The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention (CDC).
Non-Human Primate Models of Hormonal Contraception and HIV
Version of Record online: 10 APR 2014
© Published 2014. This article is a U.S. Government work and is in the public domain in the USA
American Journal of Reproductive Immunology
Special Issue: Sex Hormones and HIV Transmission
Volume 71, Issue 6, pages 513–522, June 2014
How to Cite
Non-human primate models of hormonal contraception and HIV. Am J Reprod Immunol 2014; 71: 513–522, , , .
A part of this work was previously presented at the Symposium on Hormone Regulation of the Mucosal Environment in the Reproductive Tract and the Prevention of HIV infection, May 2013, Boston, USA, a satellite symposium of the International Society for Immunology of Reproduction/American Society for Reproductive Immunology meeting, June 2013.
- Issue online: 16 MAY 2014
- Version of Record online: 10 APR 2014
- Manuscript Accepted: 3 MAR 2014
- Manuscript Received: 4 FEB 2014
- CDC. Grant Number: AAI 12041
- Acquisition risk;
- simian immunodeficiency viruses (SIV);
- SIVs expressing HIV genes
Recent concerns that hormonal contraception (HC) may increase risk of HIV acquisition has led to keen interest in using non-human primates (NHP) to understand the underlying mechanism and the magnitude of the risk. This is, in part, because some experiments which would be difficult or logistically impossible in women are more easily conducted in NHP.
Method of study
NHP models of HIV can inform HIV acquisition and pathogenesis research and identify and evaluate biomedical preventions and treatments for HIV/AIDS. Widely used species include rhesus, pigtail, and cynomolgous macaques.
This paper reviews past, current and proposed NHP research around the intersection of HIV and HC.
NHP research may lead to the identification of hormonally regulated biomarkers that correlate with HIV-acquisition risk, to a ranking of existing or next-generation HC along an HIV-acquisition risk profile, and inform research around new biomedical preventions for HIV.