Which Types of Regulatory T cells Play Important Roles in Implantation and Pregnancy Maintenance?
Article first published online: 23 FEB 2013
© 2013 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Adaptive Immune Responses During Pregnancy
Volume 69, Issue 4, pages 340–345, April 2013
How to Cite
Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?. Am J Reprod Immunol 2013; 69: 340–345, , , .
- Issue published online: 11 MAR 2013
- Article first published online: 23 FEB 2013
- Manuscript Accepted: 25 JAN 2013
- Manuscript Received: 22 JAN 2013
- Extrathymic Treg;
- heterogeneity of Treg;
- memory Treg;
Regulatory T cells (Treg) play essential roles in implantation and allogeneic pregnancy maintenance in mice and humans. Recent data have shown the heterogeneity of Treg, such as thymic (naturally occurring) Treg, extrathymic (inducible or peripheral) Treg, naïve Treg, effector Treg, resting (non-proliferating) Treg and activated (proliferating) Treg. Importantly, Foxp3, which was believed to be a specific marker for Treg, is transiently expressed in T cells when conventional T cells are activated and proliferating in humans showing that Foxp3 is not a specific marker for Treg. Therefore, we should evaluate the true Treg level and clarify which types of Treg cells play important roles in implantation and pregnancy maintenance in mice and humans.