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American Journal of Transplantation

Cover image for Vol. 7 Issue 12

December 2007

Volume 7, Issue 12

Pages 2647–2837

  1. Editorials

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    1. You have free access to this content
      Medication Compliance in Transplantation (pages 2647–2649)

      Kevin Abbott

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01992.x

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      Assessing medication compliance after kidney transplantation sounds simple, but in practice turns out to be quite complex, especially using observational data. See also article by Takemoto et al in this issue on page 2704.

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      Getting Out of Flatland: Into the Third Dimension of Microarrays (pages 2650–2651)

      R. B. Colvin

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02024.x

      The analysis of microarrays using pathogenesis-based transcript sets provides an opportunity to expand the frontiers of transplant pathology into a new dimension in which mechanisms and pathways can be linked to lesions. See also article by Mueller et al in this issue on page 2712.

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      Enhancing Transplant Safety: A New Era in the Microbiologic Evaluation of Organ Donors? (pages 2652–2654)

      J. A. Fishman, M. A. Greenwald and M. J. Kuehnert

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02023.x

      Transmission of infectious diseases via allograft transplantation remains uncommon. Enhanced microbiological screening of organ donors and improved and open reporting of possible transmission events will enhance the safety of organ and tissue transplantation. See also article by Yao et al in this issue on page 2723.

  2. Special Feature

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
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      TRIBUTE: Professor R. Küss, 1913–2006 (pages 2655–2656)

      Prof. B. Charpentier

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02002.x

      Rene Küss was a larger than life figure in the world of transplantation, and his contributions, including his invention of the universally used renal transplantation technique will long be remembered.

  3. Minireview

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      Renal Transplantation in the ANCA-Associated Vasculitides (pages 2657–2662)

      D. Geetha and P. Seo

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01988.x

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      This review summarizes our current knowledge of indications and contraindications for renal transplantation in patients with ANCA associated vasculitis who have end stage renal disease, the recurrence of vasculitis after transplantation, and the impact of post transplant immunosuppression on the clinical course of these patients.

  4. Original Articles

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    1. Basic Science

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      Combined Coinhibitory and Costimulatory Modulation with Anti-BTLA and CTLA4Ig Facilitates Tolerance in Murine Islet Allografts (pages 2663–2674)

      W. Truong, J. C. Plester, W. W. Hancock, S. Merani, T. L. Murphy, K. M. Murphy, J. Kaye, C. C. Anderson and A. M. J. Shapiro

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01996.x

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      Targeting the BTLA coinhibitory pathway in conjunction with CTLA4Ig costimulatory blockade significantly prolongs murine islet allograft survival by promoting donor-specific tolerance.

      Corrected by:

      Erratum

      Vol. 8, Issue 2, 471, Article first published online: 15 JAN 2008

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      Macrophage Depletion Suppresses Cardiac Allograft Vasculopathy in Mice (pages 2675–2682)

      W. H. Kitchens, C. M. Chase, S. Uehara, L. D. Cornell, R. B. Colvin, P. S. Russell and J. C. Madsen

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01997.x

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      Depleting host macrophages with carageenen can suppress the development of cardiac allograft vasculopathy in F1 recipients of a parental allograft.

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      Striking Dichotomy of PD-L1 and PD-L2 Pathways in Regulating Alloreactive CD4+ and CD8+ T Cells In Vivo (pages 2683–2692)

      A. Habicht, R. Kewalaramani, M. D. Vu, G. Demirci, B. R. Blazar, M. H. Sayegh and X. C. Li

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01999.x

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      This paper showed that PD-L1 and PD-L2 act differently in regulating alloreactive T cells in vivo, since blocking PD-L2 enhanced in vivo proliferation of CD8+ T cells but inhibited CD4+ T cell proliferation, suggesting that the inhibitory effect of PD-1 engagement is not uniform to all T cell subsets in all models.

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      Clinically Relevant Immunosuppressants Influence UVB-Induced Tumor Size Through Effects on Inflammation and Angiogenesis (pages 2693–2703)

      F J. Duncan, Brian C. Wulff, Kathleen L. Tober, Amy K. Ferketich, Jason Martin, Jennifer M. Thomas-Ahner, Stephanie D. Allen, Donna F. Kusewitt, Tatiana M. Oberyszyn and Anne M. VanBuskirk

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02004.x

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      Some of the effects of immunosuppressive drugs on UVB-induced tumor size may operate by enhancing inflammation and tumor blood vessel density, which were promoted by cyclosporine but inhibited by mycophenolate (inflammation) or sirolimus (vascularity).

    5. Clinical Science

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      A Retrospective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipients (pages 2704–2711)

      S. K. Takemoto, B. W. Pinsky, M. A. Schnitzler, K. L. Lentine, L. M. Willoughby, T. E. Burroughs and S. Bunnapradist

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01966.x

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      Poor immunosuppression compliance as measured using the frequency of prescription filling was associated with increased risk of kidney allograft loss. See also editorial by Abbott in this issue on page 2647.

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      Microarray Analysis of Rejection in Human Kidney Transplants Using Pathogenesis-Based Transcript Sets (pages 2712–2722)

      T. F. Mueller, G. Einecke, J. Reeve, B. Sis, M. Mengel, G. S. Jhangri, S. Bunnag, J. Cruz, D. Wishart, C. Meng, G. Broderick, B. Kaplan and P. F. Halloran

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02005.x

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      This study explored GeneChip® technology as a diagnostic tool for kidney transplant rejection, showing that pathogenesis-based transcript sets correlated with histopathologic lesions and were highest in biopsies with clinically apparent rejection episodes. See also editorial by Colvin in this issue on page 2650.

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      The Risk of HIV, HBV, HCV and HTLV Infection Among Musculoskeletal Tissue Donors in Australia (pages 2723–2726)

      F. Yao, C. Seed, A. Farrugia, D. Morgan, S. Cordner, D. Wood and M. H. Zheng

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02012.x

      The risk of viral transmission although low, are higher among Australian musculoskeletal tissue donors than among first-time blood donors. See also editorial by Fishman et al in this issue on page 2652.

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      Prospective Monitoring of Polyomavirus BK Replication and Impact of Pre-Emptive Intervention in Pediatric Kidney Recipients (pages 2727–2735)

      F. Ginevri, A. Azzi, H. H. Hirsch, S. Basso, I. Fontana, M. Cioni, S. Bodaghi, V. Salotti, A. Rinieri, G. Botti, F. Perfumo, F. Locatelli and P. Comoli

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01984.x

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      This prospective study conducted in 62 pediatric kidney transplant recipients shows that pre-emptive reduction of immunosuppression in patients with BKV reactivation allows for viral clearance and prevention of BKV-associated nephropathy through reconstitution of virus specific immunity, without increased incidence of acute rejection.

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      Alemtuzumab Pre-Conditioning With Tacrolimus Monotherapy in Pediatric Renal Transplantation (pages 2736–2738)

      R. Shapiro, D. Ellis, H. P. Tan, M. L. Moritz, A. Basu, A. N. Vats, L. K. Kayler, E. Erkan, C. G. McFeaters, G. James, M. J. Grosso, A. Zeevi, E. A. Gray, A. Marcos and T. E. Starzl

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01987.x

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      An immunosuppressive regimen of alemtuzumab preconditioning with tacrolimus monotherapy and subsequent spaced weaning may be effective in pediatric renal transplant recipients.

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      Immunephenotype of Glomerular and Interstitial Infiltrating Cells in Protocol Renal Allograft Biopsies and Histological Diagnosis (pages 2739–2747)

      F. Moreso, D. Seron, F. O'Valle, M. Ibernon, M. Gomà, M. Hueso, J. M. Cruzado, O. Bestard, V. Duarte, R. García del Moral and J. M. Grinyó

      Article first published online: 19 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02013.x

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      In protocol biopsies of kidney transplant recipients, B cell infiltrates were associated with IF/TA, but whether these infiltrates were the cause or the consequence of tubular interstitial damage is not clear.

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      Proteinuria After Kidney Transplantation, Relationship to Allograft Histology and Survival (pages 2748–2756)

      H. Amer, M. E. Fidler, M. Myslak, P. Morales, W. K. Kremers, T. S. Larson, M. D. Stegall and F. G. Cosio

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02006.x

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      This study of the association between proteinuria and kidney pathology in surveillance graft biopsies showed that even low levels of proteinuria are associated with reduced graft survival, while kidney prognosis is worsens progressively as the level of proteinuria increases, independent of any other variable tested, including graft histology.

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      Transplant Glomerulopathy: Ultrastructural Abnormalities Occur Early in Longitudinal Analysis of Protocol Biopsies (pages 2757–2768)

      M. D. Wavamunno, P. J. O'Connell, M. Vitalone, C. L.-S. Fung, R. D. M. Allen, J. R. Chapman and B. J. Nankivell

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01995.x

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      Ultrastructural changes in transplant glomerulopathy occurred early in protocol biopsies in association with C4d deposition, presence of donor specific antibody and prior to detection by light microscopy or diagnosis of graft dysfunction.

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      Outcome of Kidney Transplantation Using Expanded Criteria Donors and Donation After Cardiac Death Kidneys: Realities and Costs (pages 2769–2774)

      R. F. Saidi, N. Elias, T. Kawai, M. Hertl, M.-L. Farrell, N. Goes, W. Wong, C. Hartono, J. A. Fishman, C. N. Kotton, N. Tolkoff-Rubin, F. L. Delmonico, A. B. Cosimi and D. S. C. Ko

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01993.x

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      Utilization of ECD and DCD kidneys is associated with increase in cost and resource utilization.

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      Respective Predictive Role of Urinary Albumin Excretion and Nonalbumin Proteinuria on Graft Loss and Death in Renal Transplant Recipients (pages 2775–2781)

      Jean-Michel Halimi, Buchler Matthias, Azmi Al-Najjar, Inass Laouad, Valérie Chatelet, Jean-Frédéric Marlière, Hubert Nivet and Yvon Lebranchu

      Article first published online: 19 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02010.x

      Proteinuria is made of various proportions of urinary albumin excretion and non-albumin proteinuria which provide different information on graft/patient survival in renal transplantation.

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      Efficacy of Living Donor Liver Transplantation for Patients With Methylmalonic Acidemia (pages 2782–2787)

      D. Morioka, M. Kasahara, R. Horikawa, S. Yokoyama, A. Fukuda and A. Nakagawa

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01986.x

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      Living donor transplantation provides satisfactory quality of life to patients with methylmalonic acidemia.

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      The Ischemic Preconditioning Paradox in Deceased Donor Liver Transplantation—Evidence from a Prospective Randomized Single Blind Clinical Trial (pages 2788–2796)

      B. Koneru, A Shareef, G. Dikdan, K. Desai, K. M. Klein, B. Peng, R. H. Wachsberg, A. N. De La Torre, M. Debroy, A. Fisher, D. J. Wilson and A. K. Samanta

      Article first published online: 19 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02009.x

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      Ischemic preconditioning of the liver caused a paradoxical increase in early post-transplant AST/ALT but resulted in increased plasma IL-10 levels along with a trend towards fewer moderate/severe rejections.

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      Comparison of Quantiferon-TB Gold With Tuberculin Skin Test for Detecting Latent Tuberculosis Infection Prior to Liver Transplantation (pages 2797–2801)

      O. Manuel, A. Humar, J. Preiksaitis, K. Doucette, S. Shokoples, A. Y. Peleg, I. Cobos and D. Kumar

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02011.x

      The Quantiferon-Gold In-Tube assay was comparable to the tuberculin skin test for the diagnosis of latent tuberculosis infection in liver transplant candidates.

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      Alemtuzumab in the Treatment of Refractory Acute Rejection and Bronchiolitis Obliterans Syndrome After Human Lung Transplantation (pages 2802–2808)

      B. D. Reams, L. W. Musselwhite, D. W. Zaas, M. P. Steele, S. Garantziotis, P. C. Eu, L. D. Snyder, J. Curl, S. S. Lin, R. D. Davis and S. M. Palmer

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02000.x

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      In lung transplant recipients with refractory acute rejection or early bronchiolitis obliterans syndrome, alemtuzumab administered with strict infection prophylaxis reverses rejection or stabilizes lung function in a majority of patients.

  5. Brief Communications

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      C4d Fixing, Luminex Binding Antibodies—A New Tool for Prediction of Graft Failure After Heart Transplantation (pages 2809–2815)

      J. D. Smith, I. M. Hamour, N. R. Banner and M. L. Rose

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01991.x

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      In this retrospective study of pre-transplant serum from 565 patients, the presence of C4d fixing donor specific antibodies, detected by Luminex, is shown to be a powerful negative predictor of graft failure.

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      Immunosuppressant Pharmacokinetics and Dosing Modifications in HIV-1 Infected Liver and Kidney Transplant Recipients (pages 2816–2820)

      L. A. Frassetto, M. Browne, A. Cheng, A. R. Wolfe, M. E. Roland, P. G. Stock, L. Carlson and L. Z. Benet

      Article first published online: 19 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02007.x

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      Pharmacokinetics and initial dosing of immunosuppressants in HIV-infected liver and kidney transplant patients on various antiretroviral regimens.

  6. Case Reports

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
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      Successful Induction of Remission With Rituximab for Relapse of ANCA-Associated Vasculitis Post-Kidney Transplant: Report of Two Cases (pages 2821–2825)

      D. Geetha, P. Seo, U. Specks and F. C. Fervenza

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01985.x

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      Rituximab treatment was associated with remission in two cases of recurrent ANCA associated vasculitis post kidney transplant.

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      Cellulitis Revealing a Cryptococcosis-Related Immune Reconstitution Inflammatory Syndrome in a Renal Allograft Recipient (pages 2826–2828)

      F. Lanternier, M.-O. Chandesris, S. Poirée, M.-E. Bougnoux, F. Mechai, M.-F. Mamzer-Bruneel, J.-P. Viard, L. Galmiche-Rolland, M. Lecuit and O. Lortholary

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01994.x

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      This renal transplant recipient developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy and required the administration of a short-term steroid therapy to resolve.

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      Anderson-Fabry Disease in Kidneys from Deceased Donor (pages 2829–2833)

      N. Basic-Jukic, M. Coric, P. Kes, L. J. Bubic-Filipi, J. Pasini and I. Mokos

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02003.x

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      Excellent graft function was achieved after renal transplantation from deceased donor with Fabry disease.

  7. Letters to the Editor

    1. Top of page
    2. Editorials
    3. Special Feature
    4. Minireview
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    8. Letters to the Editor
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    2. You have free access to this content
      Renal Allograft Rejection: Difficulties in Biopsy Diagnosis in Low-Income Countries (page 2835)

      L. F. Arias, A. A. Arteta and R. D. Giraldo

      Article first published online: 30 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.01952.x

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      Inferior Vena Cava Thrombosis After Right Hepatectomy for Live Donor Liver Transplantation: A Major Donor Complication and a Satisfactory Treatment Modality (pages 2836–2837)

      G. C. Sotiropoulos, I. Fouzas, A. Paul, S. Nadalin, E. P. Molmenti, C. Valentin-Gamazo, A. Radtke, H. Kühl, M. Malagó and C. E. Broelsch

      Article first published online: 19 OCT 2007 | DOI: 10.1111/j.1600-6143.2007.02008.x

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