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American Journal of Transplantation

Cover image for Vol. 8 Issue 10

October 2008

Volume 8, Issue 10

Pages 1967–2176

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
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  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
    1. You have free access to this content
      AJT's Response to the National Institutes of Health Public Access Regulations (page 1969)

      A. D. Kirk and D. R. Salomon

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02363.x

      The AJT's editorial board endorses a new policy for the Journal to automatically submit papers at the time of acceptance to PubMed to help insure author compliance with the new NIH regulations on public access to NIH-funded research.

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      ‘Tie Breaker’ for HLA Matching in Pediatric Renal Transplant Recipients? (pages 1970–1971)

      P. F. Hoyer

      Article first published online: 8 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02379.x

      It is a time for an open debate on the relative importance of HLA matching versus shorter waiting times and younger donors for pediatric renal transplant recipients. See also article by Gritsch et al in this issue on page 2056.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
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      What's Next in the Pipeline (pages 1972–1981)

      F. Vincenti and A. D. Kirk

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02403.x

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      The current decade has not witnessed the approval of a new immunosuppression drug for transplantation. However the pipeline of new immunosuppressive drugs is being replenished with small molecules targeting novel pathways and new biologics for chronic use, and promises to address previously neglected areas in transplant therapeutics.

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      Liver Transplantation for Hepatocellular Carcinoma: Beyond the Milan Criteria (pages 1982–1989)

      F. Y. Yao

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02351.x

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      This article reviews liver transplantation for hepatocellular carcinoma using expanded criteria, and addresses the challenges of expanding criteria on a broader scale beyond single center experience.

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      The Clinical Impact of Islet Transplantation (pages 1990–1997)

      P. Fiorina, A. M. J. Shapiro, C. Ricordi and A. Secchi

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02353.x

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      The authors review islet transplant outcomes and immunosuppression, and in particular the impact on patient survival and diabetic complications, as well as alternative options.

  4. Special Feature

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
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      Alexis Carrel: Genius, Innovator and Ideologist (pages 1998–2003)

      P. Dutkowski, O. De Rougemont and P.-A. Clavien

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02364.x

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      The versatile scientific achievements of Alexis Carrel make him more than a Nobel prize winning vascular surgeon - this is the story of a father of solid organ transplantation.

  5. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
    1. Basic Science

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      Superagonistic CD28 Antibody Induces Donor-Specific Tolerance in Rat Renal Allografts (pages 2004–2014)

      H. Azuma, Y. Isaka, X. Li, T. Hünig, T. Sakamoto, H. Nohmi, Y. Takabatake, M. Mizui, Y. Kitazawa, N. Ichimaru, N. Ibuki, T. Ubai, T. Inamoto, Y. Katsuoka and S. Takahara

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02358.x

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      A superagonistic monoclonal antibody specific for CD28 (CD28SA) expanded FoxP3+ Treg cells in vivo, and induced donor specific tolerance in rat acute renal allograft model (Wistar to Lewis).

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      Hydrogen Inhalation Ameliorates Oxidative Stress in Transplantation Induced Intestinal Graft Injury (pages 2015–2024)

      B. M. Buchholz, D. J. Kaczorowski, R. Sugimoto, R. Yang, Y. Wang, T. R. Billiar, K. R. McCurry, A. J. Bauer and A. Nakao

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02359.x

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      This study demonstrates that perioperative hydrogen inhalation protects intestinal graft structure and function, and blunts graft and systemic molecular inflammatory responses via its antioxidant effects.

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      Murine Mobilized Peripheral Blood Stem Cells Have a Lower Capacity than Bone Marrow to Induce Mixed Chimerism and Tolerance (pages 2025–2036)

      Z. Koporc, N. Pilat, P. Nierlich, P. Blaha, S. Bigenzahn, I. Pree, E. Selzer, M. Sykes, F. Muehlbacher and T. Wekerle

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02371.x

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      In a murine mixed chimerism model, T cells contained in high numbers in the donor peripheral blood stem cells triggered rejection of the transplanted donor cells.

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      Transplant Acceptance Following Anti-CD4 Versus Anti-CD40L Therapy: Evidence for Differential Maintenance of Graft-Reactive T Cells (pages 2037–2048)

      S. C. Wood, G. Lu, B. E. Burrell and D. K. Bishop

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02372.x

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      Using an adoptive transfer system, this study revealed that anti-CD4 and anti-CD40L therapies result in distinct profiles of cytokine production and abilities to mediate rejection by graft-reactive T cells.

  6. Brief Communication:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
    1. Basic Science

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      Donor Fas Is Not Necessary for T-Cell-Mediated Rejection of Mouse Kidney Allografts (pages 2049–2055)

      D. Kayser, G. Einecke, K. S. Famulski, M. Mengel, B. Sis, L.-F. Zhu and P. F. Halloran

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02375.x

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      In mouse kidney allografts, donor Fas was not necessary for histologic lesions such as tubulitis or epithelial deterioration, even in the absence of host perforin-granzyme mechanisms, suggesting that neither Fas-Fas ligand nor perforin-granzyme cytotoxic mechanisms are necessary for T cell-mediated rejection.

  7. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
    1. Clinical Science

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      Should Pediatric Patients Wait for HLA-DR-Matched Renal Transplants? (pages 2056–2061)

      H. A. Gritsch, J. L. Veale, A. B. Leichtman, M. K. Guidinger, J. C. Magee, R. A. McDonald, W. E. Harmon, F. L. Delmonico, R. B. Ettenger and J. M. Cecka

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02320.x

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      The current 5-year graft survival benefit of DR matching in pediatric renal transplantation is not statistically significant suggesting that children should not wait for long periods on dialysis to achieve DR matched kidneys. See also editorial by Hoyer in this issue on page 1970.

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      Substantial Variation in the Acceptance of Medically Complex Live Kidney Donors Across US Renal Transplant Centers (pages 2062–2070)

      P. P. Reese, H. I. Feldman, M. A. McBride, K. Anderson, D. A. Asch and R. D. Bloom

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02361.x

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      A retrospective study using UNOS data demonstrated that 24% of live kidney donors had obesity, hypertension, or low estimated glomerular filtration rate at the time of donor nephrectomy.

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      Earlier Is Not Necessarily Better in Preemptive Kidney Transplantation (pages 2071–2076)

      S. K. Akkina, J. J. Connaire, J. J. Snyder, A. J. Matas and B. L. Kasiske

      Article first published online: 8 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02381.x

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      In this single-center study of 671 kidney transplants, pre-emptive kidney transplantation with higher eGFR did not improve graft survival compared to pre-emptive transplantation with lower eGFR.

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      Nephrectomy Elicits Impact of Age and BMI on Renal Hemodynamics: Lower Postdonation Reserve Capacity in Older or Overweight Kidney Donors (pages 2077–2085)

      M. Rook, R. J. Bosma, W. J. Van Son, H. S. Hofker, J. J. Homan Van Der Heide, P. M. Ter Wee, R. J. Ploeg and G. J. Navis

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02355.x

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      This study shows that after living kidney donation, renal reserve capacity - obtained as the rise in GFR on dopamine infusion - was lower in older or overweight donors and even absent in obese donors.

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      The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation (pages 2086–2096)

      J. A. Bluestone, W. Liu, J. M. Yabu, Z. G. Laszik, A. Putnam, M. Belingheri, D. M. Gross, R. M. Townsend and F. Vincenti

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02377.x

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      Anti-CD25 (daclizumab) but not LEA29Y (Belatacept) or calcineurin inhibitor therapy causes a transient reduction in CD25+ Foxp3+ regulatory T cells in kidney transplant recipients.

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      Portal Vein Complications in Pediatric Living Donor Liver Transplantation Using Left-Side Grafts (pages 2097–2105)

      M. Ueda, F. Oike, M. Kasahara, Y. Ogura, K. Ogawa, H. Haga, Y. Takada, H. Egawa, K. Tanaka and S. Uemoto

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02360.x

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      In 521 pediatric living donor liver transplants using left-side grafts, portal vein occlusion was as a critical complication leading to graft losses, if not corrected interventionally or surgically, especially for children weighing less than 6 kg.

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      Anesthesia-Related Complications in Living Liver Donors: The Experience from One Center and the Reporting of One Death (pages 2106–2110)

      S. Ozkardesler, D. Ozzeybek, E. Alaygut, T. Unek, M. Akan, H. Astarcioglu, S. Karademir, I. Astarcioglu and Z. Elar

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02367.x

      This study of anesthetic complications and outcomes for 113 living liver donors found one death from pulmonary embolism and a number of major morbidities including central venous catheter-induced thrombosis, nerve damage, and postdural puncture headache.

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      Prevention of Posttransplant Cytomegalovirus Disease and Related Outcomes with Valganciclovir: A Systematic Review (pages 2111–2118)

      H-Y. Sun, M. M. Wagener and N. Singh

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02369.x

      Late-onset CMV disease in solid organ transplant recipients is observed uniquely with the use of valganciclovir as prophylaxis, but not as preemptive therapy.

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      Screening of Organ and Tissue Donors for West Nile Virus by Nucleic Acid Amplification – A Three Year Experience in Alberta (pages 2119–2125)

      Peter A. G. Tilley, Julie D. Fox, Bonita Lee, Linda Chui and Jutta Preiksaitis

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02365.x

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      Screening of organ and tissue donors in this study was implemented without compromising availability of organs and tissues, but required committed laboratory suppor.

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      Alemtuzumab Induction and Steroid-Free Maintenance Immunosuppression in Pancreas Transplantation (pages 2126–2131)

      A. S. R. Muthusamy, A. C. Vaidya, S. Sinha, D. Roy, D. E. Elker and P. J. Friend

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02373.x

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      This single centre analysis of 100 consecutive pancreas transplants suggests that alemtuzumab induction allows safe and effective steroid-free maintenance immunosuppression.

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      Association between Primary Graft Dysfunction among Lung, Kidney and Heart Recipients from the Same Multiorgan Donor (pages 2132–2139)

      T. Oto, L. Excell, A. P. Griffiths, B. J. Levvey, M. Bailey, S. Marasco, P. Macdonald and G. I. Snell

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02357.x

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      In 202 multi-organ donors, there was an association between early graft dysfunction in 231 pulmonary, 378 renal and 114 cardiac transplant recipients, suggesting potent unknown donor factors exert an important affect on transplant outcomes.

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      Impact of Human Donor Lung Gene Expression Profiles on Survival after Lung Transplantation: A Case-Control Study (pages 2140–2148)

      M. Anraku, M. J. Cameron, T. K. Waddell, M. Liu, T. Arenovich, M. Sato, M. Cypel, A. F. Pierre, M. De Perrot, D. J. Kelvin and S. Keshavjee

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02354.x

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      Human donor lungs have distinctive pre-implantation gene expression signatures that are associated with post transplant primary graft dysfunction.

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      Female-Versus-Male Alloreactivity as a Model for Minor Histocompatibility Antigens in Hematopoietic Stem Cell Transplantation (pages 2149–2157)

      M. Stern, R. Brand, T. De Witte, A. Sureda, V. Rocha, J. Passweg, H. Baldomero, D. Niederwieser and A. Gratwohl

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02374.x

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      This study of over 50,000 allogeneic hematopoietic stem cell transplants found that female donor to male recipient transplants showed more chronic graft versus host disease and late mortality but lower disease relapse rates.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Special Feature
    6. Original Articles:
    7. Brief Communication:
    8. Original Articles:
    9. Case Reports
    1. You have free access to this content
      Sequential Pancreaticoduodenectomy after Living Donor Liver Transplantation for Cholagiocacinoma (pages 2158–2162)

      Y. Soejima, S. Ueda, K. Sanefuji, H. Kayashima, T. Yoshizumi, T. Ikegami, Y. Yamashita, K. Sugimachi, T. Iguchi, A. Taketomi and Y. Maehara

      Article first published online: 22 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02346.x

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      Planned pancreaticoduodenectomy was performed sequentially 44 days after successful living donor liver transplantation, providing a safe and feasible option to treat cholangiocarcinoma complicating primary sclerosing cholangitis.

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      Successful Three-Way Kidney Paired Donation with Cross-Country Live Donor Allograft Transport (pages 2163–2168)

      R. A. Montgomery, S. Katznelson, W. I. Bry, A. A. Zachary, J. Houp, J. M. Hiller, S. Shridharani, D. John, A. L. Singer and D. L. Segev

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02347.x

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      Transporting a kidney in a triple kidney paired donation enabled a highly sensitized patient to receive a well-matched kidney from a live donor on the opposite coast, with immediate function and a 1-year serum creatinine of 1.1 mg/dl.

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      Some Issues in Facial Transplantation (pages 2169–2172)

      Y. Chenggang, H. Yan, Z. Xudong, L. Binglun, Z. Hui, M. Xianjie, Y. Li, F. Xing, L. Yunjing, L. Kaihua, L. Huiyuan, Z. Yan, Z. Guoyou and G. Shuzhong

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02352.x

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      This report examines surgical indications, techniques, risk versus benefit, informed consent, and psychosocial, societal and financial issues of human facial transplantation.

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      Severe Renal Vein Stenosis of a Kidney Transplant with Beneficial Clinical Course after Successful Percutaneous Stenting (pages 2173–2176)

      A. Obed, D. C. Uihlein, N. Zorger, S. Farkas, M. N. Scherer, B. Krüger, B. Banas and B. K. Krämer

      Article first published online: 16 SEP 2008 | DOI: 10.1111/j.1600-6143.2008.02356.x

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      Marked functional deterioration of this kidney transplant was reversed by percutaneous stent angioplasty, with marked improvement in kidney function and long-term survival.

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