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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
ajt12742-sm-0001-SuppFig-S1.tiff4732KFigure S1: Protein-releasing scaffolds alone do not restore euglycemia. Blood glucose was measured over time from mice transplanted without islets with a 3% Ex4, 6% IGF-1 or blank scaffold (n = 3 each).
ajt12742-sm-0001-SuppFig-S2.tif4331KFigure S2: Removal of grafts induces hyperglycemia. Diabetic mice implanted with insulin pellets on Day −5 were transplanted with human islets on 3% Ex4 scaffolds (n = 3). Insulin pellets were removed on the day of transplant. Grafts were removed on Day 15, resulting in a return to hyperglycemia.
ajt12742-sm-0001-SuppFig-S3.tiff743KFigure S3: Histological analysis of islets. At Day 30 posttransplant, grafts from 3% Ex4 scaffold (A) and blank scaffold (B) mice do not show significant fibrosis between the transplanted islets and the host epididymal fat.

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