Immune Cell-Derived C3a and C5a Costimulate Human T Cell Alloimmunity
Article first published online: 6 SEP 2013
© Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 13, Issue 10, pages 2530–2539, October 2013
How to Cite
Cravedi, P., Leventhal, J., Lakhani, P., Ward, S. C., Donovan, M. J. and Heeger, P. S. (2013), Immune Cell-Derived C3a and C5a Costimulate Human T Cell Alloimmunity. American Journal of Transplantation, 13: 2530–2539. doi: 10.1111/ajt.12405
- Issue published online: 24 SEP 2013
- Article first published online: 6 SEP 2013
- Manuscript Accepted: 27 JUN 2013
- Manuscript Revised: 24 JUN 2013
- Manuscript Received: 3 JUN 2013
Additional Supporting Information may be found in the online version of this article.
|ajt12405-sm-001-SuppFig-S1.jpg||309K||Figure S1: (A) Representative flow plots of CD40, CD80, CD86, HLA-DR, in C3kd and control moDCs after 3 days of LPS stimulation. No difference was found between groups in three separate experiments.|
|ajt12405-sm-001-SuppFig-S2.jpg||1807K||Figure S2: (A) Representative photomicographs of H&E–stained liver tissue from NOD scid γcnull mice at 4 weeks after human PBMC injection (20 × 106). Arrow identifies mononuclear cells. (B) Representative IF photomicrograph documenting the presence of human CD4 (yellow) and CD8 (green) T cells infiltrating mouse liver on d 40 after adoptive transfer of human PBMCs. CD4+CD25+FOXP3+ T cells before and at 40 days after injection in NOD Scid γ2 mice.|
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