sci 2012; 19:1630.
  • 130
    Burger O, Pick E, Zwickel J, Klayman M, Meiri H, Slotky R, Mandel S, Rabinovitch L, Paltieli Y, Admon A, Gonen R: Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies. Placenta 2004; 25:608622.
  • 131
    Young AR, Barcham GJ, Kemp JM, Dunphy JL, Nash A, Meeusen EN: Functional characterization of an eosinophil-specific galectin, ovine galectin-14. Glycoconj J 2009; 26:423432.
  • 132
    Lewis SK, Farmer JL, Burghardt RC, Newton GR, Johnson GA, Adelson DL, Bazer FW, Spencer TE: Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment. Biol Reprod 2007; 77:10271036.
  • 133
    Satterfield MC, Bazer FW, Spencer TE: Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus. Biol Reprod 2006; 75:289296.
  • 134
    Gray CA, Adelson DL, Bazer FW, Burghardt RC, Meeusen EN, Spencer TE: Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm. Proc Natl Acad Sci USA 2004; 101:79827987.
  • 135
    Mor G, Cardenas I: The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010; 63:425433.
  • 136
    Liu AX, Jin F, Zhang WW, Zhou TH, Zhou CY, Yao WM, Qian YL, Huang HF: Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. Biol Reprod 2006; 75:414420.
  • 137
    Molvarec A, Blois SM, Stenczer B, Toldi G, Tirado-Gonzalez I, Ito M, Shima T, Yoneda S, Vásárhelyi B, Rigó J Jr, Saito S: Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia. Clin Immunol 2011; 139:4856.
  • 138
    Than NG, Erez O, Wildman DE, Tarca AL, Edwin SS, Abbas A, Hotra J, Kusanovic JP, Gotsch F, Hassan SS, Espinoza J, Papp Z, Romero R: Severe preeclampsia is characterized by increased placental expression of galectin-1. J Matern Fetal Neonatal Med 2008; 21:429442.
  • 139
    Than NG, Kim SS, Abbas A, Han YM, Hotra J, Tarca AL, Erez O, Wildman DE, Kusanovic JP, Pineles B, Montenegro D, Edwin SS, Mazaki-Tovi S, Gotsch F, Espinoza J, Hassan SS, Papp Z, Romero R: Chorioamnionitis and increased galectin-1 expression in PPROM –an anti-inflammatory response in the fetal membranes? Am J Reprod Immunol 2008; 60:298311.
  • 140
    Jeschke U, Mayr D, Schiessl B, Mylonas I, Schulze S, Kuhn C, Friese K, Walzel H: Expression of galectin-1, -3 (gal-1, gal-3) and the Thomsen-Friedenreich (TF) antigen in normal, IUGR, preeclamptic and HELLP placentas. Placenta 2007; 28:11651173.
  • 141
    Odibo AO, Zhong Y, Goetzinger KR, Odibo L, Bick JL, Bower CR, Nelson DM: First-trimester placental protein 13, PAPP-A, uterine artery Doppler and maternal characteristics in the prediction of pre-eclampsia. Placenta 2011; 32:598602.
  • 142
    Cowans NJ, Stamatopoulou A, Khalil A, Spencer K: PP13 as a marker of pre-eclampsia: a two platform comparison study. Placenta 2011; 32:S37S41.