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Keywords:

  • Polymorphism;
  • recurrent spontaneous abortion;
  • TCblR;
  • TCN2;
  • transcobalamin II;
  • transcobalamin II receptor

Problem

The transcobalamin II (TCN2) 776C>G polymorphism has been reported to be a genetic risk factor for idiopathic recurrent spontaneous abortion (RSA). However, the sample size in previous studies was small, and other TCN2 polymorphisms have not been studied. Moreover, the TCN2 67A>G and 776C>G polymorphisms, and the transcobalamin II receptor (TCblR/CD320) 1104C>T polymorphism, have demonstrated associations with immune responses.

Method of study

Three hundred and seventy-eight RSA patients who had at least two consecutive spontaneous abortions were enrolled. Two hundred and seven control subjects were collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the TCN2 67A>G and 776C>G polymorphisms, and the TCblR 1104C>T polymorphism.

Results

RSA patients showed significantly different frequencies of the TCN2 67AG+GG genotypes compared with control subjects.

Conclusion

The TCN2 67G allele is a possible risk factor for idiopathic RSA.