Both authors contributed equally.
Persistence of Yellow Fever Vaccine–Induced Antibodies After Solid Organ Transplantation
Article first published online: 4 SEP 2013
© Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 13, Issue 9, pages 2458–2461, September 2013
How to Cite
Wyplosz, B., Burdet, C., François, H., Durrbach, A., Duclos-Vallée, J. C., Mamzer-Bruneel, M.-F., Poujol, P., Launay, O., Samuel, D., Vittecoq, D., Consigny, P. H. and for the GEVACCIM (2013), Persistence of Yellow Fever Vaccine–Induced Antibodies After Solid Organ Transplantation. American Journal of Transplantation, 13: 2458–2461. doi: 10.1111/ajt.12338
GEVACCIM (groupe d'étude de la vaccination des immunodéprimés): Launay O, Ancelle T, Calmus Y, Consigny PH, Duchet–Niedziolka P, Hanslik T, Kerneis S, Lortholary O, Loulergue P, Mazmer MF, D, Vittecoq D, Wyplosz B.
- Issue published online: 4 SEP 2013
- Article first published online: 4 SEP 2013
- Manuscript Accepted: 13 MAY 2013
- Manuscript Revised: 6 MAY 2013
- Manuscript Received: 20 MAR 2013
- Antibody persistence;
- solid organ transplantation;
- yellow-fever vaccine
Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40–80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2–32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation.