FJ and ACZ share senior authorship.
Cutting Edge: IL-10-Producing Regulatory B Cells in Early Human Pregnancy
Article first published online: 10 OCT 2013
© 2013 John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 70, Issue 6, pages 448–453, December 2013
How to Cite
Cutting Edge: IL-10-producing regulatory B cells in early human pregnancy. Am J Reprod Immunol 2013; 70: 448–453, , , , , , , , .
- Issue published online: 14 NOV 2013
- Article first published online: 10 OCT 2013
- Manuscript Accepted: 16 AUG 2013
- Manuscript Received: 14 JUN 2013
- Deutsche Forschungsgemeinschaft. Grant Number: ZE 526/7-1
- Fritz Thyssen Foundation
- University Pompeu Fabra
- hCG ;
The function of IL-10 producing regulatory B cells (Breg) during gestation is unknown. Here, we aimed to understand their participation in early pregnancy.
CD19+CD24hiCD27+B cell frequency, measured by flow cytometry, increased with pregnancy onset but not in the case of spontaneous abortions.
B cells from non-pregnant women cultured with serum from normal pregnant women produced higher IL-10 levels than those cultured with serum from spontaneous abortion patients or autologous serum. CD19+-activated B cells from pregnant women strongly suppressed TNF-a production by CD4+T cells when cocultured. We identified hCG as an important factor regulating the number and function of Breg during pregnancy.
Breg emerge as important players in pregnancy; they suppress undesired immune responses from maternal T cells and are therefore important for tolerance acquisition.