Authors contributed equally.
The Higher Diabetogenic Risk of Tacrolimus Depends on Pre-Existing Insulin Resistance. A Study in Obese and Lean Zucker Rats
Version of Record online: 7 MAY 2013
© Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 13, Issue 7, pages 1665–1675, July 2013
How to Cite
Rodriguez-Rodriguez, A. E., Triñanes, J., Velazquez-Garcia, S., Porrini, E., Vega Prieto, M. J., Diez Fuentes, M. L., Arevalo, M., Salido Ruiz, E. and Torres, A. (2013), The Higher Diabetogenic Risk of Tacrolimus Depends on Pre-Existing Insulin Resistance. A Study in Obese and Lean Zucker Rats. American Journal of Transplantation, 13: 1665–1675. doi: 10.1111/ajt.12236
- Issue online: 26 JUN 2013
- Version of Record online: 7 MAY 2013
- Manuscript Accepted: 28 FEB 2013
- Manuscript Revised: 22 FEB 2013
- Manuscript Received: 31 OCT 2012
- Instituto de Salud Carlos III. Grant Number: PI 07/0732
- REDINREN. Grant Numbers: RD/0021/0008, PI10/02428
- IRSIN and Fondos FEDER
Additional supporting information may be found in the online version of this article at the publisher's web-site.
Figure S1: Plasma levels of FK506 and CsA after 11 days of treatment in Obese Zucker Rats (OZR) (A) and Lean Zucker Rats (LZR) (B).
Figure S2: Islets morphometry in Obese Zucker rats after withdrawal of CNI for 5 days (n = 10 per treatment). (A) Islet area adjusted for total pancreas area. FK versus PBS p = 0.108; FK versus CsA p = 0.228; and CsA versus PBS p = 0.608. (B) Number of islets per mm2 of total pancreas. *FK versus PBS p = 0.010, FK versus CsA p = 0.202 and CsA versus PBS p = 0.293. Columns represent mean values ± SD.
Table S1: Biochemical and intraperitoneal glucose tolerance tests results at Day 12 in the lean Zucker rats (LZR).
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