• 1
    Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 11241136.
  • 2
    Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic “preconditioning” protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 1993; 87: 893899.
  • 3
    Hale SL, Bellows SD, Hammerman H, Kloner RA. An adenosine A1 receptor agonist, R(-)-N-(2-phenylisopropyl)-adenosine (PIA), but not adenosine itself, acts as a therapeutic preconditioning-mimetic agent in rabbits. Cardiovasc Res 1993; 27: 21402145.
  • 4
    Birnbaum Y, Hale SL, Kloner RA. Ischemic preconditioning at a distance: Reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit. Circulation 1997; 96: 16411646.
  • 5
    Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: underlying mechanisms and clinical application. Atherosclerosis 2009; 204: 334341.
  • 6
    Tekin D, Dursun AD, Xi L. Hypoxia inducible factor 1 (HIF-1) and cardioprotection. Nature Pub Group 2010; 31: 10851094.
  • 7
    Landymore RW, Bayes AJ, Murphy JT, Fris JH. Preconditioning prevents myocardial stunning after cardiac transplantation. Ann Thorac Surg 1998; 66: 19531957.
  • 8
    Konstantinov IE, Li J, Cheung MM, Shimizu M, Stokoe J, Kharbanda RK, Redington AN. Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism. Transplantation 2005; 79: 16911695.
  • 9
    Kirsch M, Farhat F, Garnier JP, Loisance D. Acute brain death abolishes the cardioprotective effects of ischemic preconditioning in the rabbit. Transplantation 2000; 69: 20132019.
  • 10
    Li YW, Whittaker P, Kloner RA. The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia. Am Heart J 1992; 123: 346353.
  • 11
    Luca MC, Liuni A, Muxel S, Münzel T, Forconi S, Gori T, Parker JD. Chronic pharmacological preconditioning against ischemia. Clin. Hemorheol. Microcirc 2011; 49: 287293.
  • 12
    Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001; 292: 468472.
  • 13
    Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 2008; 134: 145155.
  • 14
    Koskinen PK, Lemström KB, Häyry PJ. How cyclosporine modifies histological and molecular events in the vascular wall during chronic rejection of rat cardiac allografts. Am J Pathol 1995; 146: 972980.
  • 15
    Eckle T, Hartmann K, Bonney S, et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 2012; 18: 774782.
  • 16
    Keränen MAI, Nykänen AI, Krebs R, Pajusola K, Tuuminen R, Alitalo K, Lemström KB. Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat. J Heart Lung Transplant 2010; 29: 10581066.
  • 17
    Rosenberger C, Mandriota S, Jürgensen JS, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002; 13: 17211732.
  • 18
    Weis S, Shintani S, Weber A, et al. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J Clin Invest 2004; 113: 885894.
  • 19
    Tsurumi Y, Murohara T, Krasinski K, et al. Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med 1997; 3: 879886.
  • 20
    Bach FH, Hancock WW, Ferran C. Protective genes expressed in endothelial cells: A regulatory response to injury. Immunol Today 1997; 18: 483486.
  • 21
    Loor G, Schumacker P. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differentiation 2008; 15: 686690.
  • 22
    Fraisl P, Aragonés J, Carmeliet P. Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 2009; 8: 139152.
  • 23
    Feinman R, Deitch EA, Watkins AC, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2010; 299: G833G843.
  • 24
    Kannan KB, Colorado I, Reino D, et al. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2011; 300: G853G861.
  • 25
    Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57: 10091014.
  • 26
    Bakker WJ, Harris IS, Mak TW. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell 2007; 28: 941953.
  • 27
    Dehne N, Brüne B. HIF-1 in the inflammatory microenvironment. Exp Cell Res 2009; 315: 17911797.
  • 28
    Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med 2011; 364: 656665.
  • 29
    Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721732.
  • 30
    Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern MD, Horowitz M. HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiol Genomics 2005; 23: 7988.
  • 31
    Bigaud M, Gfeller P, Deveze S, et al. Transplantation-induced ischemia/reperfusion injury in the rat heart. Transplant Proc 1998; 30: 23112313.
  • 32
    Lee PJ, Jiang BH, Chin BY, et al. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 1997; 272: 53755381.
  • 33
    Whitlock NA, Agarwal N, Ma J-X, Crosson CE. Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats. Invest Ophthalmol Vis Sci 2005; 46: 10921098.
  • 34
    Xi L, Taher M, Yin C, Salloum F, Kukreja RC. Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling. Am J Physiol Heart Circ Physiol 2004; 287: H2369H2375.
  • 35
    Ockaili R, Natarajan R, Salloum F, et al. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol 2005; 289: H542H548.
  • 36
    Raphael J, Zuo Z, Abedat S, Beeri R, Gozal Y. Isoflurane preconditioning decreases myocardial infarction in rabbits via up-regulation of hypoxia inducible factor 1 that is mediated by mammalian target of rapamycin. Anesthesiology 2008; 108: 415425.
  • 37
    Bao W, Qin P, Needle S, et al. Chronic inhibition of hypoxia-inducible factor (HIF) prolyl 4-hydroxylase improves ventricular performance, remodeling and vascularity following myocardial infarction in the rat. J Cardiovasc Pharmacol 2010.
  • 38
    Bernhardt WM, Gottmann U, Doyon F, et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci USA 2009; 106: 2127621281.
  • 39
    Taylor DO, Stehlik J, Edwards LB, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. J Heart Lung Transplant 2009; 28: 10071022.
  • 40
    Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: Risk factors and implications for renal allograft survival. Transplantation 1997; 63: 968974.
  • 41
    Rosenberger C, Heyman SN, Rosen S, et al. Up-regulation of HIF in experimental acute renal failure: Evidence for a protective transcriptional response to hypoxia. Kidney Int 2005; 67: 531542.
  • 42
    Jürgensen JS, Rosenberger C, Wiesener MS, et al. Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J 2004; 18: 14151417.
  • 43
    Diwan V, Jaggi AS, Singh M, Singh N, Singh D. Possible involvement of erythropoietin in remote renal preconditioning-induced cardioprotection in rats. J Cardiovasc Pharmacol 2008; 51: 126130.
  • 44
    Eckle T, Kohler D, Lehmann R, Kasmi KE, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning. Circulation 2008; 118: 166175.
  • 45
    Tang WH, Wu S, Wong TM, Chung SK,Chung SSM. Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart. Free Radic Biol Med 2008; 45: 602610.
  • 46
    Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 2008; 111: 32363244.
  • 47
    Lei L, Mason S, Liu D, Huang Y, et al. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol 2008; 28: 37903803.
  • 48
    Aharinejad S, Schäfer R, Krenn K, et al. Donor myocardial HIF-1alpha is an independent predictor of cardiac allograft dysfunction: A 7-year prospective, exploratory study. Am J Transplant 2007; 7: 20122019.
  • 49
    Rosenberger C, Pratschke J, Rudolph B, et al. Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies. J Am Soc Nephrol 2007; 18: 343351.
  • 50
    Nallamothu B, Fox KAA, Kennelly BM, et al. GRACE Investigators. Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. The Global Registry of Acute Coronary Events. Heart 2007; 93: 15521555.
  • 51
    Armstrong PW, Westerhout CM, Welsh RC. Duration of symptoms is the key modulator of the choice of reperfusion for ST-elevation myocardial infarction. Circulation 2009; 119: 12931303.
  • 52
    Eltzschig HK, Eckle T. Ischemia and reperfusion—from mechanism to translation. Nat Med 2011; 17: 13911401.
  • 53
    Krüger B, Krick S, Dhillon N, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci USA 2009; 106: 33903395.
  • 54
    El-Sawy T, Miura M, Fairchild R. Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am J Pathol 2004; 165: 147157.