Get access

The Role of Serpin and Cystatin Antiproteases in Mucosal Innate Immunity and their Defense against HIV

Authors

  • Lindsay Aboud,

    1. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Search for more papers by this author
  • Terry Blake Ball,

    1. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    2. Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    3. National HIV and Retrovirology laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Search for more papers by this author
  • Annelie Tjernlund,

    1. Department Medicine, Karolinska Institute, Solna, Sweden
    Search for more papers by this author
  • Adam Burgener

    Corresponding author
    1. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    2. National HIV and Retrovirology laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    • Correspondence

      Adam Burgener, Department of Medical Microbiology, University of Manitoba, 507-745 Bannatyne Ave. Basic Medical Sciences Building, Winnipeg, Manitoba R3E 0W3, Canada. E-mail: burgener@cc.umanitoba.ca

    Search for more papers by this author

Abstract

Antiproteases play diverse roles in nature, from regulating protease activity to innate defense against microorganisms. Recently, antiproteases have been shown to play important roles in HIV pathogenesis including, inhibiting HIV binding and replication and reducing activation and inflammation of susceptible cells. They have also been implicated as one of the initial host responders, in plasma, to control replication of HIV. More recently, antiproteases expressed at the mucosal surface have been linked to reduced susceptibility to HIV infection in HIV-exposed sero-negative individuals. These factors are expressed in the epithelial layer of the female genital tract, thus at the frontline of defense against mucosal infection. This review focuses on the specific antimicrobial roles of antiproteases, focusing on serpins and cystatins, with an emphasis on their known and potential roles in HIV infection. Their potential as therapeutic interventions to combat HIV is also discussed.

Ancillary