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American Journal of Transplantation

Cover image for Vol. 6 Issue 9

September 2006

Volume 6, Issue 9

Pages 1989–2223

  1. Editorial

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Toward Transplantation Tolerance: A Large Step on a Long Road (pages 1989–1990)

      K. A. Newell and C. P. Larsen

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01481.x

      The report of successful non-myeloablative conditioning in patients with malignancies undergoing HLA-identical kidney transplant represents an interesting development, but its potential outside of this application is far from clear. Also see article by Fudaba et al on page 2121.

  2. Minireviews

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Mycophenolate Mofetil and Sirolimus Combination in Renal Transplantation (pages 1991–1999)

      J. M. Grinyó and J. M. Cruzado

      Version of Record online: 23 MAY 2006 | DOI: 10.1111/j.1600-6143.2006.01398.x

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      The sirolimus-MMF combination in clinical experience has proven to be effective as prophylaxis against rejection with some improvements in renal function, but the high rate of discontinuation due to adverse events is a concern.

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      BK Virus Infection in Transplant Recipients: An Overview and Update (pages 2000–2005)

      P. Randhawa and D. C. Brennan

      Version of Record online: 9 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01403.x

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      Increasing recognition of BK virus infection after kidney transplantation has reduced the incidence and consequences of BK nephropathy, but reliable antiviral drugs are still not available.

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      The Significance of Subclinical Rejection and the Value of Protocol Biopsies (pages 2006–2012)

      B. J. Nankivell and J. R. Chapman

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01436.x

      Protocol biopsies of renal transplant patients have the potential for improving outcomes, but further trials to evaluate their actual cost benefit and utility are required.

  3. Original Articles:

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
    1. Basic Science

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      FK330, a Novel Inducible Nitric Oxide Synthase Inhibitor, Prevents Ischemia and Reperfusion Injury in Rat Liver Transplantation (pages 2013–2022)

      S. Tsuchihashi, F. Kaldas, N. Chida, Y. Sudo, K. Tamura, Y. Zhai, B. Qiao, R. W. Busuttil and J. W. Kupiec-Weglinski

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01435.x

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      Treatment of rats with FK330, a specific inhibitor of inducible nitric oxide synthase, resulted in a number of improved measurements of early and late liver transplant outcomes, with decreases in lymphocyte activation and inflammation markers.

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      Prolongation of Allograft Survival by Administration of Anti-CD45RB Monoclonal Antibody Is Due to Alteration of CD45RBhi: CD45RBlo T-Cell Proportions (pages 2023–2034)

      P. P. W. Luke, J. P. Deng, D. Lian, P. J. O'Connell, B. Garcia, A. M. Jevnikar and R. Zhong

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01451.x

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      CD45RBhi T cells are associated with effector functions and when infused reduced graft survival, whereas CD45RBlo CD4 T cells have opposite effects and are associated with Foxp3.

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      Rat Cytomegalovirus Infection Interferes with Anti-CD4 mAb-(RIB 5/2) Mediated Tolerance and Induces Chronic Allograft Damage (pages 2035–2045)

      A. Pascher, S. Proesch, J. Pratschke, A. Reutzel-Selke, B. Sawitzki, M. Lehmann, S. G. Tullius, P. Neuhaus, H.-D. Volk and P. Reinke

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01453.x

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      In a protocol using a monoclonal anti-CD4 antibody that produces robust allograft survival, rat cytomegalovirus infection interfered with long-term survival, with deterioration of function and morphology, indicating that CMV infection may interfere with favorable immunologic changes induced by anti-CD4 antibody.

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      Aspirin-Treated Human DCs Up-Regulate ILT-3 and Induce Hyporesponsiveness and Regulatory Activity in Responder T Cells (pages 2046–2059)

      M. Buckland, C. B. Jago, H. Fazekasova, K. Scott, P. H. Tan, A. J. T. George, R. Lechler and G. Lombardi

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01450.x

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      Treatment of human peripheral blood dendritic cells in vitro with aspirin reduces their expression of HLA-DR and costimulators and increases expression of ILT-3, associated with reduced ability to stimulate allogeneic T cells, similar to that of immature dendritic cells.

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      Improved Human Islet Isolation Using Nicotinamide (pages 2060–2068)

      H. Ichii, X. Wang, S. Messinger, A. Alvarez, C. Fraker, A. Khan, Y. Kuroda, L. Inverardi, J. A. Goss, R. Alejandro and C. Ricordi

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01452.x

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      Addition of nicotinamide to islet isolation processing medium significantly improved the yield of islets, such that more islet preparations were suitable for clinical transplantation.

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      mTOR Inhibition Induces Endothelial Progenitor Cell Death (pages 2069–2079)

      S. G. Miriuka, V. Rao, M. Peterson, L. Tumiati, D. H. Delgado, R. Mohan, D. Ramzy, D. Stewart, H. J. Ross and T. K. Waddell

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01433.x

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      This in vitro study of human peripheral blood mononuclear cells found that sirolimus, but not cyclosporine or tacrolimus, induced endothelial cell progenitor death, possibly by blocking survival signals for growth factors.

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      Myofibroblast Transdifferentiation in Obliterative Bronchiolitis: TGF-β Signaling Through Smad3-Dependent and -Independent Pathways (pages 2080–2088)

      A. M. Ramirez, Z. Shen, J. D. Ritzenthaler and J. Roman

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01430.x

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      This in vitro study of airway fibroblasts found that TGF-β 1 stimulates myofibroblasts through both Smad3-dependent and Smad3-independent pathways, suggesting that either of these pathways could play a role in airway disease and excessive matrix deposition after lung transplantation.

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      MiHA Reactive CD4 and CD8 T-Cells Effect Resistance to Hematopoietic Engraftment Following Reduced Intensity Conditioning (pages 2089–2098)

      Z. F. Zimmerman and R. B. Levy

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01428.x

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      Reduced intensity conditioning prior to allogeneic hematopoietic cell transplantation is limited by T cell mediated resistance to engraftment, in which host CD4 T cells play a critical role.

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      Preventing Renal Ischemia–Reperfusion Injury Using Small Interfering RNA by Targeting Complement 3 Gene (pages 2099–2108)

      X. Zheng, B. Feng, G. Chen, X. Zhang, M. Li, H. Sun, W. Liu, C. Vladau, R. Liu, A. M. Jevnikar, B. Garcia, R. Zhong and W.-P. Min

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01427.x

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      Small interfering RNA (siRNA) directed against C3 proved effective in reducing renal ischemia reperfusion injury even when delivered systemically.

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      Tubulitis and Epithelial Cell Alterations in Mouse Kidney Transplant Rejection Are Independent of CD103, Perforin or Granzymes A/B (pages 2109–2120)

      G. Einecke, T. Fairhead, L. G. Hidalgo, B. Sis, P. Turner, L.-F. Zhu, R. C. Bleackley, G. A. Hadley, K. S. Famulski and P. F. Halloran

      Version of Record online: 26 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01483.x

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      The hallmark of kidney rejection, tubulitis, is associated with profound changes in the epithelium (e.g. loss of cadherins), and does not require the cytotoxic functions of lymphocytes, suggesting that tubulitis is an indirect consequence of the inflammatory process in the interstitium rather than a lymphocyte attack on the epithelium.

    11. Clinical Science

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      Myeloma Responses and Tolerance Following Combined Kidney and Nonmyeloablative Marrow Transplantation: In Vivo and In Vitro Analyses (pages 2121–2133)

      Y. Fudaba, T. R. Spitzer, J. Shaffer, T. Kawai, T. Fehr, F. Delmonico, F. Preffer, N. Tolkoff-Rubin, B. R. Dey, S. L. Saidman, A. Kraus, T. Bonnefoix, S. McAfee, K. Power, K. Kattleman, R. B. Colvin, D. H. Sachs, A. B. Cosimi and M. Sykes

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01434.x

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      Six patients with renal failure induced by multiple myeloma received simultaneous kidney and bone marrow transplants from HLA-identical sibling donors following conditioning with cyclophosphamide, ATG, and thymic irradiation, and cyclosporine post-transplant with donor lymphocyte infusions, and all six kidneys have been accepted long-term, despite the presence of donor marrow rejection and anti-donor responses in vitro in some patients. See also editorial by Newell and Larsen in this issue on page 1989.

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      Prophylactic Versus Preemptive Oral Valganciclovir for the Management of Cytomegalovirus Infection in Adult Renal Transplant Recipients (pages 2134–2143)

      J. A. Khoury, G. A. Storch, D. L. Bohl, R. M. Schuessler, S. M. Torrence, M. Lockwood, M. Gaudreault-Keener, M. J. Koch, B. W. Miller, K. L. Hardinger, M. A. Schnitzler and D. C. Brennan

      Version of Record online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01413.x

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      This randomized comparison of prophylactic valganciclovir versus pre-emptive therapy of kidney transplant recipients at risk for CMV showed that both approaches were effective with similar costs.

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      Blood T-Cell Repertoire in Idiopathic Nephrotic Syndrome Recurrence Following Kidney Transplantation (pages 2144–2151)

      C. Hervé, L. Le Berre, P. Miqueu, N. Degauque, C. Ruiz, S. Brouard, M. Guillet, J. P. Soulillou and J. Dantal

      Version of Record online: 8 AUG 2006 | DOI: 10.1111/j.1600-6143.2006.01415.x

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      Although recurrence of idiopathic nephrotic syndrome has been ascribed to T cell activation, this study found no increase in T cell activation or specific clonal expansion associated with recurrence, compared to control patients.

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      Soluble HLA-G Expression and Renal Graft Acceptance (pages 2152–2156)

      J. Qiu, P. I. Terasaki, J. Miller, K. Mizutani, J. Cai and E. D. Carosella

      Version of Record online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01417.x

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      This study of 65 renal transplant patients found that soluble HLA-G was detectable in about 30%, and was negatively associated with allograft failure and production of HLA IgG antibodies, indicating an overall relationship between sHLA-G and favorable outcomes.

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      Predictors of Chronic Kidney Disease in Long-Term Survivors of Lung and Heart-Lung Transplantation (pages 2157–2163)

      M. Canales, P. Youssef, R. Spong, A. Ishani, K. Savik, M. Hertz and H. N. Ibrahim

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01458.x

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      In this cohort of lung and heart-lung transplant recipients surviving more than six months after transplantation, 55% doubled their serum creatinine and 7.3% progressed to end-stage renal disease, particularly those with the risk factors of older age, lower 1-month GFR, and cyclosporine use in the first six months.

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      Sirolimus Conversion for Patients with Posttransplant Kaposi's Sarcoma (pages 2164–2168)

      C. Lebbé, S. Euvrard, B. Barrou, C. Pouteil-Noble, J. L. Garnier, D. Glotz, C. Legendre and C. Francès

      Version of Record online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01412.x

      In 14 patients in France who developed post-transplant Kaposi's sarcoma and were switched to sirolimus, two had a complete remission, eight a partial response, and five had no significant improvement, but some partial responders later progressed.

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      Successful In Vitro Priming of EBV-Specific CD8+ T Cells Endowed with Strong Cytotoxic Function from T Cells of EBV-Seronegative Children (pages 2169–2176)

      P. Comoli, F. Ginevri, R. Maccario, C. Frasson, U. Valente, S. Basso, M. Labirio, G.-C. Huang, E. Verrina, F. Baldanti, F. Perfumo and F. Locatelli

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01429.x

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      In this in vitro study, EBV specific CD8+ cytotoxic T lymphocytes were generated from cells from EBV seronegative children.

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      Successful Liver Transplantation Following Medical Management of Portopulmonary Hypertension: A Single-Center Series (pages 2177–2182)

      N. Sussman, V. Kaza, N. Barshes, R. Stribling, J. Goss, C. O'Mahony, E. Zhang, J. Vierling and A. Frost

      Version of Record online: 22 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01432.x

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      Although severe portopulmonary hypertension has been regarded as an absolute contraindication to liver transplantation, these patients were treated with pulmonary vasodilators with responses and successful transplantation in some cases, suggesting that this may be a treatable condition in some people.

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      Impact of Dialysis and Older Age on Survival after Liver Transplantation (pages 2183–2190)

      E. S. Dellon, J. A. Galanko, R. K. Medapalli and M. W. Russo

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01454.x

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      With use of the MELD system for allocation of liver transplants, more patients are on dialysis prior to transplantation and more require liver-kidney transplants compared to the pre-MELD era.

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      Association of Clinical Risk Factors with Functional Status Following Lung Transplantation (pages 2191–2201)

      J. S. Sager, R. M. Kotloff, V. N. Ahya, D. Hadjiliadis, R. Simcox, N. P. Blumenthal, J. Mendez, W. B. Bilker, A. Pochettino and J. D. Christie

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01437.x

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      Recipient female gender, high BMI, and poor exercise performance before transplant were independently associated with poor exercise performance post-transplant, while cystic fibrosis and bilateral lung transplants were associated with better post-transplant exercise performance.

  4. Brief Communication

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Persistence of Antigen Is Required to Maintain Transplantation Tolerance Induced by Genetic Modification of Bone Marrow Stem Cells (pages 2202–2207)

      C. Tian, J. Bagley and J. Iacomini

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01455.x

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      When mice were induced to be tolerant by syngeneic bone marrow transduced with the gene for an alloantigen, depletion of the antigen-bearing cells also abrogated the tolerance, indicating that the mechanism of this effect requires persistence of antigen in the transfected cells.

  5. Case Reports

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Posttransplant Recurrence of Proteinuria in a Case of Focal Segmental Glomerulosclerosis Associated with WT1 Mutation (pages 2208–2211)

      G. M. Ghiggeri, F. Aucella, G. Caridi, L. Bisceglia, L. Ghio, M. Gigante, F. Perfumo, M. Carraro and L. Gesualdo

      Version of Record online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01418.x

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      Although previous cases of recurrent nephrotic syndrome have been described in inherited FSGS due to NPHS2 mutations, this case with WT1 mutation showed early onset of proteinuria associated with elevated plasma permeability activity, which responded to plasmapheresis.

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      Nephrogenic Systemic Fibrosis Among Liver Transplant Recipients: A Single Institution Experience and Topic Update (pages 2212–2217)

      M. Maloo, P. Abt, R. Kashyap, D. Younan, M. Zand, M. Orloff, A. Jain, A. Pentland, G. Scott and A. Bozorgzadeh

      Version of Record online: 19 JUN 2006 | DOI: 10.1111/j.1600-6143.2006.01420.x

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      These three cases developed nephrogenic systemic fibrosis within a few months after liver transplantation.

  6. Letters to the Editor

    1. Top of page
    2. Editorial
    3. Minireviews
    4. Original Articles:
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      BKV Replication and Cellular Immune Responses in Renal Transplant Recipients (pages 2218–2219)

      S. Binggeli, A. Egli, M. Dickenmann, I. Binet, J. Steiger and H. H. Hirsch

      Version of Record online: 6 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01460.x

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      Cyclosporine A Increases Plasma Concentrations and Effects of Repaglinide (pages 2221–2222)

      J. T. Backman, L. I. Kajosaari, M. Niemi and P. J. Neuvonen

      Version of Record online: 25 JUL 2006 | DOI: 10.1111/j.1600-6143.2006.01456.x

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