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An Immunological Basis for Chronic Histiocytic Intervillositis in Recurrent Fetal Loss

Authors

  • Averil D. Reus,

    Corresponding author
    1. Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    • Correspondence

      Averil D. Reus, Department Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, Room He-111, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

      E-mail: a.reus@erasmusmc.nl

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  • Nicole M. van Besouw,

    1. Department of Internal Medicine-Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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  • Nikki M. Molenaar,

    1. Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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  • Eric A.P. Steegers,

    1. Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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  • Willy Visser,

    1. Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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  • Ronella P. de Kuiper,

    1. Department of Internal Medicine-Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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  • Ronald R. de Krijger,

    1. Department of Pathology, Reinier de Graaf Hospital, Delft, The Netherlands
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  • Dave L. Roelen,

    1. Department of Immunohaematology and Blood Transfusion, Leids University Medical Center, Leiden, The Netherlands
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  • Niek Exalto

    1. Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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Abstract

Problem

Chronic histiocytic intervillositis (CHIV) is a rare type of placental pathology that is associated with reproductive loss at all gestational ages. The aim of the study was to investigate the relationship between the severity of CHIV and the outcome of pregnancy and to compare the immune response between CHIV patients and controls to explore an immunological origin of CHIV.

Method of study

Microscopic slides were reviewed and scored according to a previously published grading system in 30 pregnancies of 22 CHIV patients. Partner-specific mixed lymphocyte reactions, cytotoxic T-lymphocyte precursor frequencies (CTLpf), and anti-HLA antibodies were determined in four patients and seven controls.

Results

Higher CHIV scores are associated with worse pregnancy outcome. CHIV patients demonstrated a higher CTLpf against their partner compared to non-complicated pregnancies (P = 0.03). The CTLpf was extremely high in 75% of the patients. Antipaternal HLA antibodies were only present in 75% of the CHIV patients compared to none of the controls (= 0.02).

Conclusion

CHIV scores seem to be associated with the severity of adverse pregnancy outcome. High antipaternal cellular (T-cell) and humoral (B-cell) response to partner-specific CTLpf and the presence of anti-HLA antibodies directed to the partner suggest an immunologic origin of CHIV.

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