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Keywords:

  • Cervical infection;
  • human papillomavirus;
  • recurrent miscarriage

Problem

To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM).

Methods

In this retrospective case–control study, 49 women with unexplained RM (Group 1 – cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 – controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR).

Results

HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P < 0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30–39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings.

Conclusion

Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.