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American Journal of Transplantation

Cover image for Vol. 8 Issue 2

February 2008

Volume 8, Issue 2

Pages 263–476

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
    1. You have free access to this content
  2. Editorial

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
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      Trials and Tribulations of Steroid Withdrawal After Kidney Transplantation (pages 265–266)

      H.-U. Meier-Kriesche, J. C. Magee and B. Kaplan

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02084.x

      In the current enthusiasm for steroid avoidance, the potential risks of rejection and worse renal function must not be ignored. See also article by Vincenti et al in this issue on page 307.

  3. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
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      Qualification of Biomarkers for Drug Development in Organ Transplantation (pages 267–270)

      Gilbert J. Burckart, Shashi Amur, Federico M. Goodsaid, Lawrence J. Lesko, Felix W. Frueh, Shiew-Mei Huang and Marc W. Cavaille-Coll

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02063.x

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      FDA-qualified biomarkers are badly needed for drug development in transplantation, and multiple mechanisms exist for transplant clinicians and researchers to contribute to the qualification process.

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      Reducing Bile Leak Following Segmental Liver Transplantation: Understanding Biliary Anatomy of the Caudate Lobe (pages 271–274)

      W. Jassem, N. D. Heaton and M. Rela

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02069.x

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      Many cut surface bile leaks arise from biliary radicals that drain the caudate lobe, and may be avoided by a better understanding of the anatomy of the caudate lobe and its drainage.

  4. Special Feature

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
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      Primum Non Nocere (pages 275–276)

      G. B. Klintmalm

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02055.x

      It is time for the transplant community to develop a consensus on when the risk to the living donor is justified and when it is not, in relationship to the potential benefits to the recipient.

  5. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
    1. Basic Science

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      The Role of Angiogenic and Wound Repair Factors During CMV-Accelerated Transplant Vascular Sclerosis in Rat Cardiac Transplants (pages 277–287)

      D. N. Streblow, C. N. Kreklywich, T. Andoh, A.V. Moses, J. Dumortier, P. P. Smith, V. Defilippis, K. Fruh, J. A. Nelson and S. L. Orloff

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02062.x

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      Analysis of rat heart allografts from RCMV-infected recipients demonstrated that RCMV up-regulates genes involved in wound healing and angiogenesis, and dysregulation of these genes was highest during the time period of TVS acceleration.

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      In Vitro and in Vivo Prevention of Human CD8+ CTL-Mediated Xenocytotoxicity by Pig c-FLIP Expression in Porcine Endothelial Cells (pages 288–297)

      M. Tanemura, A. Saga, K. Kawamoto, T. Deguchi, T. Machida, T. Nishida, Y. Sawa and T. Ito

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02077.x

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      Overexpression of FLICE inhibitory protein (c-FLIPS/L), an inhibitor of death receptor-mediated apoptotic signals prevents the cytotoxicity of human CD8+−CTLs against pig endothelial cells.

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      Ex Vivo-Expanded Natural CD4+CD25+ Regulatory T Cells Synergize With Host T-Cell Depletion to Promote Long-Term Survival of Allografts (pages 298–306)

      G. Xia, J. He and J. R. Leventhal

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02088.x

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      Alloantigen-enriched, transforming growth factor-β/interleukin-2-conditioned natural Foxp3+CD4+CD25+ regulatory T cells synergize with peri-transplant host T-cell depletion to induce long-term survival of heart allografts in wild-type mice

    4. Clinical Science

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      A Randomized, Multicenter Study of Steroid Avoidance, Early Steroid Withdrawal or Standard Steroid Therapy in Kidney Transplant Recipients (pages 307–316)

      F. Vincenti, F. P. Schena, S. Paraskevas, I. A. Hauser, R. G. Walker, J. Grinyo and on behalf of the FREEDOM Study Group

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02057.x

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      In the multicenter FREEDOM study of 336 de novo renal transplant patients randomized to no steroids, steroids to Day 7 or standard steroids, early steroid withdrawal resulted in similar one-year renal function to the standard steroids regimen, and appeared preferable to complete steroid avoidance. See also editorial by Meier-Kriesche et al in this issue on page 265.

      Corrected by:

      Erratum

      Vol. 8, Issue 5, 1080, Version of Record online: 14 APR 2008

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      The Utility of 1- and 3-Month Protocol Biopsies on Renal Allograft Function: A Randomized Controlled Study (pages 317–323)

      J. Kurtkoti, V. Sakhuja, K. Sud, M. Minz, R. Nada, H. S. Kohli, K. L. Gupta, K. Joshi and V. Jha

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02049.x

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      This prospective randomized study carried out in 102 living-related renal transplant recipients show that early protocol biopsies detect subclinical histological changes in the graft, and the biopsied group had lower 6-month and 1-year serum creatinine values.

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      Clinical Relevance of Preformed HLA Donor-Specific Antibodies in Kidney Transplantation (pages 324–331)

      C. Lefaucheur, C. Suberbielle-Boissel, G. S. Hill, D. Nochy, J. Andrade, C. Antoine, C. Gautreau, D. Charron and D. Glotz

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02072.x

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      The presence of preformed HLA donor specific antibodies is strongly associated with graft loss in kidney transplants, related to an increased risk of antibody-mediated rejection.

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      Influenza Vaccination Is Efficacious and Safe in Renal Transplant Recipients (pages 332–337)

      J. Scharpé, P. Evenepoel, B. Maes, B. Bammens, K. Claes, A. D. Osterhaus, Y. Vanrenterghem and W. E. Peetermans

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02066.x

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      Influenza vaccination in 165 renal transplant recipients resulted in seroprotection rates and seroresponse rates similar to those obtained in controls, without affecting allograft function. Seroresponse rates were lower with MMF usage and with low baseline seroprotection.

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      Homeostatic Repopulation by CD28CD8+ T Cells in Alemtuzumab-Depleted Kidney Transplant Recipients Treated With Reduced Immunosuppression (pages 338–347)

      P. Trzonkowski, M. Zilvetti, S. Chapman, J. Więckiewicz, A. Sutherland, P. Friend and K. J. Wood

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02078.x

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      In 13 kidney allograft recipients treated with alemtuzumab followed by reduced doses of MMF and tacrolimus, the recovery of CD8+ T cells was much faster than that of CD4+ T cells, and the repopulating CD8+ T cells were mainly of the immunosenescent CD28-CD8+ phenotype.

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      Results of Positive Cross-Match Transplantation in African American Renal Transplant Recipients (pages 348–354)

      P. West-Thielke, H. Herren, J. Thielke, J. Oberholzer, H. Sankary, V. Raofi, E. Benedetti and B. Kaplan

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02085.x

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      This study demonstrates worrisome trends in outcomes of desensitized African American renal transplant recipients, with more rejection and poorer renal function than crossmatch negative recipients.

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      HIV-Infected Liver and Kidney Transplant Recipients: 1- and 3-Year Outcomes (pages 355–365)

      M. E. Roland, B. Barin, L. Carlson, L. A. Frassetto, N. A. Terrault, R. Hirose, C. E. Freise, L. Z. Benet, N. L. Ascher, J. P. Roberts, B. Murphy, M. J. Keller, K. M. Olthoff, E. A. Blumberg, K. L. Brayman, S. T. Bartlett, C. E. Davis, J. M. McCune, B. M. Bredt, D. M. Stablein and P. G. Stock

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02061.x

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      Good transplant and HIV-related outcomes among HIV-infected kidney recipients, and reasonable outcomes among liver transplant recipients, suggest that transplantation is an option for selected HIV-infected patients cared for at centers with adequate expertise.

      Corrected by:

      Erratum

      Vol. 8, Issue 5, 1081, Version of Record online: 14 APR 2008

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      Ascites in Hepatitis C Liver Transplant Recipients Frequently Occurs in the Absence of Advanced Fibrosis (pages 366–376)

      B. Y. Lan, G. M. Landry, V. O. Tan, A. Bostrom and S. Feng

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02046.x

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      In HCV positive liver transplant recipients, 2/3 of ascites episodes occur without significant fibrosis or liver pathology.

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      Heme Oxygenase-1 Genotype of the Donor Is Associated With Graft Survival After Liver Transplantation (pages 377–385)

      C. I. Buis, G. van der Steege, D. S. Visser, I. M. Nolte, B. G. Hepkema, M. Nijsten, M. J. H. Slooff and R. J. Porte

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02048.x

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      Some polymorphisms affecting the promoter of heme oxygenase-1 were associated in this study with differences in graft survival and primary dysfunction.

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      Liver Retransplantation in Children: A SPLIT Database Analysis of Outcome and Predictive Factors for Survival (pages 386–395)

      V. Ng, R. Anand, K. Martz and A. Fecteau

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02056.x

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      In 246 children who have underwent a second liver transplant, survival was decreased compared to primary liver transplants, especially for those who required early retransplantation.

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      Risk Factors for Rejection and Infection in Pediatric Liver Transplantation (pages 396–403)

      R. W. Shepherd, Y. Turmelle, M. Nadler, J. A. Lowell, M. R. Narkewicz, S. V. McDiarmid, R. Anand, C. Song and the SPLIT Research Group

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02068.x

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      In this systematic concurrent analysis of rates and risks of rejection and infection in 2291 pediatric liver transplants, infection risk far exceeded that of rejection, which caused limited harm to the patient or graft, particularly in infants.

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      Improving Outcomes of Liver Retransplantation: An Analysis of Trends and the Impact of Hepatitis C Infection (pages 404–411)

      M. Ghabril, R. Dickson and R. Wiesner

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02082.x

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      An analysis of the UNOS database for patients undergoing liver transplantation between 1994 and 2005 revealed improved outcomes for retransplantation over recent years for both HCV and Non-HCV patients.

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      Waiting Before Birth: Outcomes After Fetal Listing for Heart Transplantation (pages 412–418)

      S. M. Pollock-BarZiv, B. W. McCrindle, L. J. West and A. I. Dipchand

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02047.x

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      Of 26 fetuses wait-listed for heart transplants in Toronto, 18 underwent heart transplants at 4 hours to 2.6 months after delivery.

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      The Survival Benefit of Deceased Donor Liver Transplantation as a Function of Candidate Disease Severity and Donor Quality (pages 419–425)

      D. E. Schaubel, C. S. Sima, N. P. Goodrich, S. Feng and R. M. Merion

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02086.x

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      Transplanting livers with a high donor risk index into candidates with lower MELD scores fails to maximize survival benefit and may deny lifesaving organs to high MELD candidates who are at high risk of death without transplantation.

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      Antifungal Management Practices in Liver Transplant Recipients (pages 426–431)

      N. Singh, M. M. Wagener, T. V. Cacciarelli and J. Levitsky

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02089.x

      A vast majority of the liver transplant centers in North America employ antifungal prophylaxis and most use targeted prophylaxis.

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      Donors After Cardiac Death: Validation of Identification Criteria (DVIC) Study for Predictors of Rapid Death (pages 432–441)

      M. A. DeVita, M. Mori Brooks, C. Zawistowski, S. Rudich, B. Daly and E. Chaitin

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02087.x

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      The UNOS criteria to identify potential organ donors after cardiac death were validated in this large multicenter observational study of patients who had life sustaining treatments removed in the intensive care unit.

  6. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
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      Chronic High Epstein-Barr Viral Load State and Risk for Late-Onset Posttransplant Lymphoproliferative Disease/Lymphoma in Children (pages 442–445)

      M. A. Bingler, B. Feingold, S. A. Miller, E. Quivers, M. G. Michaels, M. Green, R. M. Wadowsky, D. T. Rowe and S. A. Webber

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02080.x

      Pediatric heart transplant patients who carry very high Epstein-Barr Virus loads in their peripheral blood over prolonged periods have a high rate of development of late onset PTLD, often with aggressive histology.

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      Left Ventricular Mass Is Associated With Ventricular Repolarization Heterogeneity One Year After Renal Transplantation (pages 446–451)

      M. Arnol, V. Starc, B. Knap, N. Potočnik, A. F. Bren and A. Kandus

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02083.x

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      In a study of 68 renal transplant recipients, greater left ventricular mass was associated with increased ventricular repolarization heterogeneity assessed by the beat-to-beat QT interval variability algorithm, providing a link with the high risk of arrhythmia and cardiac death in this population.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
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      Hepatocyte Transplantation Followed by Auxiliary Liver Transplantation—a Novel Treatment for Ornithine Transcarbamylase Deficiency (pages 452–457)

      J. Puppi, N. Tan, R. R. Mitry, R. D. Hughes, S. Lehec, G. Mieli-Vergani, J. Karani, M. P. Champion, N. Heaton, R. Mohamed and A. Dhawan

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02058.x

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      This child with antenatally diagnosed severe ornithine transcarbamylase deficiency was successfully bridged to auxiliary partial orthotopic liver transplantation by hepatocyte transplantation.

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      Intramuscular Autotransplantation of Pancreatic Islets in a 7-Year-Old Child: A 2-Year Follow-Up (pages 458–462)

      E. Rafael, A. Tibell, M. Rydén, T. Lundgren, L. Sävendahl, B. Borgström, U. Arnelo, B. Isaksson, B. Nilsson, O. Korsgren and J. Permert

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02060.x

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      This child received received autologous islet transplantation to an extrahepatic site after total pancreatecomy with evidence of long-term function.

  8. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
    1. You have free access to this content
      Kidney Paired Donation With Compatible Pairs (page 463)

      A. E. Roth, T. Sönmez and M. U. Ünver

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02052.x

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      Working Together Toward a National Kidney Paired Donation Program (page 464)

      S. E. Gentry, D. L. Segev and R. A. Montgomery

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02070.x

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      Sticky Platelet Syndrome: A Manageable Risk Factor for Posttransplant Thromboembolic Events (page 465)

      J-M. El-Amm, J. Andersen and S. A. Gruber

      Version of Record online: 18 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02059.x

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      Do We Know Enough to Mandate Donor Evaluation Testing? (page 466)

      Martha Pavlakis, Douglas Hanto and Didier Mandelbrot

      Version of Record online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02067.x

  9. Errata

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
    1. You have free access to this content
      Erratum (page 467)

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02073.x

      This article corrects:
  10. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal Viewpoints
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    11. Erratum
    1. You have free access to this content
      Erratum (page 468)

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02074.x

      This article corrects:

      Orthotopic Ileal Neobladder Reconstruction after Renal Transplant

      Vol. 7, Issue 11, 2630–2633, Version of Record online: 9 OCT 2007

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      Erratum (pages 469–470)

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02075.x

      This article corrects:
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      Erratum (page 471)

      Version of Record online: 15 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02076.x

      This article corrects:
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      Erratum (pages 472–476)

      Version of Record online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02090.x

      This article corrects:

      Sirolimus-Associated Infertility: Case Report and Literature Review of Possible Mechanisms

      Vol. 7, Issue 10, 2414–2421, Version of Record online: 31 AUG 2007

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