Myeloma Responses and Tolerance Following Combined Kidney and Nonmyeloablative Marrow Transplantation: In Vivo and In Vitro Analyses (pages 2121–2133)
Y. Fudaba, T. R. Spitzer, J. Shaffer, T. Kawai, T. Fehr, F. Delmonico, F. Preffer, N. Tolkoff-Rubin, B. R. Dey, S. L. Saidman, A. Kraus, T. Bonnefoix, S. McAfee, K. Power, K. Kattleman, R. B. Colvin, D. H. Sachs, A. B. Cosimi and M. Sykes
Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01434.x
Six patients with renal failure induced by multiple myeloma received simultaneous kidney and bone marrow transplants from HLA-identical sibling donors following conditioning with cyclophosphamide, ATG, and thymic irradiation, and cyclosporine post-transplant with donor lymphocyte infusions, and all six kidneys have been accepted long-term, despite the presence of donor marrow rejection and anti-donor responses in vitro in some patients. See also editorial by Newell and Larsen in this issue on page 1989.