IL-22 Levels are Associated with Trichomonas vaginalis Infection in the Lower Genital Tract
Article first published online: 27 FEB 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 70, Issue 1, pages 38–44, July 2013
How to Cite
IL-22 levels are associated with Trichomonas vaginalis infection in the lower genital tract. Am J Reprod Immunol 2013; 70: 38–44., , , , , , .
- Issue published online: 11 JUN 2013
- Article first published online: 27 FEB 2013
- Manuscript Accepted: 25 JAN 2013
- Manuscript Received: 27 JUL 2012
- NIH. Grant Number: P01 AI082971
- Antimicrobial peptides;
- cervicovaginal lavage;
- genital epithelium;
IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection.
Methods of Study
Women who visited an STD clinic and women from a cohort with frequent Trichomoniasis were studied. IL-22, IL-17, and antimicrobial peptides were measured in cervicovaginal lavage by ELISA.
In women visiting the STD clinic, those without STDs (n = 10) had a median IL-22 of 0 pg/mL, while women with infections (n = 30) had 27 pg/mL (P = 0.04). In the cohort, women with Trichomoniasis (n = 19) had significantly higher IL-22 than women with no infections (n = 21, 74 versus 0 pg/mL, P = 0.0001). IL-17 was also significantly increased in Trichomoniasis, and there was a correlation between IL-22 and IL-17 (P = 0.001).
IL-22 is increased in STDs generally and in Trichomoniasis specifically suggesting an antimicrobial response of the mucosa and an epithelial repair process induced by the STDs.