De Novo Sirolimus and Reduced-Dose Tacrolimus Versus Standard-Dose Tacrolimus After Liver Transplantation: The 2000–2003 Phase II Prospective Randomized Trial
Article first published online: 23 JAN 2014
© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 14, Issue 2, pages 356–366, February 2014
How to Cite
Asrani, S. K., Wiesner, R. H., Trotter, J. F., Klintmalm, G., Katz, E., Maller, E., Roberts, J., Kneteman, N., Teperman, L., Fung, J. J. and Millis, J. M. (2014), De Novo Sirolimus and Reduced-Dose Tacrolimus Versus Standard-Dose Tacrolimus After Liver Transplantation: The 2000–2003 Phase II Prospective Randomized Trial. American Journal of Transplantation, 14: 356–366. doi: 10.1111/ajt.12543
- Issue published online: 28 JAN 2014
- Article first published online: 23 JAN 2014
- Manuscript Revised: 20 SEP 2013
- Manuscript Accepted: 20 SEP 2013
- Manuscript Received: 22 MAY 2013
Additional Supporting Information may be found in the online version of this article.
Figure S1: Incidence acute rejection in patients randomized to standard-dose tacrolimus (TAC) or sirolimus and reduced-dose tacrolimus arm (SRL). Closed circle: Sirolimus and reduced-dose tacrolimus. Open circle: Standard-dose tacrolimus.
Figure S2: Tacrolimus dose and trough levels in patients assigned to the standard-dose tacrolimus arm (mean ± standard error).
Figure S3: Sirolimus and tacrolimus dose and trough levels (mean ± standard error) in patients assigned to the sirolimus and reduced-dose tacrolimus arm.
Table S1: Causes of death and graft loss.
Table S2: Renal function as measured by creatinine clearance (mL/min) in standard-dose tacrolimus arm and sirolimus and reduced-dose tacrolimus arm.
Table S3: Drug levels in subjects assigned to the sirolimus and reduced-dose tacrolimus arm.
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