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Figure S1: Incidence acute rejection in patients randomized to standard-dose tacrolimus (TAC) or sirolimus and reduced-dose tacrolimus arm (SRL). Closed circle: Sirolimus and reduced-dose tacrolimus. Open circle: Standard-dose tacrolimus.

Figure S2: Tacrolimus dose and trough levels in patients assigned to the standard-dose tacrolimus arm (mean ± standard error).

Figure S3: Sirolimus and tacrolimus dose and trough levels (mean ± standard error) in patients assigned to the sirolimus and reduced-dose tacrolimus arm.

Table S1: Causes of death and graft loss.

Table S2: Renal function as measured by creatinine clearance (mL/min) in standard-dose tacrolimus arm and sirolimus and reduced-dose tacrolimus arm.

Table S3: Drug levels in subjects assigned to the sirolimus and reduced-dose tacrolimus arm.

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