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American Journal of Transplantation

Cover image for Vol. 6 Issue 8

August 2006

Volume 6, Issue 8

Pages 1753–1987

  1. Editorials

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Histologic Findings from Positive Crossmatch or ABO-Incompatible Renal Allografts: Accomodation or Chronic Allograft Injury? (pages 1753–1754)

      B. Sis, B. Kaplan and P. F. Halloran

      Article first published online: 13 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01466.x

      In human and primate studies, the presence of circulating antibody and C4d staining is associated with a variety of clinical phenotypes ranging from minimal to fulminant. But even when the clinical findings are minimal the time dependency of some of these phenotypes should invite caution before predicting the risk of future problems in an organ with C4d and circulating donor-specific antibody. See also articles by Haas et al on page 1829, Colvin et al on page 1790, Gloor et al in this issue on page 1841, and the minireview by Soleimani et al in this issue on page 1781.

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      Striving for Perfection: Evaluation of the Right Lobe Live Liver Donor (pages 1755–1756)

      E. A. Pomfret and S. Feng

      Article first published online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01426.x

      Live donor adult liver transplantation is a sophisticated and cutting edge surgical innovation that improves and/or extends the life of the recipient but at considerable potential harm to the donor. See also article by Trotter et al in this issue on page 1882.

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      Reflux of Bile Acids: An Innate Problem of Lung Transplantation (pages 1757–1758)

      S. M. Palmer

      Article first published online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01425.x

      The role of gastroesophageal reflux and of bile acids in the bronchiolitis obliterans syndrome should now be subjected to multicenter studies to determine the effectiveness of potential therapies. See also article by D'Ovidio et al in this issue on page 1930.

  2. Minireviews

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      Developments in Clinical Islet, Liver Thoracic, Kidney and Pancreas Transplantation in the Last 5 Years (pages 1759–1767)

      S. Feng, M. Barr, J. Roberts, R. Oberbauer and B. Kaplan

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01402.x

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      Some of the significant developments in the last five years in organ transplantation have included islet transplantation, adult-to-adult living donor liver transplantation, use of ventricular assist devices in heart transplantation, use of ventricular assist devices as destination therapy for end-stage heart disease, and new allocation polices in liver and lung transplantation.

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      The Last 5 Years of Basic Science Investigation in Transplant Immunology (pages 1768–1773)

      A. W. Thomson and R. L. Fairchild

      Article first published online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01424.x

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      The last five years have seen considerable progress in basic understanding of innate immunity, alloreactive T cell homing, costimulation blockade, regulatory and memory T cells, and antigen presentation and the role of cellular microenvironment, among others.

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      An Appraisal of Tolerance in Liver Transplantation (pages 1774–1780)

      J. Lerut and A. Sanchez-Fueyo

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01396.x

      Accumulated clinical experience indicates that immunosuppressive drug weaning is feasible in about 20% of selected liver transplant recipients, with 12–76% acute rejection mostly mild, but this “trial and error” method continues to be limited by the lack of a clinically validated treatment stopping rule predicting success.

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      Role of Alloantibodies in the Pathogenesis of Graft Arteriosclerosis in Cardiac Transplantation (pages 1781–1785)

      B. Soleimani, R. I. Lechler, P. I. Hornick and A. J. T. George

      Article first published online: 12 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01401.x

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      There is a strong correlation between the presence of antidonor antibodies in graft arteriopathy and antidonor alloantibody, but this may be only one of a number of pathologic processes.

  3. Personal Viewpoint

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      We Have an Obligation to Provide Organs for Transplantation After We Die (pages 1786–1789)

      R. J. Howard

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01419.x

      Dr. Howard argues that the provision of organs for transplantation is not an optional gift, but rather a moral obligation or duty for all individuals.

  4. Original Articles:

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
    1. Basic Science

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      Chronic Antibody Mediated Rejection of Renal Allografts: Pathological, Serological and Immunologic Features in Nonhuman Primates (pages 1790–1798)

      R. N. Smith, T. Kawai, S. Boskovic, O. Nadazdin, D. H. Sachs, A. B. Cosimi and R. B. Colvin

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01351.x

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      Pathologic studies in monkeys with long-surviving kidney transplants showed that the group with C4d deposition in peritubular capillaries had circulating alloantibodies and developed allograft glomerulopathy and/or arteriopathy, confirming associations previously reported in humans between persistent alloantibodies and kidney deterioration. See also editorial by Sis, Kaplan and Halloran in this issue on page 1753.

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      CD4+25+ Regulatory T Cells Limit Th1-Autoimmunity by Inducing IL-10 Producing T Cells Following Human Lung Transplantation (pages 1799–1808)

      A. Bharat, R. C. Fields, N. Steward, E. P. Trulock, G. A. Patterson and T. Mohanakumar

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01383.x

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      This study of blood cells from patients with lung transplants demonstrated a population of IL10 producing T cells reactive to collagen V, which may help to suppress collagen V-specific effector T cells.

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      TGF-β Inhibition of CTL Re-Stimulation Requires Accessory Cells and Induces Peroxisome-Proliferator-Activated Receptor-Gamma (PPAR-γ) (pages 1809–1819)

      A. M. VanBuskirk, G. B. Lesinski, K. J. Nye, W. E. Carson and L. D. Yee

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01387.x

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      The ability of TGF-β to inhibit memory CTL restimulation requires an accessory cell and may be mediated by PPAR-γ induction in the accessory cell.

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      Minimization of Immunosuppressive Therapy After Islet Transplantation: Combined Action of Heme Oxygenase-1 and PEGylation to Islet (pages 1820–1828)

      D. Y. Lee, S. Lee, J. H. Nam and Y. Byun

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01414.x

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      In rat islet transplants the combination of induction of HO-1 expression, low-dose cyclosporine, and PEGylated islets proved to be a successful therapy.

    5. Clinical Science

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      C4d and C3d Staining in Biopsies of ABO- and HLA-Incompatible Renal Allografts: Correlation with Histologic Findings (pages 1829–1840)

      M. Haas, M. H. Rahman, L. C. Racusen, E. S. Kraus, S. M. Bagnasco, D. L. Segev, C. E. Simpkins, D. S. Warren, K. E. King, A. A. Zachary and R. A. Montgomery

      Article first published online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01356.x

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      This retrospective biopsy study showed that ABO incompatible kidney biopsies were 25% positive for C4d staining in protocol biopsies and 60% positive in biopsies for graft dysfunction, but unlike HLA antibodies C4d deposition in most ABO incompatible grafts was not correlated with histologic injury. See also editorial by Sis, Kaplan, and Halloran in this issue on page 1753.

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      Histologic Findings One Year After Positive Crossmatch or ABO Blood Group Incompatible Living Donor Kidney Transplantation (pages 1841–1847)

      J. M. Gloor, F. G. Cosio, D. J. Rea, H. M. Wadei, J. L. Winters, S. B. Moore, S. R. DeGoey, D. J. Lager, J. P. Grande and M. D. Stegall

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01416.x

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      This series of protocol biopsies one year post-transplant in patients with positive crossmatches or ABO incompatible kidneys found that transplant glomerulopathy was more frequent than in conventional allografts, and was associated with a prior episode of antibody-mediated rejection indicating that in one year biopsies transplant glomerulopathy mainly occurs in those who have prior antibody-mediated rejection episodes. See also editorial by Sis, Kaplan and Halloran in this issue on page 1753.

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      FTY720/Cyclosporine Regimens in De Novo Renal Transplantation: A 1-Year Dose-Finding Study (pages 1848–1857)

      S. Mulgaonkar, H. Tedesco, F. Oppenheimer, R. Walker, U. Kunzendorf, G. Russ, A. Knoflach, Y. Patel, R. Ferguson and FTYA121 study group

      Article first published online: 12 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01404.x

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      This phase II study found that FTY720 2.5 mg plus full-dose cyclosporine and FTY720 5 mg plus reduced-dose cyclosporine were safe and effective in de novo renal transplant patients over 12 months of observation.

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      Kidney Transplantation Without Prior Dialysis in Children: The Eurotransplant Experience (pages 1858–1864)

      K. Cransberg, J. M. A. Smits, G. Offner, J. Nauta and G. G. Persijn

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01405.x

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      This review of 1113 first kidney transplants in children in Europe found that transplantation before starting dialysis was at least as good as post-dialysis transplantation, and recommends that pre-emptive transplantation in children with end-stage renal disease be considered.

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      Post-Transplant sCD30 and Neopterin as Predictors of Chronic Allograft Nephropathy: Impact of Different Immunosuppressive Regimens (pages 1865–1874)

      R. Weimer, C. Süsal, S. Yildiz, A. Staak, S. Pelzl, F. Renner, H. Dietrich, V. Daniel, S. Kamali-Ernst, W. Ernst, W. Padberg and G. Opelz

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01407.x

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      This prospective study of renal transplant patients found that elevated sCD30 and neoptrin are associated with graft deterioration, and that tacrolimus is associated with lower levels of sCD30 and neoptrin.

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      Kidney Transplantation Outcomes in Canadian Aboriginals (pages 1875–1881)

      C. L. C. Weber, D. N. Rush, J. R. Jeffery, M. Cheang and M. E. Karpinski

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01409.x

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      In kidney transplants in Manitoba, aboriginal recipients experienced greater post-transplant weight gain and diabetes, and inferior graft and patient survival, compared to Caucasians in the Manitoba population.

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      Outcomes of Donor Evaluations for Adult-to-Adult Right Hepatic Lobe Living Donor Liver Transplantation (pages 1882–1889)

      J. F. Trotter, J. Campsen, T. Bak, M. Wachs, L. Forman, G. Everson and I. Kam

      Article first published online: 29 MAR 2006 | DOI: 10.1111/j.1600-6143.2006.01322.x

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      In this study of patients undergoing evaluation as adult-to-adult living liver donors, less than half were suitable and the acceptance rate has declined over time. See also editorial by Pomfret and Feng in this issue on page 1755.

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      Prevalence and Risk Factors for Diabetes Mellitus in Moderate Term Survivors of Liver Transplantation (pages 1890–1895)

      S. Saab, A. Shpaner, Y. Zhao, I. Brito, F. Durazo, S. Han, D. G. Farmer, R. M. Ghobrial, H. Yersiz, L. I. Goldstein, M. J. Tong and R. W. Busuttil

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01385.x

      In 253 adult liver transplant recipients, multivariate analysis demonstrated that the development of diabetes was associated with male gender.

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      A Randomized Trial of Exercise and Dietary Counseling After Liver Transplantation (pages 1896–1905)

      J. B. Krasnoff, A. Q. Vintro, N. L. Ascher, N. M. Bass, S. M. Paul, M. J. Dodd and P. L. Painter

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01391.x

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      Nutrition and exercise modifications initiated early after orthotopic liver transplantation and subjected to regular follow-up resulted in improvement in exercise capacity and body composition in this cohort of 115 liver transplant recipients randomized to either usual care or combined interventions.

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      CMV-IVIG for Prevention of Epstein Barr Virus Disease and Posttransplant Lymphoproliferative Disease in Pediatric Liver Transplant Recipients (pages 1906–1912)

      M. Green, M. G. Michaels, B. Z. Katz, M. Burroughs, D. Gerber, B. L. Shneider, K. Newell, D. Rowe and J. Reyes

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01394.x

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      A randomized trial of CMV-IVIG in pediatric liver transplants showed no significant differences between treatment and placebo in terms of EBV disease and PTLD.

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      Randomized Trial of Basiliximab Induction versus Steroid Therapy in Pediatric Liver Allograft Recipients Under Tacrolimus Immunosuppression (pages 1913–1921)

      M. Spada, W. Petz, A. Bertani, S. Riva, A. Sonzogni, M. Giovannelli, E. Torri, G. Torre, M. Colledan and B. Gridelli

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01406.x

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      In 72 pediatric liver transplants, 36 randomized to tacrolimus and basiliximab experienced less rejection and less infection than those on tacrolimus plus steroid, suggesting that the tacrolimus-basiliximab combination is safe and effective.

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      The Impact of Diabetes Mellitus on Fibrosis Progression in Patients Transplanted for Hepatitis C (pages 1922–1929)

      M. R. Foxton, A. Quaglia, P. Muiesan, M. A. Heneghan, B. Portmann, S. Norris, N. D. Heaton and J. G. O'Grady

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01408.x

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      In 163 patients undergoing primary liver transplant for HCV, progression was associated with older donor age, and diabetes mellitus in the recipient, with the two factors together combining to give an 8.38 fold increased risk of progression to severe fibrosis.

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      The Effect of Reflux and Bile Acid Aspiration on the Lung Allograft and Its Surfactant and Innate Immunity Molecules SP-A and SP-D (pages 1930–1938)

      F. D'Ovidio, M. Mura, R. Ridsdale, H. Takahashi, T. K. Waddell, M. Hutcheon, D. Hadjiliadis, L. G. Singer, A. Pierre, C. Chaparro, C. Gutierrez, L. Miller, G. Darling, M. Liu, M. Post and S. Keshavjee

      Article first published online: 8 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01357.x

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      This prospective study of human lung allografts showed that BOS was associated with abnormal esophageal pH or bioacids in the broncho-alveolar lavage fluid, with lower levels of surfactant proteins and phospholipids in the BALF. Also see editorial by Palmer in this issue on page 1757.

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      Trajectories of Change in Quality of Life in 12-Month Survivors of Lung or Heart Transplant (pages 1939–1947)

      L. Myaskovsky, M. A. Dew, M. L. McNulty, G. E. Switzer, A. F. DiMartini, R. L. Kormos and K. R. McCurry

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01395.x

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      Adult heart or lung recipients participating in semi-structured interviews, demonstrated similar features, with higher quality of life associated with optimism and support from friends, and lower in association with avoidant coping strategies.

  5. Brief Communications

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      Favorable Long-Term Outcome after Liver-Kidney Transplant for Recurrent Hemolytic Uremic Syndrome Associated with a Factor H Mutation (pages 1948–1952)

      J. M. Saland, S. H. Emre, B. L. Shneider, C. Benchimol, S. Ames, J. S. Bromberg, G. Remuzzi, L. Strain and T. H. J. Goodship

      Article first published online: 17 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01375.x

      This child with hemolytic uremic syndrome due to complement factor H mutations leading to end-stage renal disease, and a failed kidney transplant from recurrent disease, experienced a good result from combined liver-kidney transplantation.

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      Death on the Kidney Waiting List—Good Candidates or Not? (pages 1953–1956)

      V. Casingal, E. Glumac, M. Tan, M. Sturdevant, T. Nguyen and A. J. Matas

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01399.x

      This review of patients who died awaiting kidney transplantation found that many were young first-time candidates with low PRA.

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      Reduced Priority MELD Score for Hepatocellular Carcinoma Does Not Adversely Impact Candidate Survival Awaiting Liver Transplantation (pages 1957–1962)

      P. Sharma, A. M. Harper, J. L. Hernandez, T. Heffron, D. C. Mulligan, R. H. Wiesner and V. Balan

      Article first published online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01411.x

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      The change in the MELD score in 2003 that reduced the priority for HCC candidates on the waiting list did not reduce their survival on the waiting list or their ability to obtain a liver transplant within a reasonable time.

  6. Case Reports

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      Reverse Diastolic Intrarenal Flow Due to Calcineurin Inhibitor (CNI) Toxicity (pages 1963–1967)

      C. A. Böger, P. Rümmele, M. J. Mihatsch, B. Banas and B. K. Krämer

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01381.x

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      This patient on tacrolimus and sirolimus developed acute renal failure eight months after kidney transplantation, associated with doppler sonographic evidence of severe vessel narrowing and reverse diastolic intrarenal blood flow, possibly related to the tacrolimus-sirolimus combination.

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      Ureteral Reconstruction and Bladder Augmentation Using Intestinal Allograft in a Modified Multivisceral Transplant Patient (pages 1968–1971)

      H. Haider, A. Tzakis, M. Manoharan, G. Selvaggi, S. Nishida, D. Levi and G. Ciancio

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01388.x

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      A segment of transplanted ileum was used as a conduit for ureteral reconstruction and bladder augmentation in this multi-visceral transplant for Gardner's syndrome.

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      Successful Kidney Transplantation from Donor with Marfan's Syndrome (pages 1972–1974)

      S. Farese, B. Vogt, F. J. Frey and U. Huynh-Do

      Article first published online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01389.x

      Two patients received kidneys from a brain-dead donor with Marfan's syndrome with suitable outcomes despite delayed graft function.

  7. Letters to the Editor

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      Response to Lamivudine-Resistant Hepatitis B Virus Infection Postliver Transplantation from a Hepatitis B Core Antibody Donor (page 1981)

      R. C. Dickson, H. Bonatti, J. Aranda-Michel, J. Mendez and J. L. Steers

      Article first published online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01438.x

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      Liver Transplantation for Classical Maple Syrup Urine Disease (page 1982)

      P. Buss and D. N. Tornberg

      Article first published online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01439.x

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      PTLD Visualization by FDG-PET: Improved Detection of Extranodal Localizations (pages 1984–1985)

      N. A. Bakker, J. Pruim, W. De Graaf, W. J. Van Son, E. J. Van Der Jagt and G. W. Van Imhoff

      Article first published online: 13 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01459.x

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  8. Erratum

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Personal Viewpoint
    5. Original Articles:
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    9. Erratum
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      Erratum (page 1986)

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01422.x

      This article corrects:

      Long-term Cardiac Outcomes in Renal Transplant Recipients Receiving Fluvastatin: The ALERT Extension Study

      Vol. 5, Issue 12, 2929–2936, Article first published online: 18 NOV 2005

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      Erratum (page 1987)

      Article first published online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01423.x

      This article corrects:

      Thoracic Organ Transplantation in the United States, 1995–2004

      Vol. 6, Issue 5p2, 1188–1197, Article first published online: 5 APR 2006

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