An Anti-CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA-4 Ig
Version of Record online: 5 SEP 2013
© Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 13, Issue 11, pages 3021–3030, November 2013
How to Cite
Pinelli, D. F., Wagener, M. E., Liu, D., Yamniuk, A., Tamura, J., Grant, S., Larsen, C. P., Suri, A., Nadler, S. G. and Ford, M. L. (2013), An Anti-CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA-4 Ig. American Journal of Transplantation, 13: 3021–3030. doi: 10.1111/ajt.12417
- Issue online: 28 OCT 2013
- Version of Record online: 5 SEP 2013
- Manuscript Accepted: 1 JUL 2013
- Manuscript Revised: 14 JUN 2013
- Manuscript Received: 30 APR 2013
- National Institutes of Health. Grant Number: R01 AI073707
Additional Supporting Information may be found in the online version of this article.
|ajt12417-sup-0001-SuppFig-S1.pdf||478K||Figure S1: Fc-modified anti-CD154 dAb is deficient in Fc receptor binding. (A and B) Binding of antibodies to immobilized Fc receptors was measured by surface plasmon resonance. Antibodies were injected through flow cells containing the indicated immobilized murine Fc receptors. A 97 kDa positive control protein fused to a wild-type mIgG2A Fc domain demonstrates efficient binding to his-tagged mCD64, mCD32b, mCD16, and mCD16-2, captured on an anti-his Fab surface (A), whereas no Fc receptor binding is observed for the Fc-modified anti-CD154 dAb (B).|
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