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American Journal of Transplantation

Cover image for Vol. 6 Issue 10

October 2006

Volume 6, Issue 10

Pages 2225–2525

  1. Editorials

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Original Articles:
    5. Brief Communications
    6. Case Reports
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      It Is Time to Re-Think ‘Extended Criteria’ (pages 2225–2227)

      R. B. Freeman and G. B. Klintmalm

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01506.x

      We must stop conceptualizing and presenting donors as either “good” and “bad”: simplistic dual variables ignore the reality of the donor pool.

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      Of Ends and Means (pages 2228–2229)

      A. D. Kirk and J. A. Light

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01500.x

      The combination of severe depletion with alemtuzumab followed by later immunosuppressive drug weaning raises many concerns that need to be assessed in an objective, controlled, IRB-approved approach. See also article by Tan et al in this issue on page 2409.

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      The Sensitized Recipient: What is to be Done? (pages 2230–2231)

      B. Hippen

      Version of Record online: 4 SEP 2006 | DOI: 10.1111/j.1600-6143.2006.01525.x

      The evaluation and implementation of new protocols for transplanting highly-sensitized patients should be a high priority to reduce the morbidity and mortality faced by these people on the transplant waiting list. See also article by Bray et al in this issue on page 2307.

  2. Minireviews

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Original Articles:
    5. Brief Communications
    6. Case Reports
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      Emerging Issues in Hepatitis C Virus-Positive Liver and Kidney Transplant Recipients (pages 2232–2237)

      R. D. Bloom and J. R. Lake

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01457.x

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      A surprising issue that has recently emerged from studies of liver transplantation in Hepatitis C infected liver and kidney transplant patients is the heightened risk for new onset diabetes in such individuals, raising intriguing questions about the mechanisms and implications of this association.

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      Composite Tissue Allograft Extends a Helping Hand to Transplant Immunologists (pages 2238–2242)

      O. Thaunat, L. Badet, A. El-Jaafari, J. Kanitakis, J.-M. Dubernard and E. Morelon

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01486.x

      Experience with hand and other composite tissue transplants offers many insights for the transplant immunologist, such as the decreased immunogenicity of skin, the differential survival of various tissue components, and the effects of transplanting bone marrow.

  3. Original Articles:

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Original Articles:
    5. Brief Communications
    6. Case Reports
    1. Basic Science

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      Ex Vivo Application of Carbon Monoxide in University of Wisconsin Solution to Prevent Intestinal Cold Ischemia/Reperfusion Injury (pages 2243–2255)

      A. Nakao, H. Toyokawa, A. Tsung, M. A. Nalesnik, D. B. Stolz, J. Kohmoto, A. Ikeda, K. Tomiyama, T. Harada, T. Takahashi, R. Yang, M. P. Fink, K. Morita, A. M. K. Choi and N. Murase

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01465.x

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      Rat small bowel preserved in solution that incorporated carbon monoxide manifested better survival when transplanted, and better initial function, suggesting a simple strategy to improve intestinal preservation fluids for transplantation.

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      Increasing Resistance of Tubular Epithelial Cells to Apoptosis by shRNA Therapy Ameliorates Renal Ischemia-Reperfusion Injury (pages 2256–2267)

      C. Du, S. Wang, H. Diao, Q. Guan, R. Zhong and A. M. Jevnikar

      Version of Record online: 7 SEP 2006 | DOI: 10.1111/j.1600-6143.2006.01478.x

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      Rat small bowel preserved in solution that incorporated carbon monoxide manifested better survival when transplanted, and better initial function, suggesting a simple strategy to improve intestinal preservation fluids for transplantation.

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      Activation and Maturation of Alloreactive CD4-Independent, CD8+ Cytolytic T Cells (pages 2268–2281)

      K. E. Lunsford, P. H. Horne, M. A. Koester, A. M. Eiring, J. P. Walker, H. L. Dziema and G. L. Bumgardner

      Version of Record online: 4 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01479.x

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      Comparison of two cell transplant models (hepatocellular and islet allografts) indicates differential ability of these tissues to induce CD8+ cytotoxic T cells, suggesting a role for tissue-derived factors in this pathway of CD4- independent CD8 T cell activation and maturation.

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      TLR Engagement Prevents Transplantation Tolerance (pages 2282–2291)

      L. Chen, T. Wang, P. Zhou, L. Ma, D. Yin, J. Shen, L. Molinero, T. Nozaki, T. Phillips, S. Uematsu, S. Akira, C.-R. Wang, R. L. Fairchild, M.-L. Alegre and A. Chong

      Version of Record online: 7 SEP 2006 | DOI: 10.1111/j.1600-6143.2006.01489.x

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      In a murine heart transplant model, engagement of toll-like receptors prevents anti-CD154-mediated long-term allograft acceptance and prevents intragraft recruitment of CD4+/FoxP3+ T cells.

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      Connective Tissue Growth Factor is a Biomarker and Mediator of Kidney Allograft Fibrosis (pages 2292–2306)

      O. Cheng, R. Thuillier, E. Sampson, G. Schultz, P. Ruiz, X. Zhang, P.S.T. Yuen and R.B. Mannon

      Version of Record online: 4 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01493.x

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      Connective tissue growth factor is demonstrable systemically and locally in mouse kidney allografts undergoing progressive inflammation and fibrosis, and is elevated in serum and urine of human transplant recipients, suggesting that it is compatible with it having a critical role in graft fibrogenesis.

    6. Clinical Science

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      Transplanting the Highly Sensitized Patient: The Emory Algorithm (pages 2307–2315)

      R. A. Bray, J. D. L. Nolen, C. Larsen, T. Pearson, K. A. Newell, K. Kokko, A. Guasch, P. Tso, J. B. Mendel and H. M. Gebel

      Version of Record online: 29 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01521.x

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      The authors describe an algorithm for transplanting highly-sensitized kidney patients based on high resolution HLA antibody analysis and a virtual crossmatch to predict compatibility and a high probability of negativity in the actual final crossmatch. See also editorial by B Hippen in this issue on page 2230.

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      Post-Transplant Anti-HLA Class II Antibodies as Risk Factor for Late Kidney Allograft Failure (pages 2316–2320)

      É. F. Campos, H. Tedesco-Silva, P. G. Machado, M. Franco, J. O. Medina-Pestana and M. Gerbase-DeLima

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01503.x

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      A single-center analysis of first kidney transplant recipients indicates that those with anti-class II antibodies experienced a higher risk of graft loss, when the antibodies were detected before decline in renal function, and increased the risk of graft failure in those which already showed a decline in graft function.

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      Intraoperative Detection of Cell Injury and Cell Death with an 800 nm Near-Infrared Fluorescent Annexin V Derivative (pages 2321–2331)

      S. Ohnishi, J.-L. Vanderheyden, E. Tanaka, B. Patel, A. M. De Grand, R. G. Laurence, K. Yamashita and J. V. Frangioni

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01469.x

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      The use of a fluorescent derivative of annexin V (annexin800) permits real-time assessment of cell injury and death in the operating room, and may be suitable for use during transplant surgery.

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      Prednisolone Suppresses the Function and Promotes Apoptosis of Plasmacytoid Dendritic Cells (pages 2332–2341)

      P. P. C. Boor, H. J. Metselaar, S. Mancham, H. W. Tilanus, J. G. Kusters and J. Kwekkeboom

      Version of Record online: 4 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01476.x

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      In this in vitro study, plasmacytoid dendritic cells, which are important in viral immunity were very susceptible to prednisolone, with decreased functional responses to toll-like receptor stimulation and increased apoptosis.

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      Organ Transplantation in Hereditary Apolipoprotein AI Amyloidosis (pages 2342–2347)

      J. D. Gillmore, A. J. Stangou, H. J. Lachmann, H. J. Goodman, A. D. Wechalekar, J. Acheson, G. A. Tennent, A. Bybee, J. Gilbertson, D. Rowczenio, J. O'Grady, N. D. Heaton, M. B. Pepys and P. N. Hawkins

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01507.x

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      Ten patients received solid organ transplants for hereditary apo-AI amyloidosis, including dual transplants in four cases, with favorable long-term results, supporting the benefits of organ transplantation in this condition.

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      Hepatitis C Recurrence After Liver Transplantation: Viral and Histologic Response to Full-Dose Peg-Interferon and Ribavirin (pages 2348–2355)

      E. Oton, R. Barcena, J. M. Moreno-Planas, V. Cuervas-Mons, A. Moreno-Zamora, C. Barrios, S. Garcia-Garzon, A. Moreno, E. Boullosa-Graña, E. E. Rubio-Gonzalez, M. Garcia-Gonzalez, C. Blesa and M. L. Mateos

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01470.x

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      This multi-center study of pegylated interferon-alpha plus ribavirin in liver transplant patients with histologically proven HCV recurrence greater than 12 months after liver transplantation found 67% end-of-treatment response and 44% sustained virologic response, but with relatively high toxicity.

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      Monitoring of Human Cytomegalovirus-Specific CD4+ and CD8+ T-Cell Immunity in Patients Receiving Solid Organ Transplantation (pages 2356–2364)

      G. Gerna, D. Lilleri, C. Fornara, G. Comolli, L. Lozza, C. Campana, C. Pellegrini, F. Meloni and T. Rampino

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01488.x

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      A new assay for T cell-mediated immunity against CMV indicates that those with more CMV-specific T cells prior to transplantation developed earlier responses with self-resolving infections, whereas those with fewer CMV-specific T cells before transplantation developed later responses which required antiviral treatment.

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      Zygomycosis in Solid Organ Transplant Recipients in a Tertiary Transplant Center and Review of the Literature (pages 2365–2374)

      N. G. Almyroudis, D. A. Sutton, P. Linden, M. G. Rinaldi, J. Fung and S. Kusne

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01496.x

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      In this analysis of ten patients and review of the literature, Zygomycetes infections in solid organ transplant recipients is associated with 49% mortality, particularly in rhinocerebral disease and disseminated disease.

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      Renal Allograft Injury Is Associated with Urinary Tract Infection Caused by Escherichia coli Bearing Adherence Factors (pages 2375–2383)

      J. C. Rice, T. Peng, Y.-f. Kuo, S. Pendyala, L. Simmons, J. Boughton, K. Ishihara, S. Nowicki and B. J. Nowicki

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01471.x

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      Among E. coli specimens collected from renal transplant patients with urinary tract infections, the isolates that expressed virulence factors were associated with greater allograft injury.

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      Effect of Induction Therapy Protocols on Transplant Outcomes in Crossmatch Positive Renal Allograft Recipients Desensitized with IVIG (pages 2384–2390)

      A. A. Vo, M. Toyoda, A. Peng, S. Bunnapradist, M. Lukovsky and S. C. Jordan

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01472.x

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      In patients desensitized using IVIG, patients treated with daclizumab had similar clinical courses to those treated with thymoglobulin, with approximately 20% of both groups undergoing episodes of antibody-mediated rejection.

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      Early and Severe Hyperparathyroidism Associated with Hypercalcemia After Renal Transplant Treated with Cinacalcet (pages 2391–2395)

      N. Leca, M. Laftavi, A. Gundroo, R. Kohli, I. Min, J. Karam, N. Sridhar, G. Blessios, R. Venuto and O. Pankewycz

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01475.x

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      Ten renal transplant patients with hypercalcemia and severe hyperparathyroidism early after renal transplantation were successfully treated with the calcium memetic agent cincalcet, although the correction was not permanent.

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      Short-Term Experience with Early Steroid Withdrawal in African-American Renal Transplant Recipients (pages 2396–2402)

      A. Haririan, D.H. Sillix, K. Morawski, J.M. El-Amm, J. Garnick, M.D. Doshi, M.S. West and S.A. Gruber

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01477.x

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      In African-Americans with kidney transplants who underwent early steroid withdrawal, graft loss, graft function, and rejection rates were similar to controls receiving steroids, but weight gain was less.

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      Routine Coronary Angiography in Diabetic Nephropathy Patients Before Transplantation (pages 2403–2408)

      B. J. Witczak, A. Hartmann, T. Jenssen, A. Foss and K. Endresen

      Version of Record online: 4 SEP 2006 | DOI: 10.1111/j.1600-6143.2006.01491.x

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      In 155 consecutive diabetics awaiting kidney or kidney-pancreas transplants, coronary angiography revealed significant coronary artery stenosis in 45%, of whom more than half were then revascularized.

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      Living Donor Renal Transplantation Using Alemtuzumab Induction and Tacrolimus Monotherapy (pages 2409–2417)

      H. P. Tan, D. J. Kaczorowski, A. Basu, M. Unruh, J. McCauley, C. Wu, J. Donaldson, I. Dvorchik, L. Kayler, A. Marcos, P. Randhawa, C. Smetanka, T. E. Starzl and R. Shapiro

      Version of Record online: 4 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01495.x

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      In 207 living donor renal transplants, alemtuzumab induction and tacrolimus monotherapy resulted in 98% graft survival, 7% incidence of rejection episodes, and no CMV disease. See also editorial by Kirk and Light in this issue on page 2228.

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      Pharmacodynamics of Rituximab in Kidney Allotransplantation (pages 2418–2428)

      H. Genberg, A. Hansson, A. Wernerson, L. Wennberg and G. Tydén

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01497.x

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      This study of 49 kidney transplant recipients receiving a single dose of rituximab therapy demonstrated that 88% showed complete depletion of B cells in peripheral blood with persisting low CD19+ cells at 15 months in most patients, and elimination of B cells from kidney tissue.

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      Living Donor Kidney Transplant Recipients and Clinical Trials: Participation Profiles and Impact on Post-Transplant Care (pages 2429–2435)

      T. V. Brennan, T. F. Fuller, F. Vincenti, S. Chan, C. K. Chang, A. Bostrom, J. K. Zlatunich, S. J. Tomlanovich and S. Feng

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01504.x

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      This single-center study of adult first living donor kidney transplant recipients indicates that those who participated in clinical trials had increased intensity of post-transplant care but comparable outcomes to non-participants.

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      Racial and Ethnic Disparities in Idiopathic Pulmonary Fibrosis: A UNOS/OPTN Database Analysis (pages 2436–2442)

      D. J. Lederer, S. M. Arcasoy, R. G. Barr, J. S. Wilt, E. Bagiella, F. D'Ovidio, J. R. Sonett and S. M. Kawut

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01480.x

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      This retrosepective analysis of patients listed for lung transplantation indicates that mortality among listed patients is higher among blacks and hispanics, in part due to worse lung function at the time of listing.

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      Long-Term Outcome of Adult-to-Adult Living Donor Liver Transplantation for Post-Kasai Biliary Atresia (pages 2443–2448)

      Y. Uchida, M. Kasahara, H. Egawa, Y. Takada, K. Ogawa, Y. Ogura, K. Uryuhara, D. Morioka, S. Sakamoto, Y. Inomata, Y. Kamiyama and K. Tanaka

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01487.x

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      Among patients receiving living donor liver transplants for biliary atresia, post-transplant complications were signficantly higher and survival was lower in adults compared to children.

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      Impact of Recipient MELD Score on Resource Utilization (pages 2449–2454)

      W. K. Washburn, B. H. Pollock, L. Nichols, K. V. Speeg and G. Halff

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01490.x

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      Analysis of liver transplants in a single center indicates that the recipient MELD score is not significantly associated with patient survival but was signficantly associated with costs compared to other demographic and clinical factors.

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      Survival After Adult Liver Transplantation Does Not Correlate with Transplant Center Case Volume in the MELD Era (pages 2455–2462)

      P. G. Northup, T. L. Pruett, G. J. Stukenborg and C. L. Berg

      Version of Record online: 21 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01501.x

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      This analysis of adult liver transplants performed in the United States since the beginning of the MELD allocation system indicates that transplant center case volume is no longer a significant predictor of post-transplant survival.

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      Surgical Techniques and Long-Term Outcomes of Living Donor Liver Transplantation for Budd-Chiari Syndrome (pages 2463–2469)

      T. Yamada, K. Tanaka, Y. Ogura, S. Ko, Y. Nakajima, Y. Takada and S. Uemoto

      Version of Record online: 29 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01505.x

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      In nine patients who underwent live donor liver transplantation for Budd-Chiari syndrome, the challenge of dealing with the retrohepatic segment of the inferior vena cava was handled with vena cava reconstruction without patch plasty in four, whereas five needed cavoplasty with a replacement vein graft.

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      Geographic Differences in Event Rates by Model for End-Stage Liver Disease Score (pages 2470–2475)

      J. P. Roberts, D. M. Dykstra, N. P. Goodrich, S. H. Rush, R. M. Merion and F. K. Port

      Version of Record online: 29 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01508.x

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      Analysis of the MELD scores allows evaluation of geographic differences in transplant access, revealing considerable variability and adjusted transplant rates by region. Simulation indicates that increasing priority to higher MELD candidates would reduce the variation among the donation service areas.

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      Evaluation of Islet Transplantation from Non-Heart Beating Donors (pages 2476–2482)

      H. Noguchi, Y. Iwanaga, T. Okitsu, H. Nagata, Y. Yonekawa and S. Matsumoto

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01499.x

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      Of five patients who received islet transplants from donors with cardiac death, isolated by the Kyoto islet isolation method, three became insulin-independent suggesting the feasibility of this approach.

  4. Brief Communications

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Original Articles:
    5. Brief Communications
    6. Case Reports
    1. You have free access to this content
      The ADP/ATP Ratio: A Novel Predictive Assay for Quality Assessment of Isolated Pancreatic Islets (pages 2483–2487)

      M. Goto, J. Holgersson, M. Kumagai-Braesch and O. Korsgren

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01474.x

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      Measurement of ADP/ATP ratio in isolated pig islets predicted their ability to cure athymic diabetic mice, suggesting this may be useful for predicting performance of human islet preparations.

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      Direct versus Indirect Allorecognition: Visualization of Dendritic Cell Distribution and Interactions During Rejection and Tolerization (pages 2488–2496)

      J. C. Ochando, N. R. Krieger and J. S. Bromberg

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01494.x

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      This experimental mouse heart allograft system in which T cell interactions can be visualized in lymphoid compartments indicates a critical role of distinct anatomical lymphoid compartments in peripheral tolerance induction and maintenance, particularly involving indirect presentation to CD4+ T cells.

  5. Case Reports

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Original Articles:
    5. Brief Communications
    6. Case Reports
    1. You have free access to this content
      Transmission of Syphilis by Solid Organ Transplantation (pages 2497–2499)

      N. J. Cortes, B. Afzali, D. MacLean, D. J. A. Goldsmith, H. O'Sullivan, J. Bingham, D. A. Lewis, E. MacMahon, C. Y. W. Tong and G. Koffman

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01461.x

      Two organ recipients developed serologic evidence of syphilis after receiving kidney transplants from a donor who may have had active infection at the time of donation.

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      Successful Transplantation of Kidneys from a Donor with Myoglobinuric Acute Renal Failure (pages 2500–2501)

      O. Thomusch, C. Gerstenkorn, J. Boehm, T. Arldt, U. Hopt and P. Pisarski

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01462.x

      Both kidneys from a deceased donor with post-traumatic myoglobunuric acute renal failure were transplanted successfully, despite an initial period of delayed graft function.

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      Pancreatic Panniculitis Associated with Allograft Pancreatitis and Rejection in a Simultaneous Pancreas–Kidney Transplant Recipient (pages 2502–2505)

      J. L. Pike, J. C. Rice, R. L. Sanchez, E. B. Kelly and B. C. Kelly

      Version of Record online: 7 SEP 2006 | DOI: 10.1111/j.1600-6143.2006.01463.x

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      This patient developed pancreatic panniculitis in association with manifestations of allograft rejection, suggesting a causal link between the two conditions.

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      Epstein-Barr Virus-Associated Posttransplant Lymphoproliferative Disorder of Donor Origin after Simultaneous Pancreas–Kidney Transplantation Limited to Pancreas Allograft: A Case Report (pages 2506–2511)

      B. Rehbinder, Ch. Wullstein, W. O. Bechstein, M. Probst, K. Engels, S. Kriener, N. Döbert, W. Schwarz, V. Brixner, D. Steffan, S. Gauer, H. Geiger and I. A. Hauser

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01464.x

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      A B cell lymphoma of donor origin that developed in the pancreas six months after pancreas-kidney transplantation was cured by removal of the transplanted organs.

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      Iatrogenic Amyloid Neuropathy in a Japanese Patient After Sequential Liver Transplantation (pages 2512–2515)

      T. Goto, T. Yamashita, M. Ueda, S. Ohshima, K. Yoneyama, M. Nakamura, H. Nanjo, K. Asonuma, Y. Inomata, S. Watanabe, M. Uchino, K. Tanaka and Y. Ando

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01484.x

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      The recipient of a live donor liver transplant from a donor with familial amyloid polyneuropathy subsequently developed clinical symptoms of neuropathy seven years after transplantation.

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      Acute Oxalate Nephropathy: A New Etiology for Acute Renal Failure Following Nonrenal Solid Organ Transplantation (pages 2516–2521)

      C. Lefaucheur, G. S. Hill, C. Amrein, J.-P. Haymann, C. Jacquot, D. Glotz and D. Nochy

      Version of Record online: 1 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01485.x

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      In three non-renal transplants, irreversible acute renal insufficiency developed in relationship to enteric hyperoxaluria associated with prolonged post-operative antibiotic use.

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      Laparoscopic-Assisted Right Lobe Donor Hepatectomy (pages 2522–2525)

      A.J. Koffron, R. Kung, T. Baker, J. Fryer, L. Clark and M. Abecassis

      Version of Record online: 4 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01498.x

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      A living liver donor undergoing laparoscopic hand-assisted right hepatic lobectomy is described. This procedure may be considered for select donors by experienced teams, with the prospect of reducing morbidity of the donation procedure.

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