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American Journal of Transplantation

Cover image for Vol. 7 Issue 11

November 2007

Volume 7, Issue 11

Pages 2441–2646

  1. Editorial

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      Therapeutic Monitoring of Mycophenolic Acid: Is There Clinical Utility? (pages 2441–2442)

      P. West-Thielke and B. Kaplan

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01963.x

      Several studies have been done with mycophenolic acid drug monitoring. However, the critical utility still remains unclear. See also article by Le Meur et al in this issue on page 2496.

  2. Personal Viewpoint

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      The Challenging Triangle: Balancing Outcomes, Transplant Numbers and Costs (pages 2443–2445)

      Richard J. Howard

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01961.x

      Balancing three objectives of transplant centers, outcomes, transplant numbers and costs, can prove challenging, because improving results in one objective can lead to worse results in the other two.

  3. Special Feature

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      In Memoriam Mark B. Adams, M.D., M.S., F.A.C.S. (page 2446)

      C. Johnson, A. M. Roza and M. F. Levy

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01954.x

  4. Minireview

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      Platelets an Inflammatory Force in Transplantation (pages 2447–2454)

      C. N. Morrell, H. Sun, A. M. Swaim and W. M. Baldwin III

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01958.x

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      In addition to preserving vascular integrity, platelets modulate innate and adaptive immune responses that are relevant to transplant rejection.

  5. Original Articles:

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    1. Basic Science

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      Tacrolimus-Induced Diabetes in Rats Courses with Suppressed Insulin Gene Expression in Pancreatic Islets (pages 2455–2462)

      I. Hernández-Fisac, J. Pizarro-Delgado, C. Calle, M. Marques, A. Sánchez, A. Barrientos and J. Tamarit-Rodriguez

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01946.x

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      Insulin and pro-insulin mRNAs, as well as the secretory response to glucose were decreased in islets isolated from rats treated daily with tacrolimus.

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      Diannexin, a Novel Annexin V Homodimer, Protects Rat Liver Transplants Against Cold Ischemia-Reperfusion Injury (pages 2463–2471)

      X.-D. Shen, B. Ke, Y. Zhai, S.-I. Tsuchihashi, F. Gao, S. Duarte, A. Coito, R. W. Busuttil, A. C. Allison and J. W. Kupiec-Weglinski

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01967.x

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      Diannexin, a recombinant homodimer of human annexin V, decreases vascular inflammation and ischemiareperfusion injury in cold-stored rat livers orthotopically transplanted into syngeneic recipients.

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      Role of IFNγ in Allograft Tolerance Mediated by CD4+CD25+ Regulatory T Cells by Induction of IDO in Endothelial Cells (pages 2472–2482)

      P. Thebault, T. Condamine, M. Heslan, M. Hill, I. Bernard, A. Saoudi, R. Josien, I. Anegon, M. C. Cuturi and E. Chiffoleau

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01960.x

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      This study demonstrates that IFN-γ blockade abbrogates the transfer of allograft tolerance mediated by CD4+CD25+ regulatory T cells, by decreasing IDO expression in graft endothelial cells.

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      Transcriptome Analysis Reveals Heterogeneity in the Injury Response of Kidney Transplants (pages 2483–2495)

      K. S. Famulski, G. Broderick, G. Einecke, K. Hay, J. Cruz, B. Sis, M. Mengel and P. F. Halloran

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01980.x

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      This study of injury and repair-induced transcripts (IRITs) in mouse kidney transplants found multiple components, a systemic injury response, a local injury response in isografts, and an alloimmune amplification of the local injury response, which included reappearance of developmental genes.

    5. Clinical Science

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      Individualized Mycophenolate Mofetil Dosing Based on Drug Exposure Significantly Improves Patient Outcomes After Renal Transplantation (pages 2496–2503)

      Y. Le Meur, M. Büchler, A. Thierry, S. Caillard, F. Villemain, S. Lavaud, I. Etienne, P.-F. Westeel, B. H. De Ligny, L. Rostaing, E. Thervet, J. C. Szelag, J.-P. Rérolle, A. Rousseau, G. Touchard and P. Marquet

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01983.x

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      In this randomised trial comparing fixed dose versus therapeutic drug monitoring of MMF in kidney graft recipients, the concentration control group experienced less treatment failure and less rejection. See also editorial by West-Thielke and Kaplan in this issue on page 2441.

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      The Evolution of Nonimmune Histological Injury and Its Clinical Relevance in Adult-Sized Kidney Grafts in Pediatric Recipients (pages 2504–2514)

      M. Naesens, N. Kambham, W. Concepcion, O. Salvatierra Jr and M. Sarwal

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01949.x

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      This protocol biopsy study demonstrates progressive, functionally relevant, non-immune injury after adult-sized kidney transplantation in pediatric recipients, associated with renal graft ischemia associated with the donor-recipient size discrepancy.

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      Low-Turnover Bone Disease in Hypercalcemic Hyperparathyroidism After Kidney Transplantation (pages 2515–2521)

      K. Borchhardt, I. Sulzbacher, T. Benesch, M. Födinger, G. Sunder-Plassmann and M. Haas

      Version of Record online: 24 AUG 2007 | DOI: 10.1111/j.1600-6143.2007.01950.x

      A considerable number of kidney transplant recipients with hypercalcemic hyperparathyroidism have decreased bone turnover, which makes the general indication of parathyroidectomy in these patients questionable.

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      Sirolimus Versus Cyclosporine in Kidney Recipients Receiving Thymoglobulin®, Mycophenolate Mofetil and a 6-Month Course of Steroids (pages 2522–2531)

      M. Büchler, S. Caillard, S. Barbier, E. Thervet, O. Toupance, H. Mazouz, B. Hurault de Ligny, Y. Le Meur, A. Thierry, F. Villemain, A.-E. Heng, B. Moulin, M. P. Morin, C. Noël, Y. Lebranchu and SPIESSER Group

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01976.x

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      In this 12-month randomized, multicenter study including 145 de novo renal transplant recipients, a calcineurin inhibitor-free regimen using sirolimus-MMF was as effective as a cyclosporine-based regimen in terms of survival, rejection, and renal function.

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      2509 Living Donor Nephrectomies, Morbidity and Mortality, Including the UK Introduction of Laparoscopic Donor Surgery (pages 2532–2537)

      V. G. Hadjianastassiou, R. J. Johnson, C. J. Rudge and N. Mamode

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01975.x

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      While the expansion of the laparoscopic at the expense of the open donor nephrectomy has been based on faster convalescence for the donor, the UK Transplant National Registry documents that laparoscopic donation is also a safer procedure for the donor.

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      Lack of Benefit of Early Protocol Biopsies in Renal Transplant Patients Receiving TAC and MMF: A Randomized Study (pages 2538–2545)

      D. Rush, D. Arlen, A. Boucher, S. Busque, S. M. Cockfield, C. Girardin, G. Knoll, J.-G. Lachance, D. Landsberg, J. Shapiro, A. Shoker and S. Yilmaz

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01979.x

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      This randomized study shows that early protocol biopsies do not improve the short term outcome of renal transplant patients of low immunological risk treated with TAC/MMF and prednisone, likely because of their low prevalence of subclinical acute rejection.

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      Vitamin D Status in Renal Transplant Recipients (pages 2546–2552)

      A. Stavroulopoulos, M. J. D. Cassidy, C. J. Porter, D. J. Hosking and S. D. Roe

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01978.x

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      Vitamin D status is low in virtually all the renal transplant recipients in a study in central England, and may aggravate the secondary hyperparathyroidism, but its correction is difficult in patients with hypercalcemia.

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      Hyperlipidemia Is Associated With Accelerated Chronic Kidney Disease Progression After Lung Transplantation (pages 2553–2560)

      B. R. Stephany, B. Alao, M. Budev, M. Boumitri and E. D. Poggio

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01968.x

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      Lung transplant recipients with higher lipid levels early post-transplant experienced a faster decline in kidney function independent of other factors, typically associated with chronic kidney disease.

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      Medication Errors: An Important Component of Nonadherence to Medication in an Outpatient Population of Lung Transplant Recipients (pages 2561–2566)

      S. Irani, P. Seba, R. Speich and A. Boehler

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01962.x

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      By direct observation the concordance between the flow sheet, the patient's diary card and the pill container was investigated in lung transplant recipients, compared with clinical adverse events.

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      Immunogenicity and Safety of an Intradermal Boosting Strategy for Vaccination Against Influenza in Lung Transplant Recipients (pages 2567–2572)

      O. Manuel, A. Humar, M. H. Chen, S. Chernenko, L. G. Singer, I. Cobos and D. Kumar

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01982.x

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      In a cohort of 60 lung transplant recipients, a booster dose of seasonal influenza vaccine delivered intradermally does not significantly boost the immunogenicity of the standard intramuscular dose.

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      Plasma Intercellular Adhesion Molecule-1 and von Willebrand Factor in Primary Graft Dysfunction After Lung Transplantation (pages 2573–2578)

      M. Covarrubias, L. B. Ware, S. M. Kawut, J. De Andrade, A. Milstone, A. Weinacker, J. Orens, V. Lama, K. Wille, S. Bellamy, C. Shah, E. Demissie, J. D. Christie and for the Lung Transplant Outcomes Group

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01981.x

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      A prospective multicenter study of 128 lung transplant recipients found that elevated levels of plasma ICAM-1 were associated with primary graft dysfunction, independent of all clinical variables except pulmonary artery pressures prior to transplant.

      Corrected by:

      Erratum

      Vol. 8, Issue 2, 469–470, Version of Record online: 15 JAN 2008

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      Bloodstream Infections Among Transplant Recipients: Results of a Nationwide Surveillance in Spain (pages 2579–2586)

      A. Moreno, C. Cervera, J. Gavaldá, M. Rovira, R. De La Cámara, I. Jarque, M. Montejo, J. De La Torre-Cisneros, J. Miguel Cisneros, J. Fortún, F. López-Medrano, M. Gurguí, P. Muñoz, A. Ramos and J. Carratalá

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01964.x

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      Bloodstream infections in transplant recipients still represent a challenge, especially for the emergence of multiresistant bacteria and fungi.

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      Liver Transplantation for Hepatocellular Carcinoma: Validation of the UCSF-Expanded Criteria Based on Preoperative Imaging (pages 2587–2596)

      F. Y. Yao, L. Xiao, N. M. Bass, R. Kerlan, N. L. Ascher and J. P. Roberts

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01965.x

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      The UCSF criteria for hepatocellular carcinoma applied as selection criteria for liver transplantation based on pre-operative imaging are associated with excellent post-transplant survival, without a higher risk of tumor recurrence or under-staging than the Milan criteria.

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      Liver Transplantation for Familial Amyloidotic Polyneuropathy (FAP): A Single-Center Experience Over 16 Years (pages 2597–2604)

      S. Yamamoto, H. E. Wilczek, G. Nowak, M. Larsson, A. Oksanen, T. Iwata, H. Gjertsen, G. Söderdahl, L. Wikström, Y. Ando, O. B. Suhr and B.-G. Ericzon

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01969.x

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      This review of 86 FAP patients undergoing liver transplantation, found that the majority experienced an arrest of symptom progression, but only a minority experienced an improvement, suggesting that liver transplantation should be performed early in the course of the disease.

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      Synergistic Deposition of C4d by Complement-Activating and Non-activating Antibodies in Cardiac Transplants (pages 2605–2614)

      K. Murata, K. Fox-Talbot, Z. Qian, K. Takahashi, G. L. Stahl, W. M. Baldwin III and B. A. Wasowska

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01971.x

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      Employing in vivo and in vitro models and a newly developed antibody to mouse C4d, this study demonstrates a novel contribution of the MBL pathway and non-complement-activating antibodies to the pathology of antibody-mediated cardiac allograft rejection.

  6. Brief Communications

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    1. You have free access to this content
      Reuse of Auxiliary Liver Grafts in Second Recipients With Chronic Liver Disease (pages 2615–2618)

      J. Ringers, J. Dubbeld, A. G. Baranski, M. Coenraad, E. Sarton, A. F. M. Schaapherder and B. Van Hoek

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01959.x

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      Two hypertrophied partial liver grafts, previously used to bridge acute liver failure, one with renoportal anastomosis, were re-used for orthotopic liver transplantation in second recipients with chronic liver failure.

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      Dissociation of Depletional Induction and Posttransplant Lymphoproliferative Disease in Kidney Recipients Treated With Alemtuzumab (pages 2619–2625)

      A. D. Kirk, W. S. Cherikh, M. Ring, G. Burke, D. Kaufman, S. J. Knechtle, S. Potdar, R. Shapiro, V. R. Dharnidharka and H. M. Kauffman

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01972.x

      An evaluation of the UNOS database examining induction strategies following renal transplantation found that alemtuzumab induction, unlike other forms of depletional induction, was not associated with a significant increase in the risk of PTLD, and that sirolimus based therapies were unexpectedly found to increase the risk of PTLD.

  7. Case Reports

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      Domino Heart Transplantation Involving Infants (pages 2626–2629)

      T. L. Astor, M. Galantowicz, A. Phillips, J. T. Davis and T. M. Hoffman

      Version of Record online: 24 AUG 2007 | DOI: 10.1111/j.1600-6143.2007.01948.x

      This article reports successful domino heart transplantation involving the youngest donor and recipient ever recorded, and describes the echocardiographic and cardiac catheterization findings in the domino heart during the first year post-transplant.

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      Orthotopic Ileal Neobladder Reconstruction after Renal Transplant (pages 2630–2633)

      T. Cooke, M. M. Soloway and M. Manoharan

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01951.x

      Orthotopic ileal neobladder after renal transplant is a safe and feasible option after radical cystectomy.

      Corrected by:

      Erratum

      Vol. 8, Issue 2, 468, Version of Record online: 15 JAN 2008

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      Disappearance of Tophi in Familial Juvenile Hyperuricemic Nephropathy after Kidney Transplantation (pages 2634–2636)

      E. Merieau, A. Al Najjar, J.-M. Halimi, M. Sacquépée, H. Nivet, Y. Lebranchu and M. Büchler*

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01977.x

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      Renal transplantation in a patient with multiple tophi due to FJHN with a mutation of the UMOD gene was followed by regression of the tophi within 6 months post-transplantation.

  8. Letters to the Editor

    1. Top of page
    2. Editorial
    3. Personal Viewpoint
    4. Special Feature
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
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      No Evidence for a Relationship Between Infiltrates in Renal Protocol Biopsies and Outcome (pages 2637–2638)

      Klemens Budde, Lutz Liefeldt, Torsten Slowinski and Petra Glander

      Version of Record online: 7 AUG 2007 | DOI: 10.1111/j.1600-6143.2007.01920.x

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      Realities in Organ Donation (pages 2641–2642)

      R. Matesanz, E. Coll and G. Garrido

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01953.x

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      Realities in Organ Donation: Reply (pages 2643–2644)

      L. Roels, B. Cohen and C. Gachet

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01989.x

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      Cyclosporine Abrogates De Novo Generation of Tregs Independently of IL-2 (page 2645)

      J. Zuber, A. Brodin-Sartorius, E. Thervet and C. Legendre

      Version of Record online: 9 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01970.x

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