AS and ACZ share senior authorship.
HO-1 As Modulator of the Innate Immune Response in Pregnancy
Article first published online: 22 MAR 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 70, Issue 1, pages 24–30, July 2013
How to Cite
HO-1 as modulator of the innate immune response in pregnancy. Am J Reprod Immunol 2013; 70: 24–30., , , , , , .
- Issue published online: 11 JUN 2013
- Article first published online: 22 MAR 2013
- Manuscript Accepted: 21 FEB 2013
- Manuscript Received: 10 JAN 2013
- DFG. Grant Number: ZE 526/5-1
- Medical Faculty of the Otto-von-Guericke University of Magdeburg
The immune modulatory effect of heme oxygenase-1 (HO-1) is well documented in studies about sepsis and transplantation. This work evaluates the influence of HO-1 on the innate immune response during pregnancy.
Method of Study
Human first-trimester trophoblasts derived from normal pregnancies or spontaneous abortions were analyzed for their basal HO-1, BCL-associated athanogene-1 (Bag-1), and cytokine production before and after LPS treatment. In vivo, pregnant Hmox1+/+ and Hmox1+/− female mice were treated with LPS, and the production of Bag-1 was evaluated.
Human trophoblasts up-regulated the expression of both HO-1 and pro-inflammatory cytokines after LPS treatment, whereas the basal level of HO-1 was higher in normal pregnancies. In vivo, HO-1 deficiency provoked diminished Bag-1 level upon LPS treatment.
HO-1 deficiency causes an inflammatory immune reaction and diminished expression of protective molecules in trophoblasts. Thus, HO-1 emerges as one important modulator of innate immune responses in pregnancy.