Association between Polymorphisms in the Renin–Angiotensin System Genes and Prevalence of Spontaneously Aborted Fetuses
Article first published online: 11 MAR 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 70, Issue 3, pages 238–245, September 2013
How to Cite
CitationAssociation between polymorphisms in the renin–angiotensin system genes and prevalence of spontaneously aborted fetuses. Am J Reprod Immunol 2013; 70: 238–245, , , , , , , , , , .
- Issue published online: 7 AUG 2013
- Article first published online: 11 MAR 2013
- Manuscript Accepted: 6 FEB 2013
- Manuscript Received: 27 SEP 2012
- Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea. Grant Number: A084923
- renin–angiotensin system;
- spontaneous abortion;
- spontaneously aborted fetuses
The renin–angiotensin system is associated with angiogenesis, tissue remodeling, prenatal development, and Th2 cytokine production. The purpose of this study was to evaluate whether polymorphisms in angiotensin I-converting enzyme [ACE insertion/deletion (I/D)], angiotensinogen (AGT M235T), and angiotensin II type 1 receptor (AT1R 1166A>C) affect the prevalence of spontaneously aborted fetuses (SAFs).
Method of study
One hundred and ninety-eight SAFs were <20 weeks of gestational age. The control subjects were 103 healthy children and 640 adults collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the ACE I/D, AGT M235T, and AT1R 1166A>C genotypes.
II/MM/AA, II/MT/AA, and II/TT/AC of ACE/AGT/AT1R were significantly different from controls. In particular, the statistical significance of the II/MM/AA genotype remained strong in chromosomally normal SAFs.
Our data suggest that the II/MM/AA of ACE/AGT/AT1R is a possible predisposing factor for spontaneous abortion.