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American Journal of Transplantation

Cover image for Vol. 7 Issue 2

February 2007

Volume 7, Issue 2

Pages 267–486

  1. Editorials

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      Eye of the Needle (pages 267–268)

      R. B. Colvin

      Article first published online: 15 NOV 2006 | DOI: 10.1111/j.1600-6143.2006.01609.x

      At present, protocol biopsies offer potential for early detection of pathologic processes in the graft, but like any test their predictive value must be established and validated. See also article by Mengel et al in this issue on page 356.

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      Improving Patient Education Delivery to Increase Living Donation Rates (pages 269–270)

      A. D. Waterman and D. C. Brennan

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01652.x

      Living donation educational programs that include the entire family and address psychological and practical issues may increase the number of living donor transplants. See also article by Rodrigue et al in this issue on page 394.

  2. Minireviews

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      Epstein-Barr Virus: Evasive Maneuvers in the Development of PTLD (pages 271–277)

      Andrew L. Snow and Olivia M. Martinez

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01650.x

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      EBV has evolved a complex relationship with the host immune system that may be relevant to the development of PTLD, including production of viral IL-10, soluble CSF receptor, and apoptosis resistance, all of which may have therapeutic implications.

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      The Interleukin-12 Family: New Players in Transplantation Immunity? (pages 278–284)

      S. Goriely and M. Goldman

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01651.x

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      The IL-12 family - IL-12p70, IL-23, and IL-27 - has the potential for major effects in alloimmunity through interferon-gamma and IL-17 and their effects on the immune response and inflammation.

  3. Meeting Report

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      American Society of Transplantation Executive Summary on Pediatric Lung Transplantation (pages 285–292)

      A. Faro, G. B. Mallory, G. A. Visner, O. Elidemir, P. J. Mogayzel Jr, L. Danziger-Isakov, M. Michaels, S. Sweet, P. Michelson, S. Paranjape, C. Conrad and D. A. Waltz

      Article first published online: 15 NOV 2006 | DOI: 10.1111/j.1600-6143.2006.01612.x

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      This summary reviews the available data in pediatric lung transplantation and highlights current deficiencies in knowledge in the hopes of ultimately stimulating additional work in the field and improving long term outcomes.

  4. Original Articles

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. Basic Science

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      Blockade of RAGE Suppresses Alloimmune Reactions In Vitro and Delays Allograft Rejection in Murine Heart Transplantation (pages 293–302)

      B. Moser, M. J. Szabolcs, H. J. Ankersmit, Y. Lu, W. Qu, A. Weinberg, K. C. Herold and A. M. Schmidt

      Article first published online: 18 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01617.x

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      Employing an in vivo model of fully MHC-mismatched cardiac transplantation and murine and human mixed lymphocyte reaction studies, this study demonstrates that pharmacologic blockade of RAGE prolongs mouse heart allograft survival.

      Corrected by:

      Erratum

      Vol. 7, Issue 5, 1318, Article first published online: 23 APR 2007

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      Simple Measures to Monitor β-Cell Mass and Assess Islet Graft Dysfunction (pages 303–308)

      R. N. Faradji, K. Monroy, S. Messinger, A. Pileggi, T. Froud, D. A. Baidal, P. E. Cure, C. Ricordi, L. Luzi and R. Alejandro

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01620.x

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      The C-peptide-glucose ratio correlates with mass of transplanted islets, and is more indicative of graft dysfunction than C-peptide alone and thus can complement the post-transplant monitoring of recipients of allogeneic islets.

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      Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation (pages 309–319)

      M. Martínez-Llordella, I Puig-Pey, G. Orlando, M. Ramoni, G. Tisone, A. Rimola, J. Lerut, D. Latinne, C. Margarit, I. Bilbao, S. Brouard, M. Hernández-Fuentes, J. -P. Soulillou and A. Sánchez-Fueyo

      Article first published online: 18 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01621.x

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      Microarray profiling of peripheral blood on 16 operationally tolerant liver recipients identified some candidate features that could identify patients in which drug weaning is more likely to be successful.

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      Induction of Chimerism in Rhesus Macaques through Stem Cell Transplant and Costimulation Blockade-Based Immunosuppression (pages 320–335)

      L. S. Kean, A. B. Adams, E. Strobert, R. Hendrix, S. Gangappa, T. R. Jones, N. Shirasugi, M. R. Rigby, K. Hamby, J. Jiang, H. Bello, D. Anderson, K. Cardona, M. M. Durham, T. C. Pearson and C. P. Larsen

      Article first published online: 18 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01622.x

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      A strategy of stem cell transplantation plus busulphan, IL-2 receptor blockade, sirolimus, and combined CD28/CD154 costimulation blockade induced donor cell chimerism for a median of 145 days, but viral reactivation constituted a significant toxicity.

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      Mesenchymal Stem Cells Facilitate the Induction of Mixed Hematopoietic Chimerism and Islet Allograft Tolerance without GVHD in the Rat (pages 336–346)

      S. Itakura, S. Asari, J. Rawson, T. Ito, I. Todorov, C.-P. Liu, N. Sasaki, F. Kandeel and Y. Mullen

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01643.x

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      Donor mesenchymal stem cells (MSCs) co-infused with donor bone marrow cells and islets into the portal vein of diabetic rats treated with non-myeloablative recipient conditioning regimen helped to induce mixed hematopoietic chimerism and subsequent acceptance of islet allografts.

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      Rho-Associated Kinase Inhibitor Reduces Tumor Recurrence After Liver Transplantation in a Rat Hepatoma Model (pages 347–355)

      T. Ogawa, H. Tashiro, Y. Miyata, Y. Ushitora, Y. Fudaba, T. Kobayashi, K. Arihiro, M. Okajima and T. Asahara

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01647.x

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      Tacrolimus stimulates the Rho/ROCK signal pathway to enhance the invasiveness of hepatocellular carcinoma, and the ROCK inhibitor Y-27632 can prevent tumor recurrence after liver transplantation in rat hepatocellular carcinoma.

    7. Clinical Science

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      Infiltrates in Protocol Biopsies from Renal Allografts (pages 356–365)

      M. Mengel, W. Gwinner, A. Schwarz, R. Bajeski, I. Franz, V. Bröcker, T. Becker, M. Neipp, J. Klempnauer, H. Haller and H. Kreipe

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01635.x

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      In 803 protocol biopsies compared to 306 biopsies for cause, the protocol biopsies had a lower frequency of diffuse cortical infiltrates, but the only predictor of allograft function outcome was persistent inflammation in all sequential biopsies, irrespective of type, location, and composition of the cellular infiltrates. See also editorial by Colvin in this issue on page 267.

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      Mycophenolate Mofetil Is Associated with Altered Expression of Chronic Renal Transplant Histology (pages 366–376)

      B. J. Nankivell, M. D. Wavamunno, R. J. Borrows, M. Vitalone, C. L-S Fung, R. D. M. Allen, J. R. Chapman and P. J. O'Connell

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01633.x

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      Comparison of protocol kidney biopsies in two patients treated with cyclosporine plus either mycophenolate or azathioprine revealed decreased fibrosis and glomerulopathy, and a reduction in features associated with cyclosporine nephrotoxicity, suggesting that MMF limits immune-mediated injury and may directly reduce fibrosis.

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      Lymphatic Neoangiogenesis in Human Renal Allografts: Results from Sequential Protocol Biopsies (pages 377–384)

      S. Stuht, W. Gwinner, I. Franz, A. Schwarz, D. Jonigk, H. Kreipe, D. Kerjaschki, H. Haller and M. Mengel

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01638.x

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      This study of 162 sequential protocol biopsies in kidney transplant recipients demonstrated an association between lymphatic neoangiogenesis and cellular infiltrates, with better function being associated with infiltrates having lymph vessels than those that did not have lymph vessels.

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      The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries (pages 385–393)

      T. Fahim, G. A. Böhmig, M. Exner, N. Huttary, H. Kerschner, S. Kandutsch, D. Kerjaschki, A. Bramböck, K. Nagy-Bojarszky and H. Regele

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01634.x

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      Studies of transplant biopsies from kidneys with antibody-mediated rejection revealed an excessive number of CD68+ monocytes within glomerular and peritubular capillaries, manifested by an elevated monocyte/T cell ratio in peritubular capillaries.

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      Increasing Live Donor Kidney Transplantation: A Randomized Controlled Trial of a Home-Based Educational Intervention (pages 394–401)

      J. R. Rodrigue, D. L. Cornell, J. K. Lin, B. Kaplan and R. J. Howard

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01623.x

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      In this randomized controlled trial, patients who received standard care plus a home-based live donation educational program had more living donor inquiries, living donor evaluations, and live donor kidney transplants than patients randomized to receive standard clinic-based education alone. See also editorial by Waterman and Brennan in this issue on page 269.

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      The Effect of Desensitization Protocols on Human Splenic B-Cell Populations In Vivo (pages 402–407)

      E. J. Ramos, H. S. Pollinger, M. D. Stegall, J. M. Gloor, A. Dogan and J. P. Grande

      Article first published online: 18 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01632.x

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      An immunohistologic study of spleens taken after desensitization protocols (plasmapheresis/ low dose IVIG/ rituximab) in renal allograft recipients revealed a differential impact on human splenic B cell subsets, but no change in splenic plasma cell numbers.

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      Four-year Follow-up of a Prospective Trial of HLA and MICA Antibodies on Kidney Graft Survival (pages 408–415)

      P. I. Terasaki, M. Ozawa and R. Castro

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01644.x

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      Two studies of functioning kidney transplants reported here demonstrate that patients with MICA antibodies, as well as those with HLA antibodies, have an increased risk of graft failure.

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      Obesity, Adiponectin and Inflammation as Predictors of New-Onset Diabetes Mellitus After Kidney Transplantation (pages 416–422)

      B. Bayés, M.L. Granada, M.C. Pastor, R. Lauzurica, I. Salinas, A. Sanmartí, A. Espinal, A. Serra, M. Navarro, J. Bonal and R. Romero

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01646.x

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      This analysis of non-diabetic kidney transplant recipients found that serum adiponectin levels were an independent predictor of new onset diabetes after transplantation, with high levels associated with reduced risk.

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      Heightened Expression of the Cytotoxicity Receptor NKG2D Correlates with Acute and Chronic Nephropathy After Kidney Transplantation (pages 423–433)

      M. Seiler, I. Brabcova, O. Viklicky, P. Hribova, C. Rosenberger, J. Pratschke, A. Lodererova, M. Matz, C. Schönemann, P. Reinke, H.-D. Volk and K. Kotsch

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01625.x

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      The activating natural cytotoxicity receptor NKG2D could be detected at both mRNA and protein level in biopsies diagnosed with acute and chronic nephropathy.

      Corrected by:

      Erratum

      Vol. 7, Issue 7, 1873, Article first published online: 26 MAY 2007

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      Efficacy of a Pre-S Containing Vaccine in Patients Receiving Lamivudine Prophylaxis after Liver Transplantation for Chronic Hepatitis B (pages 434–439)

      C.-M. Lo, G. K. Lau, S.-C. Chan, S.-T. Fan and J. Wong

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01636.x

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      In 20 liver transplant recipients on lamivudine prophylaxis because of risk of HBV reinfection, immunization with a pre-S containing vaccine induced antibody responses in 50%, raising the possibility that this strategy may prevent recurrence due to escaped mutants.

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      Living-Related Versus Deceased Donor Pediatric Liver Transplantation: A Multivariate Analysis of Technical and Immunological Complications in 235 Recipients (pages 440–447)

      C. Bourdeaux, A. Darwish, J. Jamart, T.T. Tri, M. Janssen, J. Lerut, J.-B. Otte, E. Sokal, J. De Ville de Goyet and R. Reding

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01626.x

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      In this single center pediatric liver transplant series, multivariate analysis showed similar patient and graft survivals with living-related or deceased donors, together with a higher rate of hepatic artery thrombosis and a lower rate of acute rejection in the latter group.

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      Histological Benefit of Retreatment by Pegylated Interferon Alfa-2b and Ribavirin in Patients with Recurrent Hepatitis C Virus Infection Posttransplantation (pages 448–453)

      T. Bizollon, P. Pradat, J.-Y. Mabrut, S. Radenne, C. Ducerf, J. Baulieux, J. C. Souquet and C. Trepo

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01619.x

      Comparison of 27 treated patients to 21 untreated patients demonstrated that retreatment by pegylated inferferon Alfa-2b and ribavirin in patients with recurrent hepatitis C virus infection posttransplant achieved a sustained virologic response in 30% of patients who had failed prior treatment, and that fibrosis scores were improved even when HCV irradication failed.

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      Ten-Year Experience in Porto-Caval Hemitransposition for Liver Transplantation in the Presence of Portal Vein Thrombosis (pages 454–460)

      G. Selvaggi, D. Weppler, S. Nishida, J. Moon, D. Levi, T. Kato and A. G. Tzakis

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01649.x

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      In 23 patients undergoing liver transplantation, using porto-caval hemitransposition, survival was 38% at three years indicating that this is a possible option in patients with complex thrombosis of the mesenteric and portal circulation.

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      The Outcome of Heart Transplant Recipients Following the Development of End-Stage Renal Disease: Analysis of the Canadian Organ Replacement Register (CORR) (pages 461–465)

      A. Alam, K. Badovinac, F. Ivis, L. Trpeski and M. Cantarovich

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01640.x

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      In 2709 heart transplants recorded in the Canadian Organ Replacement Register between 1981 and 2002, those developing end-stage renal disease showed significantly worse mortality on dialysis than a similar dialysis cohort, or than heart transplant patients not developing end-stage renal disease.

  5. Brief Communications

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      Mouse Strain and Injection Site are Crucial for Detecting Linked Suppression in Transplant Recipients by Trans-Vivo DTH Assay (pages 466–470)

      W.J. Burlingham and E. Jankowska-Gan

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01627.x

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      The use of a mouse adoptive host to model human DTH responses is limited by the features of the challenge site and by host immunocompetence.

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      Recovery of Functional Memory T Cells in Lung Transplant Recipients Following Induction Therapy with Alemtuzumab (pages 471–475)

      A. Zeevi, S. Husain, K. J. Spichty, K. Raza, J. B. Woodcock, D. Zaldonis, L. M. Carruth, R. J. Kowalski, J. A. Britz and K. R. McCurry

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01641.x

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      Alemtuzumab T cell depletion in lung transplant patients spares a functional subset of CMV-specific memory T cells, but in CMV-negative recipients depletion may require prolonged prophylaxis.

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      Switching from Tacrolimus to Sirolimus Halts the Appearance of New Sebaceous Neoplasms in Muir-Torre Syndrome (pages 476–479)

      Z. Levi, R. Hazazi, I. Kedar-Barnes, E. Hodak, E. Gal, E. Mor, Y. Niv and J. Winkler

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01648.x

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      This kidney transplant recipient with unrecognized Muir-Torre syndrome developed multiple sebeaceious tumors on tacrolimus that disappeared when the patient was switched to sirolimus, but reappeared when the patient was switched back to tacrolimus.

  6. Case Reports

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. You have free access to this content
      Errors in ABO Labeling of Deceased Donor Kidneys: Case Reports and Approach to Ensuring Patient Safety (pages 480–483)

      A.L. Friedman, K.C. Lee and G.D. Lee

      Article first published online: 6 DEC 2006 | DOI: 10.1111/j.1600-6143.2006.01630.x

      Three cases of mislabelled ABO types of deceased donor kidney containers were recognized through a pre-transplant verification process, and steps to ensure safety are outlined.

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      Acute Sensory Neuropathy Associated with Rabbit Antithymocyte Globulin (pages 484–486)

      M. S. Cartwright, P. S. Moore, P. D. Donofrio, S. S. Iskandar and R. J. Stratta

      Article first published online: 4 JAN 2007 | DOI: 10.1111/j.1600-6143.2006.01637.x

      This patient developed a painful sensory neuropathy within an hour of receiving rabbit anti-thymocyte globulin for treatment of acute renal transplant rejection.

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