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American Journal of Transplantation

Cover image for Vol. 8 Issue 3

March 2008

Volume 8, Issue 3

Pages 477–730

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Organ Preservation—Can We Do It Better? (pages 479–480)

      R. Shapiro and P. F. Halloran

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02132.x

      Organ preservation is an important area in organ transplantation, and probably deserves more priority in research than it receives. See also article by Lynch et al in this issue on page 567.

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      Cold Ischemia Time and Liver Graft Survival (pages 481–482)

      J. C. Hong and R. W. Busuttil

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02149.x

      Early liver graft failure remains a serious concern, in which prolonged cold ischemia time interacts with numerous factors. See also article by Segev et al in this issue on page 658.

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      Long-Term Follow-Up and Large Patient Cohorts: A Substitute for Randomized Controlled Trials? (pages 483–484)

      J. J. Curtis

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02148.x

      The issues such as corticosteroid avoidance or minimization can ultimately only be resolved with randomized control trials. See also article by Anil Kumar in this issue on page 574.

  3. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Is DCD for Liver Transplantation DNR? (pages 485–488)

      J. F. Renz

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02111.x

      We need to improve our understanding of the pathophysiology of donation after cardiac death and develop new predictors of successful donation.

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      Ischemic Preconditioning: Promises from the Laboratory to Patients—Sustained or Disillusioned? (pages 489–491)

      M. L. DeOliveira, R. Graf and P.-A. Clavien

      Article first published online: 7 JAN 2008 | DOI: 10.1111/j.1600-6143.2007.02091.x

      While recent experience with ischemic preconditioning in liver transplantation is not encouraging, it would be premature to conclude that it has no role for improving results in liver transplantation.

  4. Minireview

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Transplant Glomerulopathy (pages 492–496)

      F. G. Cosio, J. M. Gloor, S. Sethi and M. D. Stegall

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02104.x

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      Transplant glomerulopathy is a unique and important disease entity in kidney allografts that is currently the subject of increasing attention as attempts are made to develop interventions that arrest its progression.

  5. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
    1. Basic Science

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      ICOS-Dependent and -Independent Functions of Memory CD4 T Cells in Allograft Rejection (pages 497–506)

      Q.-W. Zhang, M. Rabant, A. Schenk and A. Valujskikh

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02096.x

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      In mouse cardiac allografts, blockade of the costimulatory ICOS pathway inhibited recruitment of activated memory and effector T cells to the graft and in combination with other interventions prevented help by memory CD4 T cells in antibody production.

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      Enhanced Allograft Survival and Modulation of T-Cell Alloreactivity Induced by Inhibition of MMP/ADAM Enzymatic Activity (pages 507–516)

      V. L. Eaton, N. M. Lerret, M. M. Velásquez-Lopera, R. John, M. Caicedo, R. P. DeCresce and A. Jaramillo

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02097.x

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      In mouse heart transplants, inhibitors of MMPs and ADAMs enhanced allograft survival and lowered cellular infiltration suggesting they may represent novel therapeutic targets.

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      Allograft Airway Fibrosis in the Pulmonary Milieu: A Disorder of Tissue Remodeling (pages 517–528)

      M. Sato, M. Liu, M. Anraku, T. Ogura, G. D'Cruz, B. A. Alman, T. K. Waddell, E. Kim, L. Zhang and S. Keshavjee

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02106.x

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      In a tracheal transplant model of obliterative bronchiolitis in rats, MMP inhibition reduced airway deterioration without inhibiting T cell activation.

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      Correlation of Motility and Neuronal Integrity with a Focus on the Grade of Intestinal Allograft Rejection (pages 529–536)

      T. Watanabe, K. Hoshino, M. Tanabe, S. Kawachi, G. Wakabayashi, M. Shimazu, Y. Morikawa and M. Kitajima

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02115.x

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      Intestinal allograft dysmotility, such as absence of migrating motor complex and high prevalence of discrete clustered contraction or non-propagating contraction, could be a useful marker of progression of acute rejection and help guide treatment decisions.

      Corrected by:

      Erratum

      Vol. 8, Issue 6, 1355, Article first published online: 29 APR 2008

      Corrected by:

      Erratum

      Vol. 8, Issue 6, 1356, Article first published online: 29 APR 2008

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      Silencing S1P1 Receptors Regulates Collagen-V Reactive Lymphocyte-Mediated Immunobiology in the Transplanted Lung (pages 537–546)

      M. Chiyo, T. Iwata, T. J. Webb, M. R. Vasko, E. L. Thompson, K. M. Heidler, O. W. Cummings, S. Yoshida, T. Fujisawa, D. D. Brand and D. S. Wilkes

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02116.x

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      Sphingosine-1-phosphate receptors may have novel roles including modulation of lymphocyte activation in addition to their roles in lymphocyte emigration.

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      Interferon-γ and Donor MHC Class I Control Alternative Macrophage Activation and Activin Expression in Rejecting Kidney Allografts: A Shift in the Th1-Th2 Paradigm (pages 547–556)

      K. S. Famulski, B. Sis, L. Billesberger and P. F. Halloran

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02118.x

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      Interferon-γ may control the phenotype of allograft rejection in part by inducing donor class I, which in turn engages inhibitory receptors to signal the host cells.

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      Acute Humoral Rejection of Renal Allografts in CCR5–/– Recipients (pages 557–566)

      A. Bickerstaff, T. Nozaki, J.-J. Wang, R. Pelletier, G. Hadley, G. Nadasdy, T. Nadasdy and R. L. Fairchild

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02125.x

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      Kidney allografts lacking chemokine receptor CCR5 manifest accelerated rejection with many of the histologic features observed In antibody-mediated rejection in human allografts.

    8. Clinical Science

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      Comparison of Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Preservation in Renal Transplantation (pages 567–573)

      R. J. Lynch, J. Kubus, R. H. Chenault, S. J. Pelletier, D. A. Campbell and M. J. Englesbe

      Article first published online: 19 DEC 2007 | DOI: 10.1111/j.1600-6143.2007.02065.x

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      Histidine-tryptophan-ketoglutarate preservation fluid reduces the risk of delayed graft function in kidney allografts, as shown in this retrospective analysis of outcomes after kidney transplantation, compared to UW solution. See also editorial by Shapiro and Halloran in this issue on page 479.

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      Long-Term Outcome of Early Steroid Withdrawal After Kidney Transplantation in African American Recipients Monitored by Surveillance Biopsy (pages 574–585)

      M. S. Anil Kumar, S. Khan, K. Ranganna, G. Malat, N. Sustento-Reodica and W. C. Meyers

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02099.x

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      Early steroid withdrawal in African American recipients is associated with an increase in sub-clinical inflammation and lower renal function. See also editorial by Curtis in this issue on page 483.

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      The Effects of Donor and Recipient Practices on Transplant Center Finances (pages 586–592)

      M. J. Englesbe, Y. Ads, J. A. Cohn, C. J. Sonnenday, R. Lynch, R. S. Sung, S. J. Pelletier, J. D. Birkmeyer and J. D. Punch

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02098.x

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      The use of high risk kidney donors is associated with transplant center financial losses.

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      Patient Survival and Cardiovascular Risk After Kidney Transplantation: The Challenge of Diabetes (pages 593–599)

      F. G. Cosio, L. J. Hickson, M. D. Griffin, M. D. Stegall and Y. Kudva

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02101.x

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      Survival after kidney transplantation is significantly different with patients having pre-existing diabetes mellitus and those with new onset diabetes mellitus, with the former having an excess of cardiovascular disease relative to the latter.

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      Monocyte Infiltration and Kidney Allograft Dysfunction During Acute Rejection (pages 600–607)

      R. Girlanda, D. E. Kleiner, Z. Duan, E. A. S. Ford, E. C. Wright, R. B. Mannon and A. D. Kirk

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02109.x

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      In analyzing the characteristics associated with functionally significant human acute renal allograft rejection, the authors find that monocyte content and renal tubular HLA-DR expression are strongly related to the clinical dysfunction associated with a rejection episode.

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      Beta-Trace Protein-Based Equations for Calculation of GFR in Renal Transplant Recipients (pages 608–615)

      U. Pöge, T. Gerhardt, B. Stoffel-Wagner, H. Palmedo, H.-U. Klehr, T. Sauerbruch and R. P. Woitas

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02117.x

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      A serum beta-trace protein-based formula for glomerular filtration rate is described that estimates true GFR virtually without bias, and may serve as an alternative to calculations such as the MDRD equation.

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      Diagnostic Accuracy of Measurement Methods to Assess Non-Adherence to Immunosuppressive Drugs in Kidney Transplant Recipients (pages 616–626)

      P. Schäfer-Keller, J. Steiger, A. Bock, K. Denhaerynck and S. De Geest

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02127.x

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      In this cross-sectional comparison of methods of assessing adherence to immunosuppressive therapy regimens, no measures showed high sensitivity and specificity, indicating that combined measures may be required.

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      The Transcriptome of Human Cytotoxic T Cells: Similarities and Disparities Among Allostimulated CD4+ CTL, CD8+ CTL and NK cells (pages 627–636)

      L. G. Hidalgo, G. Einecke, K. Allanach and P. F. Halloran

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02128.x

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      Comparison of the transcriptome of CD4+ CTL, CD8+ CTL and NK cells found extensive similarity between CD4+ and CD8+ CTL, with no transcripts in CD4+ CTL distinguishing them from CD8+ CTL, although a number of NK-associated transcripts distinguished NK cells from CTL.

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      The Transcriptome of Human Cytotoxic T Cells: Measuring the Burden of CTL-Associated Transcripts in Human Kidney Transplants (pages 637–646)

      L. G. Hidalgo, G. Einecke, K. Allanach, M. Mengel, B. Sis, T. F. Mueller and P. F. Halloran

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02129.x

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      In human renal transplant biopsies, a set of 25 highly expressed cytotoxic T lymphocyte-associated transcripts quantitatively measured the burden of effector T cells and effector memory T cells in the allografts, varying between 3-15% of the signal intensity of a pure cytotoxic T cell culture and correlating with the degree of infiltration.

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      The Geography of Kidney Transplantation in the United States (pages 647–657)

      B. L. Kasiske, J. J. Snyder, M. A. Skeans, A. V. Tuomari, J. R. Maclean and A. K. Israni

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02130.x

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      Variation in the distance between kidney transplant recipients' homes and their transplant centers is assessed along with the likelihood of traveling to a center that is not closest to home.

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      Effect Modification in Liver Allografts With Prolonged Cold Ischemic Time (pages 658–666)

      D. L. Segev, L. M. Kucirka, G. C. Nguyen, A. M. Cameron, J. E. Locke, C. E. Simpkins, P. J. Thuluvath, R. A. Montgomery and W. R. Maley

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02108.x

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      In this analysis of UNOS data, the authors identified recipient and donor characteristics which significantly amplified the adverse effects of prolonged cold ischemic time on liver allograft survival. See also editorial by Busutill in this issue on page 481.

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      The Impact of Obesity on Long-term Outcomes in Liver Transplant Recipients—Results of the NIDDK Liver Transplant Database (pages 667–672)

      J. Leonard, J. K. Heimbach, M. Malinchoc, K. Watt and M. Charlton

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02100.x

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      Corrected BMI is not independently predictive of patient or graft outcomes in this analysis of the NIDDK liver transplantation database, indicating that obesity should not be considered a contraindication to liver transplantation.

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      Correlation Between Liver Fibrosis and Inflammation in Patients Transplanted for HCV Liver Disease (pages 673–678)

      L. Baiocchi, M. Angelico, A. Petrolati, L. Perrone, G. Palmieri, S. Battista, M. Carbone, L. Tariciotti, C. Longhi, G. Orlando and G. Tisone

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02107.x

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      In HCV liver transplanted patients histological staging is strictly correlated with grading; however the increase in fibrosis progression observed in HCV patients, transplanted in more recent age, is not fully explained by a more intense liver inflammation.

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      Clinical Benefits of Antiviral Therapy in Patients with Recurrent Hepatitis C Following Liver Transplantation (pages 679–687)

      M. Berenguer, A. Palau, V. Aguilera, J.-M. Rayón, F. S. Juan and M. Prieto

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02126.x

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      This study of antiviral therapy in liver transplant recipients treated with interferon or pegylated interferon plus ribavirin compared to untreated controls, demonstrated that antiviral therapy was associated with improved long-term outcomes in recurrent HCV.

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      Atypical Acute Rejection After Hand Transplantation (pages 688–696)

      S. Schneeberger, V. S. Gorantla, R. P. Van Riet, M. Lanzetta, P. Vereecken, C. Van Holder, S. Rorive, M. Remmelink, A. Le Moine, D. Abramowicz, B. Zelger, C. L. Kaufman, W. C. Breidenbach, R. Margreiter and F. Schuind

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02105.x

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      In four cases, hand transplants presented with an atypical pattern of rejection involving the palmar skin and the nails, which persisted over weeks to months and responded poorly to steroid treatment but did respond to antithymocyte globulin.

  6. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Outcome of Renal Transplantation in Eight Patients with Candida sp. Contamination of Preservation Fluid (pages 697–700)

      M. Matignon, F. Botterel, V. Audard, B. Dunogue, K. Dahan, P. Lang, S. Bretagne and P. Grimbert

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02112.x

      In eight patients with Candida contamination of the preservation fluid, none developed arterial aneurysms and all had good outcomes, suggesting that this complication may often be benign, although six patients required treatment with antifungal drugs.

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      Clinical Magnetic Resonance Imaging of Pancreatic Islet Grafts After Iron Nanoparticle Labeling (pages 701–706)

      C. Toso, J.-P. Vallee, P. Morel, F. Ris, S. Demuylder-Mischler, M. Lepetit-Coiffe, N. Marangon, F. Saudek, A. M. James Shapiro, D. Bosco and T. Berney

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02120.x

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      Post-transplant monitoring of iron labeled-islet graft is feasible in clinical practice.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Human Herpesvirus-8 (HHV-8)-Associated Primary Effusion Lymphoma in two Renal Transplant Recipients Receiving Rapamycin (pages 707–710)

      E. Boulanger, P. V. Afonso, Y. Yahiaoui, H. Adle-Biassette, J. Gabarre and F. Agbalika

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02110.x

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      Two HIV-uninfected HHV-8-infected males of African origin who underwent renal transplantation and developed PEL while receiving rapamycin-based immunosuppression.

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      A ‘Dangerous’ Group O Donor: Severe Hemolysis in All Recipients of Organs from a Donor with Multiple Red Cell Alloantibodies (pages 711–714)

      J. Shortt, G. P. Westall, D. Roxby, J. W. Chen, G. I. Snell, M. N. Polizzotto, G. Magrin, A. Webb, A. M. Street, M. Borosak, E. M. Wood and M. F. Cole-Sinclair

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02113.x

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      Clinically significant hemolysis due to passenger lymphocyte syndrome in all recipients of organs from a donor with a rare blood type and multiple red cell antibodies.

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      Thoracoscopic-Assisted Placement of Azygos Vein Central Venous Catheter in a Child (pages 715–718)

      J. E. Sola and W. R. Thompson

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02121.x

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      This case illustrates the use of thoracoscopic-assisted central access in a child requiring chronic hemodialysis with limited venous sites due to thrombosis of central vessels.

  8. Special Feature: Obituary

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      H. Myron Kaufman (1933–2007) Medical Director and Senior Scientist of UNOS: Transplant Surgeon and Friend (pages 719–720)

      J. F. Buell, P. Daily, M. A. McBride, J. R. Chapman and F. Delmonico

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02102.x

  9. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
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      Waiting Time and Use of Living Donors (page 721)

      D. H. Howard

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02079.x

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      Response to ‘Waiting Time and Use of Living Donors’ (page 722)

      Dorry L. Segev, Sommer E. Gentry and Robert A. Montgomery

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02095.x

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      Successful Liver Transplantation from a 95-Year-Old Donor to a Patient with MELD Score 36 and Delayed Graft Arterialization (pages 725–726)

      Gian Luca Grazi, Matteo Cescon, Matteo Ravaioli, Barbara Corti and Antonio Daniele Pinna

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02114.x

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  10. Reviewers List 2007

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Minireview
    6. Original Articles:
    7. Brief Communications
    8. Case Reports
    9. Special Feature: Obituary
    10. Letters to the Editor
    11. Reviewers List 2007
    1. You have free access to this content
      Reviewers List 2007 (pages 727–730)

      Article first published online: 19 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02187.x

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