Polymorphisms in Inflammatory Genes are Associated with Term Small for Gestational Age and Preeclampsia
Article first published online: 4 APR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 71, Issue 5, pages 472–484, May 2014
How to Cite
Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia. Am J Reprod Immunol 2014; 71: 472–484, , , , , , , .
- Issue published online: 16 APR 2014
- Article first published online: 4 APR 2014
- Manuscript Accepted: 26 FEB 2014
- Manuscript Received: 23 DEC 2013
- NICHD. Grant Number: R21 HD060207
- NIEHS. Grant Number: 2-T32-ES07018
- NIEHS. Grant Number: P30ES010126
- Mount Sinai Center for Children's Environmental Health
- NIH. Grant Numbers: HD28684, HD28684A, HD37584, HD39373, RR00046
- African Americans;
- genetic association studies;
- small for gestational age
Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.
Method of study
Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.
Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% CI 1.1–2.7).
Although previous studies have suggested null associations, increased tagging and stratification by genetic ancestry suggests important associations between IL6 and term SGA for African Americans, and a TNF regulator and PE among European Americans (N = 149).