Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies
Article first published online: 28 MAY 2014
© 2014 The Authors. American Journal of Reproductive Immunology Published by John Wiley & Sons Ltd.
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American Journal of Reproductive Immunology
Volume 72, Issue 4, pages 422–434, October 2014
How to Cite
Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies. Am J Reprod Immunol 2014; 72: 422–434, , , , , , .
- Issue published online: 9 SEP 2014
- Article first published online: 28 MAY 2014
- Manuscript Accepted: 29 APR 2014
- Manuscript Received: 9 APR 2014
- Canadian Institute for Health Research Fellowship (SG)
- Tommy's – the baby charity
- NIHR Manchester Wellcome Trust Clinical Research Facility
- NIHR Greater Manchester Clinical Local Research Network
- Manchester Biomedical Research Centre
- High-risk pregnancy;
- placental dysfunction;
Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.
Method of study
The inflammatory profile of villous tissue was studied in pregnancies at high-risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).
Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)-1 receptor antagonist and decreased IL-10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell-free fetal DNA).
This distinct inflammatory profile at the maternal-fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.