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American Journal of Transplantation

Cover image for Vol. 6 Issue 7

July 2006

Volume 6, Issue 7

Pages 1501–1751

  1. Editorials

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
    1. You have free access to this content
      Tacrolimus and Sirolimus: When Bad Things Happen to Good Drugs (pages 1501–1502)

      B. Kaplan and A. D. Kirk

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01392.x

      Recent experiences with combinations of calcineurin inhibitor plus sirolimus compared to calcineurin inhibitor plus mycophenolate remind us that claims based on early anecdotal experiences with immunosuppressive protocols must be greeted with caution until controlled trials are available. See also article by Gallon et al in this issue on page 1617.

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      The Conspicuous Costs of More of the Same (pages 1503–1504)

      B. E. Hippen and R. S. Gaston

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01397.x

      Regardless of our discomfort about hidden costs, and our reluctance to consider uncomfortable moral choices, “more of the same” is increasingly unacceptable as a solution to the present crisis in the availability of organ transplants for those in need. See also article by Rothman et al in this issue on page 1524.

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      Uncontrolled DCDs: The Next Step? (pages 1505–1506)

      R. S. Sung and J. D. Punch

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01410.x

      As experience with donation after cardiac death in controlled situations grows, the potential for donation after cardiac death in the less controlled situations should now be carefully examined, and the challenges of utilizing such organs and the ethical and logistical challenges associated with using such organs should be explored. See also article Gagandeep et al in this issue on page 1682.

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      Animal Models of Polyomavirus Nephropathy: Hope and Reality (pages 1507–1509)

      V. Nickeleit

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01400.x

      The development of an animal model of polyoma virus nephropathy is an important objective, but many questions still remain before current models can be accepted as reflecting the conditions of clinical polyoma virus nephropathy. See also article by Larsen et al AJT 6(5):913-922.

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      IVIG vs. Plasmapheresis for Desensitization: Which Is Better? (pages 1510–1511)

      S. Jordan

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01393.x

      The critical issue for the future of desensitization is not the comparison between methods but the development of better tools to assess the extent of sensitization and use the tools optimally to address the problems of the individual.

  2. Minireviews

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
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      Pandemic Influenza and Its Implications for Transplantation (pages 1512–1517)

      D. Kumar and A. Humar

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01364.x

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      It is likely that an influenza pandemic will have significantly worse effects on transplant patients than the general population, but will also have serious implications for transplant programs.

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      T Regulatory Cells and Migration (pages 1518–1523)

      D. Chen and J. S. Bromberg

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01372.x

      Migration behavior of regulatory T cells critically influences their suppressive activities in vivo and expression of chemokine receptors, selectins, and integrins.

  3. Ethics Corner

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
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      The Hidden Cost of Organ Sale (pages 1524–1528)

      S. M. Rothman and D. J. Rothman

      Version of Record online: 29 MAR 2006 | DOI: 10.1111/j.1600-6143.2006.01325.x

      The authors argue that establishing a market in organs may have an unintended adverse consequences on organ donation and a detrimental effect on the medical profession. See also editorial by Robert Gaston in this issue on page 1503.

  4. Original Articles:

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
    1. Basic Science

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      Protective Effect of PEG 35 000 Da on Renal Cells: Paradoxical Activation of JNK Signaling Pathway During Cold Storage (pages 1529–1540)

      D. Dutheil, I. Rioja-Pastor, C. Tallineau, J.-M. Goujon, T. Hauet, G. Mauco and I. Petit-Paris

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01343.x

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      Polyethylene glycol 35 000 Da preserved renal cell viability in vitro during cell preservation, but stimulated Jun N terminal kinase, and exerted a protective effect on cold induced tubular injury in pig kidney.

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      Induction of Tolerance by Exosomes and Short-Term Immunosuppression in a Fully MHC-Mismatched Rat Cardiac Allograft Model (pages 1541–1550)

      H. Pêche, K. Renaudin, G. Beriou, E. Merieau, S. Amigorena and M. C. Cuturi

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01344.x

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      A combination of treatment with LF 15-0195 (a deoxyspergualine analog) with donor MHC antigens from exosomes induced responses that reduced allograft rejection.

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      Tetrahydrobiopterin Attenuates Microvascular Reperfusion Injury Following Murine Pancreas Transplantation (pages 1551–1559)

      M. Maglione, M. Hermann, P. Hengster, S. Schneeberger, W. Mark, P. Obrist, G. Werner-Felmayer, E. R. Werner, R. Margreiter and G. Brandacher

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01345.x

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      Treatment of mouse pancreas grafts with tetrahydropbiopterin reduced microcirculatory damage and histologic evidence of injury, suggesting potential utility in pancreas preservation.

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      Phosphorylated S6 Ribosomal Protein: A Novel Biomarker of Antibody-Mediated Rejection in Heart Allografts (pages 1560–1571)

      E. J. Lepin, Q. Zhang, X. Zhang, P. T. Jindra, L. S. Hong, P. Ayele, M. V. P. Peralta, D. W. Gjertson, J. A. Kobashigawa, W. D. Wallace, M. C. Fishbein and E. F. Reed

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01355.x

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      Human anti-HLA antibodies stimulate phosphorylation of S6 ribosomal protein in cultured endothelial cells, and increased phosphorylation of this protein is also seen in endomyocardial biopsies of heart transplants with antibody-mediated rejection.

    5. Clinical Science

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      Liver Transplantation with the Meld System: A Prospective Study from a Single European Center (pages 1572–1577)

      M. Ravaioli, G. L. Grazi, G. Ballardini, G. Cavrini, G. Ercolani, M. Cescon, M. Zanello, A. Cucchetti, F. Tuci, M. Del Gaudio, G. Varotti, G. Vetrone, F. Trevisani, L. Bolondi and A. D. Pinna

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01354.x

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      This experience in Europe with application of the MELD system in a single center in Italy found that the MELD system improved outcomes for patients with and without hepatocellular carcinoma.

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      Cyclosporin versus Tacrolimus as Primary Immunosuppressant After Liver Transplantation: A Meta-Analysis (pages 1578–1585)

      V. C. McAlister, E. Haddad, E. Renouf, R. A. Malthaner, M. S. Kjaer and L. L. Gluud

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01360.x

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      This systematic review of randomized trials of cyclosporine versus tacrolimus for liver transplantation indicates that using tacrolimus instead of cyclosporine would reduce rejection, steroid-resistant rejection, graft loss, and death.

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      Interferon-Based Combination Anti-Viral Therapy for Hepatitis C Virus After Liver Transplantation: A Review and Quantitative Analysis (pages 1586–1599)

      C. S. Wang, H. H. Ko, E. M. Yoshida, C. A. Marra and K. Richardson

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01362.x

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      This systematic review of databases and studies of combination interferon-ribavirin therapy showed that the therapeutic advantage of pegylated interferon-ribavirin therapy observed in non-transplant chronic HCV infection was markedly attenuated in studies post-transplant such that non-pegylated and pegylated interferon gave similar results post-transplant.

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      Natural History of Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection after Liver Transplantation (pages 1600–1608)

      C.-K. Hui, E. Lau, A. Monto, M. Kim, J. M. Luk, R. T. P. Poon, N. Leung, C.-M. Lo, S.-T. Fan, G. K. K. Lau and T. L. Wright

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01370.x

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      In 118 patients with viral and histologic evidence of recurrent hepatitis C infection coinfected with occult hepatitis B virus after liver transplantation, the occult hepatitis B virus coinfection was not associated with accelerated fibrosis.

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      Mycophenolate Mofetil Use Is Associated with Decreased Risk of Late Acute Rejection in Adult Liver Transplant Recipients (pages 1609–1616)

      R. H. Wiesner, B. J. Steffen, K. M. David, A. H. Chu, R. D. Gordon and J. R. Lake

      Version of Record online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01382.x

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      This study of adult primary liver transplant recipients in the SRTR database found that patients treated with MMF plus tacrolimus showed lower rates of late acute rejection than patients treated with tacrolimus alone.

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      Long-Term Renal Allograft Function on a Tacrolimus-Based, Pred-Free Maintenance Immunosuppression Comparing Sirolimus vs. MMF (pages 1617–1623)

      L. Gallon, N. Perico, B. D. Dimitrov, J. Winoto, G. Remuzzi, J. Leventhal, F. Gaspari and D. Kaufman

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01340.x

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      In renal transplant patients randomized to tacrolimus and mycophenolate versus tacrolimus and sirolimus, kidney loss in the tacrolimus/sirolimus group was significantly greater and GFR was worse, indicating a survival and function disadvantage in the tacrolimus/sirolimus treatment compared to tacrolimus/mycophenolate. See also editorial by Bruce Kaplan in this issue on page 1501.

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      Impaired Renal Allograft Function is Associated with Increased Arterial Stiffness in Renal Transplant Recipients (pages 1624–1630)

      M. Kneifel, A. Scholze, A. Burkert, G. Offermann, L. Rothermund, W. Zidek and M. Tepel

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01341.x

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      Using digital photoplethysmography, this study in renal transplant recipients showed a significant association between renal deterioration and stiffness of large arteries.

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      Incompatible Kidney Donor Candidates' Willingness to Participate in Donor-Exchange and Non-directed Donation (pages 1631–1638)

      A. D. Waterman, E. A. Schenk, A. C. Barrett, B. M. Waterman, J. R. Rodrigue, E. S. Woodle, S. Shenoy, M. Jendrisak and M. Schnitzler

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01350.x

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      This survey of 174 potential donors excluded because of ABO incompatibility indicated considerable willingness to participate in an incompatible kidney donor exchange suggesting that such programs could significantly increase live donation rates, by 1-11%.

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      Urine NGAL and IL-18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation (pages 1639–1645)

      C. R. Parikh, A. Jani, J. Mishra, Q. Ma, C. Kelly, J. Barasch, C. L. Edelstein and P. Devarajan

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01352.x

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      In human kidneys from living and deceased donation, urine NGAL and IL-18 on day 0 predicted the trend in serum creatinine, suggesting a role as early predictive biomarkers of delayed graft function.

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      Recovery and Utilization of Deceased Donor Kidneys from Small Pediatric Donors (pages 1646–1652)

      S. J. Pelletier, M. K. Guidinger, R. M. Merion, M. J. Englesbe, R. A. Wolfe, J. C. Magee and H. W. Sollinger

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01353.x

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      A retrospective analysis of SRTR data for small pediatric donors showed that solitary kidneys had a 78% higher risk of graft loss than en bloc kidneys that had a similar risk to ideal donors confirming that en bloc harvesting is the way to go with such kidneys.

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      Predictive Capacity of Pre-Donation GFR and Renal Reserve Capacity for Donor Renal Function After Living Kidney Donation (pages 1653–1659)

      M. Rook, H. S. Hofker, W. J. Van Son, J. J. Homan van der Heide, R. J. Ploeg and G. J. Navis

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01359.x

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      This study of pre-donation GFR (iothalamate) in living donors showed that GFR, stimulated GFR, and donor age predicted post donation GFR.

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      Interpreting Post-Transplant Proteinuria in Patients with Proteinuria Pre-Transplant (pages 1660–1665)

      M. Myslak, H. Amer, P. Morales, M. E. Fidler, J. M. Gloor, T. S. Larson, M. D. Stegall and F. G. Cosio

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01361.x

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      In this study of patients with proteinuria before renal transplantation, proteinuria declined rapidly after transplantation, and proteinuria >1.5 g/day or an absolute increase >0.5 g/day was associated with glomerular pathology in the allograft.

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      A Prospective, Randomized, Multicenter Trial of Tacrolimus-Based Therapy with or without Basiliximab in Pediatric Renal Transplantation (pages 1666–1672)

      R. Grenda, A. Watson, K. Vondrak, N. J. A. Webb, J. Beattie, M. Fitzpatrick, M. A. Saleem, R. Trompeter, D. V. Milford, N. E. Moghal, D. Hughes, F. Perner, S. Friman, R. Van Damme-Lombaerts and F. Janssen

      Version of Record online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01367.x

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      The 6-month multicenter randomized controlled trial in pediatric renal transplants showed that basiliximab added to a tacrolimus-based regimen was safe but did not improve clinical efficacy: biopsy-proven rejection rates were approximately 20% in both groups.

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      Upregulation of ADAM19 in Chronic Allograft Nephropathy (pages 1673–1681)

      W. B. W. H. Melenhorst, M. C. Van Den Heuvel, C. A. Stegeman, J. Van Der Leij, S. Huitema, A. Van Den Berg and H. Van Goor

      Version of Record online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01384.x

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      ADAM19, a disintegrin and metalloproteinase involved in cell-cell and cell-matrix interactions was strongly expressed in kidney allografts with fibrosis and atrophy (CAN), suggesting a role in these damaged kidneys.

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      Expanding the Donor Kidney Pool: Utility of Renal Allografts Procured in a Setting of Uncontrolled Cardiac Death (pages 1682–1688)

      S. Gagandeep, L. Matsuoka, R. Mateo, Y. W. Cho, Y. Genyk, L. Sher, J. Cicciarelli, S. Aswad, N. Jabbour and R. Selby

      Version of Record online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01386.x

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      In kidney transplants obtained by donation after cardiac death, reported to UNOS, the kidneys from uncontrolled DBD donors showed longer ischemic times but similar delayed graft function and survival rates to the kidneys from controlled DCD donors, confirming that this source of kidneys is suitable. See also editorial by Sung and Punch in this issue on page 1505.

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      The Expanded Criteria Donor Policy: An Evaluation of Program Objectives and Indirect Ramifications (pages 1689–1695)

      J. D. Schold, R. J. Howard, M. J. Scicchitano and H.-U. Meier-Kriesche

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01390.x

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      This study of the impact of the extended criteria donor policy in 2002 indicates that the full impact of the program may require development and adoption of more uniform ECD listing practices.

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      Improved Islet Yields from Pancreas Preserved in Perflurocarbon Is Via Inhibition of Apoptosis Mediated by Mitochondrial Pathway (pages 1696–1703)

      S. Ramachandran, N. M. Desai, T. A. Goers, N. Benshoff, B. Olack, S. Shenoy, M. D. Jendrisak, W. C. Chapman and T. Mohanakumar

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01368.x

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      This study of human islets isolated from pancreata preserved in perfluorocarbon showed decreased expression of proapoptotic genes bad, bax and caspases, and decreased apoptosis via the mitochondrial pathway, as well as increased expression of inhibitor of anti-apoptotic genes IAP and survivin.

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      Detection of Insulin mRNA in the Peripheral Blood after Human Islet Transplantion Predicts Deterioration of Metabolic Control (pages 1704–1711)

      T. Berney, A. Mamin, A. M. James Shapiro, B. Ritz-Laser, M.-C. Brulhart, C. Toso, S. Demuylder-Mischler, M. Armanet, R. Baertschiger, A. Wojtusciszyn, P.-Y. Benhamou, D. Bosco, P. Morel and J. Philippe

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01373.x

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      Detection of insulin mRNA in the circulating blood of islet transplant patients in this study of 19 islet transplant patients was associated with adverse events, suggesting a method for predicting islet damage.

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      Sensitization Following LVAD Implantation Using Leucodepleted Blood Is Not Due to HLA Antibodies (pages 1712–1717)

      H. Newell, J. D. Smith, P. Rogers, E. Birks, A. J. Danskine, R. E. Fawson and M. L. Rose

      Version of Record online: 13 APR 2006 | DOI: 10.1111/j.1600-6143.2006.01342.x

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      In 51 patients receiving left ventricular assist devices, no patient developed HLA antibodies but 24 produced antibodies against albumin which masqueraded as antibodies against HLA in solid phase antibody assays.

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      Bilateral Hand Transplantation: Six Years After the First Case (pages 1718–1724)

      P. Petruzzo, L. Badet, A. Gazarian, M. Lanzetta, H. Parmentier, J. Kanitakis, A. Sirigu, X. Martin and J. M. Dubernard

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01369.x

      Six years and two years respectively after hand transplants, the recipients show significant sensory motor recovery and the first recipient has been performing daily activities and both expressed satisfaction with their grafted hands.

  5. Brief Communications

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
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      Renal Allograft Biopsies with Borderline Changes: Predictive Factors of Clinical Outcome (pages 1725–1730)

      K. Dahan, V. Audard, F. Roudot-Thoraval, D. Desvaux, M. Abtahi, H. Mansour, M. Kumal, P. Lang and P. Grimbert

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01348.x

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      In 91 patients with “borderline changes” on renal allograft biopsies for cause, histologic stage and time to changes correlated with serum creatinine at one year, suggesting prognostic value to borderline changes, but treatment had no apparent impact on functional outcome.

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      How Useful is PET/CT Imaging in the Management of Post-Transplant Lymphoproliferative Disease After Liver Transplantation? (pages 1731–1736)

      L. McCormack, T. I. Hany, M. Hübner, H. Petrowsky, B. Mullhaupt, A. Knuth, F. Stenner and P.-A. Clavien

      Version of Record online: 15 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01358.x

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      In four patients with PTLD investigated with PET/CT, this method provided new information that changed medical management in three of the four patients.

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      Medicare Part D Coverage and Its Influence on Transplant Patients' Out-of-Pocket Prescription Expenses (pages 1737–1742)

      M. A. Chisholm and E. Roberts

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01371.x

      The addition of Medicare Part D for USA transplant recipients may reduce medication expenses but is rather complicated to use to obtain maximal benefit.

  6. Case Report

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Ethics Corner
    5. Original Articles:
    6. Brief Communications
    7. Case Report
    1. You have free access to this content
      Factor XII Deficiency Acquired by Orthotopic Liver Transplantation: Case Report and Review of the Literature (pages 1743–1745)

      N. K. Osborn, Y. Ustundag, C. S. Zent, R. H. Wiesner, C. B. Rosen and K. V. Narayanan Menon

      Version of Record online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01363.x

      In this case, a patient transplanted for Budd-Chiari syndrome showed persistent elevated aPTT, apparently due to a deficiency of this clotting factor in the donor.

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      Acute Renal Allograft Rejection Following Pegylated IFN-α Treatment for Chronic HCV in a Repeat Allograft Recipient on Hemodialysis: A Case Report (pages 1746–1751)

      S. J. Carbognin, N. M. Solomon, F. E. Yeo, S. J. Swanson, E. M. Bohen, J. M. Koff, S. G. Sabnis and K. C. Abbott

      Version of Record online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01374.x

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      In this patient with a failed renal allograft, pegylated interferon-a therapy initiated six months after return to dialysis was associated with fevers due to acute rejection of the allograft, requiring nephrectomy.

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