Recurrent Miscarriage and Cervical Human Papillomavirus Infection
Article first published online: 16 SEP 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 70, Issue 5, pages 343–346, November 2013
How to Cite
Recurrent miscarriage and cervical human papillomavirus infection. Am J Reprod Immunol 2013; 70: 343–346, , , , , .
- Issue published online: 9 OCT 2013
- Article first published online: 16 SEP 2013
- Manuscript Accepted: 16 AUG 2013
- Manuscript Received: 15 JUN 2013
- Cervical infection;
- human papillomavirus;
- recurrent miscarriage
To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM).
In this retrospective case–control study, 49 women with unexplained RM (Group 1 – cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 – controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR).
HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P < 0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30–39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings.
Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.