Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and Transcobalamin II Receptor (TCblR 1104C>T) Polymorphisms in Korean Patients with Idiopathic Recurrent Spontaneous Abortion
Article first published online: 18 APR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
American Journal of Reproductive Immunology
Volume 72, Issue 3, pages 337–346, September 2014
How to Cite
Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion. Am J Reprod Immunol 2014; 72: 337–346, , , , , , , .
- Issue published online: 7 AUG 2014
- Article first published online: 18 APR 2014
- Manuscript Accepted: 18 MAR 2014
- Manuscript Received: 29 NOV 2013
- National Research Foundation
- Ministry of Education. Grant Numbers: 2009-0093821, NRF-2012R1A1A2007033
- Korea Healthcare technology R&D Project
- Ministry for Health, Welfare & Family Affairs, South Korea. Grant Number: A120080
- recurrent spontaneous abortion;
- transcobalamin II;
- transcobalamin II receptor
The transcobalamin II (TCN2) 776C>G polymorphism has been reported to be a genetic risk factor for idiopathic recurrent spontaneous abortion (RSA). However, the sample size in previous studies was small, and other TCN2 polymorphisms have not been studied. Moreover, the TCN2 67A>G and 776C>G polymorphisms, and the transcobalamin II receptor (TCblR/CD320) 1104C>T polymorphism, have demonstrated associations with immune responses.
Method of study
Three hundred and seventy-eight RSA patients who had at least two consecutive spontaneous abortions were enrolled. Two hundred and seven control subjects were collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the TCN2 67A>G and 776C>G polymorphisms, and the TCblR 1104C>T polymorphism.
RSA patients showed significantly different frequencies of the TCN2 67AG+GG genotypes compared with control subjects.
The TCN2 67G allele is a possible risk factor for idiopathic RSA.