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New Insights into the Relationship between Viral Infection and Pregnancy Complications

Authors

  • Ja-Young Kwon,

    1. Reproductive Immunology Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    2. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, South Korea
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  • Roberto Romero,

    1. Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Detroit, MI, USA
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  • Gil Mor

    Corresponding author
    1. Reproductive Immunology Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    • Correspondence

      Gil Mor, Reproductive Immunology Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street LSOG 305A, New Haven, CT 06520, USA.

      E-mail: gil.mor@yale.edu

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Abstract

A recent study by McDonnold and coinvestigators published in Am J Obstet Gynecol reports an association between human papillomavirus (HPV) infection and preeclampsia. The investigation was based on the hypothesis that HPV trophoblast infection results in failed trophoblast invasion, and placental dysfunction and hypoxia. The findings from this study along with previous data addressing the relationship between viral infection and obstetrical complications highlight the relevance of viral infection during pregnancy. A better understanding of mechanisms via which virus leads to pregnancy complications will drive us closer to finding a strategy to prevent adverse outcomes.

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