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American Journal of Transplantation

Cover image for Vol. 7 Issue 6

June 2007

Volume 7, Issue 6

Pages 1435–1682

  1. Editorials

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      Glucose Metabolic Disorder After Transplantation (pages 1435–1436)

      J. P. Van Hooff, M. H. L. Christiaans and E. M. Van Duijnhoven

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01832.x

      Better evidence on the relative merits of various immunosuppressive regimens for reducing diabetes while preserving overall outcomes is needed. See also article by Vincenti et al in this issue on page 1506.

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      Is It Risky to Use Kidneys from CDC-Increased Risk Donors? (pages 1437–1438)

      A. M. Caliendo and J. R. Lake

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01833.x

      Donors with reported behaviors that increase risk of HIV or HCV may still be suitable for organ transplantation using new nucleic acid testing methods to detect these viruses, leading to more organs utilized at very little additional risk. See also article by Schweitzer et al in this issue on page 1515.

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      Countries' Donation Performance in Perspective: Time for More Accurate Comparative Methodologies (pages 1439–1441)

      L. Roels, B. Cohen* and C. Gachet

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01831.x

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      Using donors per million of population to compare countries for the efficiency of their deceased donation systems may be less informative than a new methodology based on age-standardized deaths per millions. See also article by Cuende et al in this issue on page 1526.

  2. Minireviews

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      Intercellular Transfer of MHC and Immunological Molecules: Molecular Mechanisms and Biological Significance (pages 1442–1449)

      L. A. Smyth, B. Afzali, J. Tsang, G. Lombardi and R. I. Lechler

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01816.x

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      The ability of cells to exchange immunologically important molecules has major implications for understanding immune mechanisms.

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      Options for Immunologic Support of Renal Transplantation Through the HLA and Immunology Laboratories (pages 1450–1456)

      C. Süsal and G. Opelz

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01824.x

      Recent progress in laboratory methods makes it possible for the HLA and immunologic laboratories to provide better guidance to the clinician for case management.

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      CD4+CD25+ Regulatory T Cells in Transplantation: Progress, Challenges and Prospects (pages 1457–1463)

      S. M. Kang, Q. Tang and J. A Bluestone

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01829.x

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      While the relevance of regulatory T cells in clinical transplantation remains unclear, the possible application of such cells remains promising, particularly as a form of immune therapy.

  3. Meeting Report

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      American Society of Transplantation Symposium on B Cells in Transplantation: Harnessing Humoral Immunity from Rodent Models to Clinical Practice (pages 1464–1470)

      A. D. Kirk, W. M. Baldwin, M. I. Cascalho, A. S. Chong, M. Sykes and L. J. West

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01815.x

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      A recent meeting reviewed a number of aspects of antibody and B cell biology in transplantation.

  4. Original Articles:

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. Basic Science

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      Antigenic Disparity Impacts Outcome of Agonism but Not Blockade of Costimulatory Pathways in Experimental Transplant Models (pages 1471–1481)

      M. L. Ford, M. E. Wagener, S. Gangappa, T. C. Pearson and C. P. Larsen

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01826.x

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      While agonistic anti-CD28 and rapamycin synergize to promote protection from GVHD in fully disparate strain combinations, this effect was not observed in minor mismatch models of GVHD, indicating that reduced antigen disparity can actually decrease the efficacy of anti-CD28/rapamycin treatment in this model.

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      Mechanism of NKT Cell-Mediated Transplant Tolerance (pages 1482–1490)

      X. Jiang, S. Kojo, M. Harada, N. Ohkohchi, M. Taniguchi and K.-i. Seino

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01827.x

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      The mechanism of Vα 14 NKT cell-mediated transplant tolerance was elucidated, shedding light on a relation with dendritic cells and CD4 T cells.

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      Induction of Anoikis Following Myoblast Transplantation into SCID Mouse Muscles Requires the Bit1 and FADD Pathways (pages 1491–1505)

      M. Bouchentouf, B. F. Benabdallah, J. Rousseau, L. M. Schwartz and J. P. Tremblay

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01830.x

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      Anoikis, a form of apoptotic cell death caused by cell detachment, limits myoblast transplantation, and is mediated by blockade of the FADD and Bit1 pathways, offering potential for improved transplant efficiency.

    4. Clinical Science

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      Results of an International, Randomized Trial Comparing Glucose Metabolism Disorders and Outcome with Cyclosporine Versus Tacrolimus (pages 1506–1514)

      F. Vincenti, S. Friman, E. Scheuermann, L. Rostaing, T. Jenssen, J. M. Campistol, K. Uchida, M. D. Pescovitz, P. Marchetti, M. Tuncer, F. Citterio, A. Wiecek, S. Chadban, M. El-Shahawy, K. Budde, N. Goto and on behalf of the DIRECT (Diabetes Incidence after Renal Transplantation: Neoral® C2 Monitoring Versus Tacrolimus) Investigators

      Version of Record online: 12 MAR 2007 | DOI: 10.1111/j.1600-6143.2007.01749.x

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      In this 6-month, open-label, randomized, multicenter study in de novo renal transplant patients, the primary safety endpoint of new-onset diabetes after transplant or impaired fasting glucose was significantly less frequent with cyclosporine microemulsion than tacrolimus, with no significant differences in short-term outcome. See also editorial by Van Hooff in this issue on page 1435.

      Corrected by:

      Erratum

      Vol. 8, Issue 4, 908, Version of Record online: 19 FEB 2008

  5. Original Articles

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. Clinical Science

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      Estimated Benefits of Transplantation of Kidneys from Donors at Increased Risk for HIV or Hepatitis C Infection (pages 1515–1525)

      E. J. Schweitzer, E. N. Perencevich, B. Philosophe and S. T. Bartlett

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01769.x

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      A decision analytic Markov model of renal failure treatment modalities found that transplantation of kidneys from donors with behaviors which place them at risk for HIV or hepatitis C infection was beneficial from both the societal and individual patient perspective. See also editorial by Calliendo and Lake in this issue on page 1437.

  6. Original Articles:

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. Clinical Science

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      Effect of Population Aging on the International Organ Donation Rates and the Effectiveness of the Donation Process (pages 1526–1535)

      N. Cuende, J. I. Cuende, J. Fajardo, J. Huet and M. Alonso

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01792.x

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      Because age accounts for 33% of the difference in the donation rates among 43 countries, adjusting donation rates for age should be mandatory before making comparisons. Additionally, effectiveness of donation decreases with older donors. See also editorial by Roels and Cohen in this issue on page 1439.

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      Risk Factors for Urinary Complications After Renal Transplantation (pages 1536–1541)

      M. J. Englesbe, D. A. Dubay, B. W. Gillespie, A. S. Moyer, S. J. Pelletier, R. S. Sung, J. C. Magee, J. D. Punch, D. A. Campbell Jr and R. M. Merion

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01790.x

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      Urinary complications were observed in 6.2% of recipients in this study, and were more frequent in males, African-Americans, and with the use of a “U”-stitch technique. Ureteric strictures increased the rate of graft loss.

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      Insurability of Living Organ Donors: A Systematic Review (pages 1542–1551)

      R. C. Yang, H. Thiessen-Philbrook, S. Klarenbach, S. Vlaicu, A. X. Garg and for the Donor Nephrectomy Outcomes Research (DONOR) Network

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01793.x

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      A systematic review of 2,067 living organ donors, 385 potential donors, and 239 responses from the insurance industry revealed that some living organ donors have difficulties obtaining or maintaining coverage despite insurance companies reporting otherwise.

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      Tubular Basement Membrane Immune Deposits in Association with BK Polyomavirus Nephropathy (pages 1552–1560)

      E. Bracamonte, N. Leca, K. D. Smith, R. F. Nicosia, V. Nickeleit, E. Kendrick, P. S. Furmanczyk, C. L. Davis, C. E. Alpers and J. Kowalewska

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01794.x

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      Tubular basement membrane immune deposits can be seen in a significant proportion of patients with BK polyomavirus nephropathy.

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      Patient and Graft Survival Implications of Simultaneous Pancreas Kidney Transplantation From Old Donors (pages 1561–1571)

      P. R. Salvalaggio, M. A. Schnitzler, K. C. Abbott, D. C. Brennan, W. Irish, S. K. Takemoto, D. Axelrod, L. S. Santos, B. Kocak, L. Willoughby and K. L. Lentine

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01818.x

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      This retrospective study of UNOS data suggests that older simultaneous pancreas kidney transplant donors offer reasonable organ-specific graft survivals and an important patient survival benefit compared to long-term waiting, arguing for consideration of older donors in candidates with decreased access to standard transplants.

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      Early Withdrawal of Calcineurin Inhibitors and Rescue Immunosuppression with Sirolimus-Based Therapy in Renal Transplant Recipients with Moderate to Severe Renal Dysfunction (pages 1572–1583)

      R. K. Wali, V. Mohanlal, E. Ramos, S. Blahut, C. Drachenberg, J. Papadimitriou, M. Dinits, A. Joshi, B. Philosophe, C. Foster, C. Cangro, J. Nogueira, M. Cooper, S. T. Bartlett and M. R. Weir

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01825.x

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      Switch from tacrolimus to sirolimus-based therapy in 136 patients with kidney graft dysfunction was associated with stabilization of GFR, and 13 experienced a first rejection episode.

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      Brain Death Activates Donor Organs and Is Associated with a Worse I/R Injury After Liver Transplantation (pages 1584–1593)

      S. Weiss, K. Kotsch, M. Francuski, A. Reutzel-Selke, L Mantouvalou, R. Klemz, O. Kuecuek, S. Jonas, C. Wesslau, F. Ulrich, A. Pascher, H-D. Volk, S. G. Tullius, P. Neuhaus and J. Pratschke

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01799.x

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      Brain death is associated with a significant upregulation of inflammatory cytokines in the liver and leads to a worse ischemia/reperfusion injury after transplantation.

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      Short Waitlist Time Does Not Adversely Impact Outcome Following Liver Transplantation for Hepatocellular Carcinoma (pages 1594–1600)

      S. D. Chao, J. P. Roberts, M. Farr and F. Y. Yao

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01800.x

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      Patients with HCC who were transplanted within 3 months on the waiting list had no increased risk of tumor recurrence compared to those with longer waiting time, as long as patients met restrictive criteria for liver transplantation.

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      Hepatocellular Carcinoma Recurrence and Death Following Living and Deceased Donor Liver Transplantation (pages 1601–1608)

      R. A. Fisher, L. M. Kulik, C. E. Freise, A. S. F. Lok, T. H. Shearon, R. S. Brown Jr, R. M. Ghobrial, J. H. Fair, K. M. Olthoff, I. Kam, C. L. Berg and and the A2ALL Study Group

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01802.x

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      Of 106 transplant candidates with cirrhosis and HCC who had a potential living donor evaluated, LDLT recipients had lower relative mortality risk than patients who did not undergo LDLT; but LDLT to supplement DDLT in HCC treatment had a cost of higher HCC recurrence in LDLT patients.

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      Once-Daily Tacrolimus Extended-Release Formulation: 1-Year Post-Conversion in Stable Pediatric Liver Transplant Recipients (pages 1609–1615)

      T. G. Heffron, M. D. Pescovitz, S. Florman, M. Kalayoglu, S. Emre, G. Smallwood, K. Wisemandle, C. Anania, S. Dhadda, T. Sawamoto, J. Keirns, W. Fitzsimmons and M. R. First

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01803.x

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      Pediatric liver transplant recipients on twice-daily tacrolimus can be safely converted to and maintained on once daily tacrolimus (Prograf) XL.

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      Tacrolimus Monotherapy Without Steroids After Liver Transplantation – A Prospective Randomized Double-Blinded Placebo-Controlled Trial (pages 1616–1623)

      C. Moench, A.P. Barreiros, M. Schuchmann, F. Bittinger, J. Thiesen, G. Hommel, I. Kraemer and G. Otto

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01804.x

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      This trial comparing tacrolimus monotherapy versus tacrolimus and steroids after orthotopic liver transplantation showed major metabolic benefits in the steroid free group with comparable rejection rates and survival.

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      Changes in International Normalized Ratio (INR) and Model for Endstage Liver Disease (MELD) Based on Selection of Clinical Laboratory (pages 1624–1628)

      J. F. Trotter, J. Olson, J. Lefkowitz, A. D. Smith, R. Arjal and J. Kenison

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01822.x

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      Variations in INR measurements among clinical laboratories may have a substantial effect on MELD scores independent of severity of illness.

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      Whole-Liver Graft Without the Retrohepatic Inferior Vena Cava for Sequential (Domino) Living Donor Liver Transplantation (pages 1629–1632)

      Y. Inomata, M. E. Zeledón, K. Asonuma, H. Okajima, T. Takeichi, T. Ishiko and Y. Ando

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01828.x

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      Domino liver transplantation using a whole familial amyloid polyneuropathy (FAP) liver from a LDLT for a FAP patient presents satisfactory results, even though the transplant procedure is technically complicated.

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      Usefulness of PCR Strategies For Early Diagnosis of Chagas' Disease Reactivation and Treatment Follow-Up in Heart Transplantation (pages 1633–1640)

      M. Diez, L. Favaloro, A. Bertolotti, J. M. Burgos, C. Vigliano, M. P. Lastra, M. J. Levin, A. Arnedo, C. Nagel, A. G. Schijman and R. R. Favaloro

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01820.x

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      PCR strategies to detect minicircle sequences and miniexon genes in parasites proved to be of value for early diagnosis of Chagas 'disease reactivation as well as monitoring treatment efficacy in patients at risk for Chagas 'disease reactivation post heart transplantation.

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      Human Ehrlichiosis in Transplant Recipients (pages 1641–1647)

      L. D. Thomas, I. Hongo, K. C. Bloch, Y.-W. Tang and S. Dummer

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01821.x

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      Ehrlichiosis, a tick-borne illness, occurred in 15 transplant recipients, manifesting different symptoms from those in non-immunosuppressed patients, but still responding to doxycycline therapy, with overall favorable outcomes.

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      Preemptive Therapy of EBV-Related Lymphoproliferative Disease after Pediatric Haploidentical Stem Cell Transplantation (pages 1648–1655)

      P. Comoli, S. Basso, M. Zecca, D. Pagliara, F. Baldanti, M. E. Bernardo, W. Barberi, A. Moretta, M. Labirio, M. Paulli, M. Furione, R. Maccario and F. Locatelli

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01823.x

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      Three patients who progressed to overt PTLD responded to donor EBV-specific cytotoxic T cell infusion and remain in remission.

  7. Brief Communications

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      Financial Implications of Pancreas Transplant Complications: A Business Case for Quality Improvement (pages 1656–1660)

      J. A. Cohn, M. J. Englesbe, Y. M. Ads, J. L. Paruch, S. J. Pelletier, T. H. Welling, C. J. Sonnenday, J. C. Magee, J. D. Punch, D. A. Campbell Jr and R. S. Sung

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01791.x

      Payers should have a significant financial interest in efforts to improve the surgical outcomes of pancreas transplantation.

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      High Expression of Tim-3 mRNA in Urinary Cells from Kidney Transplant Recipients with Acute Rejection (pages 1661–1665)

      P. G. Renesto, V. C. Ponciano, M. A. Cenedeze, N. O. Saraiva Câmara and A. Pacheco-Silva

      Version of Record online: 8 APR 2007 | DOI: 10.1111/j.1600-6143.2007.01795.x

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      Urinary TIM-3 levels assessed by RT-PCR were higher in patients with acute rejection compared to those with other causes of renal dysfunction and stable recipients.

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      BK Virus Associated Renal Cell Carcinoma: Case Presentation with Optimized PCR and Other Diagnostic Tests (pages 1666–1671)

      M. Narayanan, J. Szymanski, E. Slavcheva, A. Rao, A. Kelly, K. Jones and G. Jaffers

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01817.x

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      This carcinoma arising in a renal allograft manifested BK DNA in the primary tumor and in the metastases.

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      A Mouse Model of Orthotopic Vascularized Aerated Lung Transplantation (pages 1672–1679)

      M. Okazaki, A. S. Krupnick, C. G. Kornfeld, J. M. Lai, J. H. Ritter, S. B. Richardson, H. J. Huang, N. A. Das, G. A. Patterson, A. E. Gelman and D. Kreisel

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01819.x

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      This novel model of orthotopic vascularized lung transplantation in the mouse will allow for mechanistic investigations of non-immunological and immunological lung graft injury.

  8. Book Review

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      Atlas of Organ Transplantation by A. Humar, A. J. Matas, W. D. Payne (page 1680)

      N. Kneteman and C. Toso

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01801.x

  9. Erratum

    1. Top of page
    2. Editorials
    3. Minireviews
    4. Meeting Report
    5. Original Articles:
    6. Original Articles
    7. Original Articles:
    8. Brief Communications
    9. Book Review
    10. Erratum
    1. You have free access to this content
      Erratum (page 1681)

      S. Gangappa, C. Larsen and T. Pearson

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2006.01776.x

      This article corrects:

      Alloimmunity: No Toll Exemption

      Vol. 7, Issue 1, 3–4, Version of Record online: 14 DEC 2006

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      Erratum (page 1682)

      Version of Record online: 15 MAY 2007 | DOI: 10.1111/j.1600-6143.2007.01841.x

      This article corrects:

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